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Examination regarding Earth Contaminants with Most likely Harmful Factors and also Earth Ecotoxicity associated with Organic Back garden in Brno, Czech Republic: Are generally City Organic Home gardens Much more Contaminated As compared to City Theme parks?
Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient time. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoid, and phenolics. These compounds possess pharmacological properties which makes it anti-diabetic, antipyretic, anti-inflammatory, anti-oxidant, hepatoprotective, and immuno-modulatory. However, due to the increasing population, there is an inadequate supply of drugs. Therefore, this review focuses on the phytochemistry, ethnopharmacology, clinical application and its conservation strategies so that the plant can be conserved for future generations and utilized as an alternative medicine as well as to design various pharmacologically important drugs. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] The quality of traditional Chinese medicine (TCM), reflected by its bioactive compounds and associated contents, is directly linked to its clinical efficacy. Therefore, it is of great importance to improve the quality of TCM by increasing the bioactive compound content. METHODS Mapping the active component content-associated QTLs in TCM and further marker-assisted breeding have enabled us to rapidly and effectively cultivate new varieties with high bioactive compound contents, which has opened the door for genetic breeding studies on medicinal plants. RESULTS In this paper, a strategy and technical molecular breeding method for TCM are discussed. The development of, four methods of and progress in functional marker development as well as the applications of such markers in TCM are reviewed. CONCLUSION The progress in, challenges of, and future of marker-assisted breeding for quality improvement of TCM are discussed, which provide valuable scientific references for future molecular breeding. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] In the last decade there have been accumulating data that the use of medicinal plants could bring additional benefits to the supportive treatment of various diseases. Nigella sativa (N. sativa, family Ranunculaceae) is one of these plants that has attracted considerable interest. The extracts and seeds of N. sativa and its active component thymoquinone have been studied extensively and the results suggest that N. sativa might carry some therapeutic potential for many diseases, including cancer. METHODS The selection criteria for references were applied through Pubmed with "N. sativa and cancer", "N. sativa and breast cancer", "N. sativa and metastasis", "N. sativa and cytotoxicity of natural killer cells". The pathway analysis was performed using the PANTHER tool by using five randomly selected N. sativa affected genes (Cyclin D1, P53, p21 protein (Cdc42/Rac) activated kinase 1 (PAK1), B-cell lymphoma 2 (Bcl-2) and vascular endothelial growth factor (VEGF)) in order to elucidate further potentially affected signaling pathways. RESULTS AND CONCLUSION The aim of this review was to summarize studies regarding the effects of N. sativa in cancer generally, with a focus on breast cancer, its anti-metastatic effects, and how N. sativa modulates the cytotoxicity of Natural Killer cells that play a crucial role in tumor surveillance. In summary, the data suggest that N. sativa might be used for its anti-cancer and anti-metastatic properties and as an immune system activator against cancer. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Paraphenylene diamine (PPD) is a highly toxic compound used for hair-dyeing worldwide. PPD self-poisoning had significantly increased in recent times with raised mortality rates. OBJECTIVE This study aims to evaluate the toxic effects of PPD and protective potential of its prospective antidote Virgin Coconut Oil (Cocos Nucifera). METHOD PPD was identified and validated by FT-IR and UV mass spectrometer. PPD toxicity was induced in-vivo by single intra-peritoneal injection (40 mg/kg and 60 mg/kg). Single injection of Virgin Coconut Oil (VCO) was administered in presence of PPD at doses of 5 mg/kg and 10 mg/kg. Blood was analyzed for renal, hepatic and cardiac biomarkers. Relevant organs were collected, weighted and preserved for histopathological examination. Statistical analysis carried to note mortality rate, survival duration and serum biochemical parameter. Molecular docking studies were performed to assess attachment of PPD with histaminergic receptors. RESULTS PPD injection achieved 100% mortality rate with short survival span, and disturbed hepatic, renal, and cardiac serum markers with marked histopathological changes. VCO notably decreased mortality rate, raised treatment time window with marked adjustment in hepatic, renal, and cardiac markers. Docking studies proved that PPD attaches robustly with histaminergic receptors. CONCLUSION Study concludes that VCO possesses lifesaving protection against PPD toxicity and can be a suitable antidote. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Despite improved overall outcomes rejection continues to occur frequently after pancreas transplantation. OBJECTIVE To review the literature and to provide a state-of-the-art assessment of current practice and developments of immunosuppressive regimens in pancreas transplantation. METHODS The English literature was reviewed. Relevant articles were retrieved and analysed. RESULTS Induction therapy is used in approximately 90% of the transplants, with T-cell depleting antibodies being the prevalent therapy (>90%). Despite the initial enthusiasm on steroid-free regimens, maintenance protocols continue to be mostly based on a combination of steroids, tacrolimus, and mycophenolate mofetil. Tacrolimus is used in the majority of recipients. GSK3787 order Sirolimus is rarely used at the time of transplant and is introduced later on in approximately 10% of the recipients, mostly in the context of a switching strategy to address the side effects of calcineurin inhibitors. The overall quality of published studies was quite low, because of the retrospective design, the heterogeneity of study groups with respect to PTx categories, the inclusion of mixed recipient categories with respect to immunologic risk profile, and the use of non-standardized concurrent immunosuppressive therapies.
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