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4, 0.8, and 1.2 m/s) under two different conditions one with the motors producing no torque to compensate for friction, and the other having the motors injecting power to overcome passive friction based on a feedforward friction model. Average oxygen consumption in the uncompensated condition across all speeds, measured in Metabolic Equivalent of Task (METs), was statistically different than the friction compensated condition. There was an average decrease of 8.8% for METs and 1.9% for heart rate across all speeds. While oxygen consumption was reduced when the brace performed friction compensation, other factors may have a greater contribution to the metabolic energy consumption when using the device. Future studies will assess the effects of gravity compensation on the muscular effort required to lift the weight of the distal segments of the exoskeleton as well as the sagittal plane constraint on walking motions in individuals with spinal cord injuries (SCI).Using soft pneumatic actuator is a feasible solution in the complex unstructured environment, owing to their inherent compliance, light weight, and safety. However, due to the limitations of soft actuators' materials and structures, they fall short of motion accuracy and load capacity, or need large-size, bulky compressors. Meanwhile, in order to gain better control, it is essential for them to sense the environments as well. This leads to high-price sensors or a complicated manufacture technique. Here, a self-sensing vacuum soft actuation structure is proposed, aiming at acquiring good balance among precision, output force, and actuation pressure. The actuator mainly comprises a flexible membrane and a compression spring. When actuated, the flexible membrane outside the actuator compresses the internal spring skeleton, realizing large contractile motion in axial direction. Its built-in force sensor can indirectly measure the absolute displacement of the actuator with certain accuracy (about 5% F.S.). Besides, it does not require high actuation pressure to generate enough output force. The actuator is quite easy to manufacture with low cost, and there are a variety of materials to choose from. We established quasi-static models for actuators built of two different kinds of membrane materials, and tested their accuracy and output force. In addition, to break through the limits of vacuum actuation, a method of positive-negative pressure combined actuation has been proposed, which lowers the requirements for air source equipments, increases actuation pressure, and reduces potential safety threats at the same time. This kind of soft actuators can also effectively resist and detect impacts. The design of a two-finger dexterous robot hand and robot joint based on this soft actuator illustrates its broad application prospects in the fields of mobile robots, wearable devices, and human-robot interaction.Purpose The clinical diagnosis of aorta coarctation (CoA) constitutes a challenge, which is usually tackled by applying the peak systolic pressure gradient (PSPG) method. Recent advances in computational fluid dynamics (CFD) have suggested that multi-detector computed tomography angiography (MDCTA)-based CFD can serve as a non-invasive PSPG measurement. The aim of this study was to validate a new CFD method that does not require any medical examination data other than MDCTA images for the diagnosis of CoA. Materials and methods Our study included 65 pediatric patients (38 with CoA, and 27 without CoA). All patients underwent cardiac catheterization to confirm if they were suffering from CoA or any other congenital heart disease (CHD). A series of boundary conditions were specified and the simulated results were combined to obtain a stenosis pressure-flow curve. Subsequently, we built a prediction model and evaluated its predictive performance by considering the AUC of the ROC by 5-fold cross-validation. Results The proposed MDCTA-based CFD method exhibited a good predictive performance in both the training and test sets (average AUC 0.948 vs. 0.958; average accuracies 0.881 vs. 0.877). It also had a higher predictive accuracy compared with the non-invasive criteria presented in the European Society of Cardiology (ESC) guidelines (average accuracies 0.877 vs. 0.539). Conclusion The new non-invasive CFD-based method presented in this work is a promising approach for the accurate diagnosis of CoA, and will likely benefit clinical decision-making.Recently, deep convolutional neural networks (DCNNs) have attained human-level performances on challenging object recognition tasks owing to their complex internal representation. DMXAA research buy However, it remains unclear how objects are represented in DCNNs with an overwhelming number of features and non-linear operations. In parallel, the same question has been extensively studied in primates' brain, and three types of coding schemes have been found one object is coded by the entire neuronal population (distributed coding), or by one single neuron (local coding), or by a subset of neuronal population (sparse coding). Here we asked whether DCNNs adopted any of these coding schemes to represent objects. Specifically, we used the population sparseness index, which is widely-used in neurophysiological studies on primates' brain, to characterize the degree of sparseness at each layer in representative DCNNs pretrained for object categorization. We found that the sparse coding scheme was adopted at all layers of the DCNNs, and the degree of sparseness increased along the hierarchy. That is, the coding scheme shifted from distributed-like coding at lower layers to local-like coding at higher layers. Further, the degree of sparseness was positively correlated with DCNNs' performance in object categorization, suggesting that the coding scheme was related to behavioral performance. Finally, with the lesion approach, we demonstrated that both external learning experiences and built-in gating operations were necessary to construct such a hierarchical coding scheme. In sum, our study provides direct evidence that DCNNs adopted a hierarchically-evolved sparse coding scheme as the biological brain does, suggesting the possibility of an implementation-independent principle underling object recognition.
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