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Longitudinal cortex-wide overseeing associated with cerebral hemodynamics as well as air metabolic rate inside alert rats making use of multi-parametric photoacoustic microscopy.
In conclusion, conducting the exercise program in the afternoon might be more effective for improving cognitive functions and the mood of older adults than in the morning. However, there was heterogeneity between the groups despite the randomization. Therefore, we suggest conducting a more rigorously controlled study using a larger sample to validate these findings.The article analyzes the results of the impact of an integrated approach to lifestyle modification, including Nordic walking, rational nutrition and pharmacotherapy, on the quality of life of elderly people (average age 72,5±3,6 years). A significant improvement in the pain scale indicator of the MOS SF-36 was revealed after six months (p=0,001), which was also determined by the end of the year (p=0,0001). A tendency to improve the quality of life was revealed in the Minnesota Questionnaire after six months (p=0,0617). A significant improvement in the Minnesota Quality of Life Questionnaire was found after a year of applying this approach (p=0,0001). The relationship of improving quality of life indicators and a significant decrease in systolic blood pressure (p=0,0016) and diastolic blood pressure (p=0,0032) in elderly people after a one-year practice of an original approach to lifestyle modification is discussed.An anonymous random survey of 186 diabetic patients over 65 years of age with Type 2 diabetes (105 women, 81 men) from Stara Zagora, Bulgaria, was randomly conducted. The opin-ion of the diabetic patients has been studied about the need of help (health and social) to improve their quality of life with diabetes; their desire to be consulted by a health care professional in a home environment; the topics they would like to be consulted; their awareness of the complica-tions of untreated diabetes; the degree of awareness of the symptoms of hypoglycaemia and hy-perglycaemia; their rediness to be included in training to acquire knowledge of a life with diabe-tes and preferred learning themes. It turns out that elderly with diabetes report having a need for health care and social support to improve the quality of their life. More than half of the surveyed respondents (52%) over the age of 65 who were diagnosed with diabetes need health and social assistance and nursing home patronage to improve their quality of life. A high percentage (60%) of those surveyed also need information with regard to the treatment; 50% with regard to nutri-tion, 39% with regard to exercise and 50% with regard to the complications from diabetes.Flourishing is of great importance in all age groups, but it becomes even more important in the aging period. The aim of this study was the evaluation of the psychometric properties of the Persian version of PERMA-Profiler for using it as a flourishing assessment tool in Iranian older adults. This cross-sectional study implemented in 3 phases. In phase 1 - the questionnaire was translated into Persian using the forward-backward translation method; in phase 2 - quantitative and qualitative face validity, content validity, and content validity index were evaluated; in phase3 - confirmatory and exploratory factor analysis, concurrent validity, convergent and divergent validity, and reliability were evaluated. The reliability of the instrument was assessed by Cronbach's alpha coefficient, split-half coefficient, and stability by the test-retest method. Smallest detectable change and Standard error of measurement were calculated, too. Persian version of the PERMA-Profiler with 14 items had a good correlation coefficient between with Geriatric Depression Scale and CASP-19 (0/545 GDS and 0,303 CASP-19). In exploratory factor analysis, three factors were extracted and explained 52% of the variance of the PERMA-Profiler score. DLin-KC2-DMA Confirmatory factor analysis confirmed the existence of three factors. The instrument showed good stability, repeatedly and reliability (p less then 0,0001, α=0,896, Spearman correlation coefficient =0,745 and ICC=0,693). The standard error size was small and acceptable. The Persian version of the PERMA-Profiler is an appropriate tool to measure the flourishing among the Iranian elderly and to identify successful older individuals.Merkels cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a high rate of recurrence and local metastasis. The average age at which MCC is diagnosed is 75 years. The identification of the role of somatic mutations and DNA repair in aging mechanisms raises the question of their direct connection with the processes of differentiation, age-related characteristics of the immune system, programmed cell death and malignant growth. In this regard, there remains a need for research aimed at improving the early diagnosis and pathogenetic treatment of elderly patients.Malignant tumors of the eye and its adnexa (C69) are rare malignancies. To date state statistics in Russia (Form No. 7) have data only for estimating the incidence of the population. These data, at our proposal, were included in Form No. 7 only since 2011. In 2018 for the first time we were able to have data on the incidence of the population by age separately for men and women but only in Russia as a whole. The estimation of rates of a 1- and 5-year patient survival for this pathology is carried out only by us in the North-West Federal Region of Russia, where, in February 2019, we have formed the first Population-based Cancer Registry (PCR) in Russia at the Federal Region's level with a total database of more than 1 million cases. Previously similar work was conducted on the materials of the Population-based Cancer Registry of Saint-Petersburg. For the first time this work presents the features of data on changes in the structure of oncological pathology of the eye and its adnexa (C69) and estimations of a 5-year survival by age. Unfortunately the Office of the Federal State Statistics Service classifies the pathology of the eye (C69) as a group of «other malignant tumors» and does not publish mortality data. At the same time, using the PCR database, it must be borne in mind that index accuracy (the ratio of a number of deaths to a number of sick for the first time in life) according to malignant tumors of the eye (C69) is about 0,50% and is constantly decreasing.
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