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An esophagectomy is the key component of curative esophageal cancer treatment. Textbook outcome is a composite measure describing an optimal perioperative course, including parameters regarding a radical resection with at least 15 lymph nodes and an uncomplicated postoperative course without hospital readmission. This study assessed clinicopathological predictors for textbook outcome and the association of textbook outcome with survival in two tertiary referral centers.

All esophageal cancer patients who underwent an esophagectomy with gastric tube reconstruction and curative intent between 2007-2016 were included. Patients with a carcinoma in situ and patients undergoing a salvage or non-elective procedure were excluded. Primary endpoint was the association of textbook outcome for esophageal cancer surgery with long-term survival. Secondary endpoints were clinicopathological predictors for textbook outcome.

In total, 1065 patients were included, of whom 327 achieved textbook outcome (30.7%). Squamous cell carcinoma (OR 0.56, 95%CI 0.39-0.80), hybrid approach (OR 0.30, 95%CI 0.10-0.89), and ASA class ≥2 predicted worse textbook outcome-rate (ASA-II OR 0.33, 95%CI 0.22-0.49; ASA-III/IV OR 0.68, 95%CI 0.48-0.96), whereas neo-adjuvant therapy predicted better textbook outcome-rate (OR 1.58, 95%CI 1.08-2.31). Superior overall (HR 0.77, 95%CI 0.64-0.93) and disease-free survival (0.80, 95%CI 0.67-0.96) were observed in the textbook outcome group.

Achieved textbook outcome was associated with better overall and disease-free survival, illustrating the association of improved short-term outcomes and long-term survival and the importance of pursuing textbook outcome.
Achieved textbook outcome was associated with better overall and disease-free survival, illustrating the association of improved short-term outcomes and long-term survival and the importance of pursuing textbook outcome.
Intraoperative molecular imaging (IMI) may improve surgical outcomes during pulmonary resection for lung cancer. A multi-institutional Phase 2 IMI clinical trial was conducted utilizing a near-infrared (NIR), folate-receptor targeted contrast agent for lung adenocarcinomas, OTL38. The primary goal was to determine if OTL38 improved surgeons' ability to identify hard-to-find nodules, occult cancers, and positive margins.

Patients with lung nodules received OTL38 (0.025mg/kg) preoperatively. Patients had IMI sequentially during lung inspection, tumor resection, and margin check. Efficacy was evaluated by occurrence of clinically significant events (CSE), occurrences that caused the surgeon to modify the operation or up-stage the patient's cancer. Safety was assessed for single intravenous dose of OTL38.

Of 110 patients recruited; 92 were eligible for analysis. During Lung Inspection, IMI found 24 additional nodules, 9 (10%) of which were cancers that had not been known preoperatively. During Tumor Resection, IMI located 11 (12%) lesions that the surgeon could not find. During Margin Check, IMI revealed 8 positive margins (9%) that the surgeon thought was negative. Benefits of IMI were pronounced in patients undergoing sublobar pulmonary resections and in those with ground-glass opacities. There were no serious adverse events. All surgeons felt comfortable with the procedures by 10 cases.

In this Phase 2 clinical trial, IMI improved outcomes for 26% of patients. A randomized, multi-institutional Phase 3 clinical trial is underway.
In this Phase 2 clinical trial, IMI improved outcomes for 26% of patients. A randomized, multi-institutional Phase 3 clinical trial is underway.
To report the effectiveness and safety of transcatheter arterial sclerosing embolization (TASE) for the treatment of parotid infantile hemangiomas that did not respond appreciably to propranolol.

A total of 21 infants (12 male and 9 female) with large propranolol-resistant infantile hemangiomas in the parotid region were enrolled in this study. During TASE, the feeding arteries of the lesions were embolized using pingyangmycin-lipiodol emulsion and polyvinyl alcohol particles (300-500 μm) to reduce the blood flow rate. All children were followed up as outpatients at 2 weeks and monthly thereafter. The curative effect was evaluated at the 1- and 3-month follow-up visits.

Nine lesions were located on the right side of the parotid gland, whereas 12 were located on the left side. selleckchem The feeding arteries in all patients originated from branches of the external carotid artery. TASE was technically successful in all patients. The mean (± SD) maximal diameter of the hemangiomas significantly decreased from 6.50 cm ± 2.28 before treatment to 3.56 cm ± 1.84 at 1 month after TASE (P <. 05). Three months after TASE, the mean maximal diameter further significantly decreased to 1.94 cm ± 1.58 (P <. 05). During the follow-up period, 16 cases were rated as excellent and 5 as good; no recurrence or serious complications were noted. Minor side effects, such as slight pain, mild fever, and tissue swelling, were observed.

TASE significantly decreased the size of the parotid hemangiomas with minor side effects during a short follow-up period.
TASE significantly decreased the size of the parotid hemangiomas with minor side effects during a short follow-up period.
The present study aims to develop and validate four simple, sensitive, reproducible, and low-cost spectrophotometric methods for the determination of antimigraine drug (eletriptan hydrobromide) in pure form and pharmaceutical formulations.

The methods are based on the formation of yellow colored ion-pair complex between eletriptan hydrobromide and four acid dyes, namely, bromocresol purple (BCP), bromocresol green (BCG), bromophenol blue (BPB), and bromothymol blue (BTB) with absorption maxima at 410, 420, 414 and 416nm, respectively. Several parameters such as pH, buffer type and volume, reagent volume, sequence of addition and effect of extracting solvent were optimized.

Under the optimum experimental conditions, beer's law is obeyed over the concentration ranges of 1.0-20 and 1.0-16μgmL
for (BCP or BCG) and (BPB or BTB), respectively with good correlation coefficients (0.9995-0.9999). The apparent molar absorptivity and Sandell's sensitivity values are reported for all methods. The limit of detection (LOD) and the limit of quantification (LOQ) values are found to be 0.
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