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A clinicopathological outline involving COVID-19-induced chilblains (COVID-toes) related having a posted novels assessment.
5%) . 168 cases (34.78%) had abnormal pulmonary function. Compared with the relatively harmless group, the proportion of abnormal pulmonary function of workers in mild, moderate and severe hazard groups were higher, FEV1, FVC, FEV1/FVC values were lower, the differences were statistically significant (P less then 0.05) . The rank of coal dust (exhaled dust) was negatively correlated with FEV1, FVC and FEV1/FVC (P less then 0.01) . Conclusion Attention should be paid to the supervision and management of relatively harmless and slightly harmful coal dust posts. FVC may be one of the lung function indexes sensitive to coal dust exposure.Objective To investigate the reliability and validity of Stanford attendance scale (sps-6) in the study of attendance among professional groups. Methods In August, 2018, the 1455 employees from 81 workplaces in Beijing, Shanghai, Jiangsu and Guangdong were randomly investigated as the subjects. Epacadostat mouse The reliability and validity of sps-6 were analyzed by using the internal consistency reliability (Cronbach's coefficient) , half split half coefficient, content validity, integration validity, discrimination validity, cluster analysis and structural validity analysis. Results Cronbach's coefficients of sps-6 scale, working process and work results were 0.692, 0.918 and 0.907, respectively; Guttman of scales and dimensions The split half coefficients were 0.792, 0.803 and 0.794, respectively; Pearson correlation coefficients of the total score of each item and scale were 0.526-0.673 (P less then 0.01) ; the qualification rate of set validity and differentiation validity were 100%; the results of cluster analysis supported the theoretical basis for the formation of the scale. The general non-standard fitting index (TLI) =0.982, approximate error mean square root mean square (RMSEA) =0.071, comparative fit index (CFI) =0.990, fit goodness index (GFI) =0.987, modified fit goodness index (AGFI) =0.965, Norm fit index (NFI) =0.990. The results showed that the scale had higher structural validity, and the results of sps-6 in the occupational population were (21.36±4.04) , and the distribution was normal (deviation was 0.053, peak was 0.023) . The scores of sps-6 scale were statistically different in various charactoristics of gender, age, education level, marital status, annual income, position, position level and industry (P less then 0.01) . Conclusion Stanford attendance scale has high reliability and validity, and can be applied to the study of attendance in professional groups.Objective To investigate the effect of exposure to occupational hazard factors on serum bilirubin in workers. Methods In April 2019, using cluster sampling method 5 433 workers exposed to occupational hazard factors from July 2017 to March 2019 were screened out by questionnaire and laboratory test, the date of serum bilirubin were used by the logistic regression analysis of single factor card test and wilcoxon band symbol rank and test. Results The bilirubin decreases with age, is higher in male than in female, the han is higher than the uygur, and the unmarried workers is higher than the married one, there was significant difference in the levels of bilirubin between different genders, ages, ethnic groups and marriages (P less then 0.01) . There were statistically significant differences in bilirubin among the occupational hazard factors (P less then 0.01) , the bilirubin level is highest in the exposure to physical factors, followed by chemical factors and dust. The multivariate logistic regression analysis showed that the dust was the main factor affecting bilirubin (OR(dusr/TBIL)=2.080, 95%CI 1.542~2.807, P less then 0.01) . Abnormal alanine aminotransferase (ALT) and alanine aminotransferase (AST) are consistent with elevated bilirubin. Conclusion Exposure to occupational hazard factors may lead to elevated serum bilirubin and abnormal liver function transaminase, the prevention and control of occupational hazards and cccupational health monitoring should be strengthened.Objective To investigate the characteristics of pulmonary function changes and its possible influencing factors in patients with pneumoconiosis. Methods In December 2019, pneumoconiosis patients hospitalized in four departments of occupational diseases in Hunan Occupational Disease Prevention and Control Hospital from December 2015 to December 2016 were selected as subjects. Lung function including forced vital capacity (FVC) , FVC%, forced expiratory volume in one second (FEV1) , FEV1%, forced expiratory volume in one second / forced vital capacity (FEV1/FVC) , diffusion capacity of the lung foe carbon monoxide% (DLCO%) 、maximal expiratory rlow 75% (MEF75%) , maximal expiratory rlow 50% (MEF50%) and maximal expiratory rlow 25% (MEF25%) were tested, and collect their age, occupation history, smoking history and Chronic Obstructive Pulmonary Disease Self Rating Questionnaire (CAT) score. They were followed up after 3 years to analyze the 3-year decline rates of lung function indicators and their relationship we changes of CAT scores (r=0.147, 0.208, 0.210, 0.196, P less then 0.05) . Logistic regression analysis showed that old age and high initial value of DLCO% were the risk factor for the decline of DLCO% (OR=1.105、1.078, P less then 0.05) .High smoking index was the risk factors for the decline of MEF75% (OR=1.016, P less then 0.05) . High stage and the increase of CAT score were the risk factors for the decline of MEF50% (OR=1.548, 1.162, P less then 0.05) . High initial value of MEF25% was the risk factor for the decline of MEF25% (OR=1.010, P less then 0.05) . Conclusion The pulmonary function index of pneumoconiosis patients declined significantly in 3 years. The stage of pneumoconiosis, age, smoking index and degree of pulmonary function damage were related to the decline rate of pulmonary function.Objective To study the protective effect and effect of SphK1 overexpression on the injury of nerve cells induced by acrylamide. Methods ACR with 99% purity was prepared into 1.25 mmol/L and 2.5 mmol/L solutions. SH-SY5Y cells were divided into control group (NC group) , experimental group and SphK1 activator group. The experimental group was given ACR solution with final concentration of 1.25 mmol/L and 2.5 mmol/L respectively for 24 h. In the SphK1 activator group, on the basis of the exposure concentration of the experimental group, the SphK1 specific activator (12-) phorbol tetradecanoate (-13-) acetate (PMA) solution[prepared by dimethyl sulfoxide (DMSO) , the final concentration was 100 nmol/l], and other treatments were the same as the experimental group. Control group (NC group) added PMA solution into normal cells. Western blot was used to detect the expression of SphK1 protein; CCK-8 was used to detect the proliferation of SH-SY5Y cells; hoechst33342 method was used to observe the morphological changes of nerve cells; flow cytometry was used to analyze the apoptosis of cells.
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