Notes

Specific Deubiquitinating Enzymes Advertise Web host Constraint Elements In opposition to HIV/SIV Trojans.
lt in the inflation of the positive predictive value, when the true prevalence of the infection remains very low among the tested individuals. Here we try to summarize some of the potentially most relevant diagnostic conclusions of the pandemic so far according to our own data and the literature. Orv Hetil. 2021; 162(52) 2071-2078.Összefoglaló. A veleszületett légúti szűkületek gyakran kombináltan jelentkeznek, és más szervrendszert is érintő kísérőbetegségekkel, illetve malformációkkal is társulhatnak. Figyelembe véve ezeket a tényezőket, illetve a csecsemőkori légút speciális anatómiáját és sérülékeny szöveteit, a felső légúti szűkületek sebészi kezelése újszülött- és csecsemőkorban igen nagy kihívást jelentő feladat, melynek célja a mihamarabbi definitív, stabil légút biztosítása a hangképzés és a nyelési funkció megőrzésével. A laryngomalacia, a hangszalagbénulás és a subglotticus stenosis együttesen a gége veleszületett rendellenességeinek megközelítőleg 90%-áért felelős. A szerzők erre a három kórképre fókuszálva egy-egy eset kapcsán bemutatják a Szegedi Tudományegyetem Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinikáján működő légútsebészeti munkacsoport által rutinszerűen alkalmazott innovatív sebészi módszereket. A bemutatott sebészeti megoldások egy lépésben, tracheostoma, sztentelés és graft beültetése nélkül azonnali stabil lve surgical strategies in connection with three cases. The presented 'one-step' surgical solutions provide immediate stable airway with good voice quality and swallowing function without tracheostomy, stenting, or graft implantation for both dynamic and static stenoses of the supraglottis, glottis, and subglottis. Orv Hetil. 2021; 162(52) 2100-2106.Összefoglaló. A tibiatörés a gyermekkorban előforduló leggyakoribb csontsérülések egyike. Felosztása során elsődlegesen elkülönítendők a növekedési zóna közeli, az azt érintő, illetve a diaphysisre lokalizált sérülések. A gyermekkor jelentette speciális adottságoknak - mint a jó gyógy- és regenerációs hajlam - köszönhetően a tibiatörések kezelése az esetek többségében konzervatív módon kitűnő eredményekkel végezhető. A kezelési lehetőségek fejlődésével, illetve a sérülteknek a mielőbbi funkcionális felépüléshez való megnövekedett igénye miatt az elmúlt időszakban a műtétes beavatkozások aránya egyértelmű emelkedést mutatott. Ez kifejezetten igaz a lábszártestet érintő törésekre. A műtétes beavatkozások során elsődleges szempont a minimális invazivitásra való törekvés, kitüntetett figyelmet fordítva a növekedési zónák iatrogén károsításának elkerülésére. A megfelelő terápiás módszer megválasztása során azonban a sérülés lokalizációja és típusa mellett szem előtt kell tartani a sérült gyermek életkorát, fizikálome in most cases. However, the rate of operative management has risen recently due to the improvement of treatment options and the patients' increasing demand for a quick functional recovery, especially in the treatment of diaphyseal fractures. Pursuing a minimally invasive method is an essential aspect of operative management, while special attention is paid to avoid further iatrogenic damage to the physes. When selecting the adequate method for treatment, the age, physical condition, and personal needs of the injured child should also be considered along with fracture type and localization. This review aims to provide a comprehensive summary about pediatric tibial fractures, especially the available therapeutic approaches. A strong emphasis is placed on the treatment of adolescent diaphyseal fractures, highlighting the recent changes in strategy and the authors' innovation in the operative management of adolescent diaphyseal fractures. Orv Hetil. 2021; 162(52) 2079-2088.Összefoglaló. A terhesség során a szervezet hormonrendszerében jelentős változások mennek végbe, melyek a magzat optimális anatómiai és élettani fejlődését, valamint a várandósság terminusig történő kihordását biztosítják. selleck products Ezen hatások sokszor a reproduktív szervrendszeren kívül más szerveket is érinthetnek, így a szemet és a szem függelékeit. A szemészeti változások élettani és kóros eltérésekben nyilvánulhatnak meg, melyek a legtöbbször átmenetiek és ártalmatlanok, bizonyos esetben azonban terápiás beavatkozást igényelhetnek, vagy súlyos háttérbetegség kórjelzői lehetnek. Közleményünkben áttekintjük a terhességhez kapcsolódó leggyakoribb fiziológiás szemészeti változásokat és egyéb patológiás szemészeti kórképeket, melyek a várandósság alatti megváltozott hormonális, immunológiai és metabolikus hatásokra kialakulhatnak, progrediálhatnak vagy fellángolhatnak. Ezenkívül ismertetjük a szülésvezetés módjának szemészeti indikációból történő eldöntésének vonatkozásait és a szülés kapcsán előforduló szemészeti szö89-2099.
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) as direct bridge-to-transplantation (dBTT) remains controversial. We compared the short- and long-term outcomes of adult patients undergoing urgent heart transplantation (HT) with (dBTT) and without (non-BTT) VA-ECMO support at the time of HT.

Adults who underwent urgent HT in two institutions were assessed (N = 133; dBTT N = 34 and non-BTT N = 99). Patient characteristics, donor characteristics, in-hospital outcomes, and overall survival were compared. Mean follow up was 77±38 months and was 100% complete. Mortality predictors were identified using univariate and multivariate analyses.

Before HT, patients with dBTT had higher rates of ischemic cardiomyopathy, acute kidney injury, liver failure, respiratory failure, and longer graft ischemia times. More patients in the dBTT group had complications, such as requiring VA-ECMO postoperatively (dBTT=50% vs. non-BTT=20%, P < 0.01). Hospital deaths (dBTT=23% vs. non-BTT=19%, P = 0.58), one-year (74% vs. 80%) and five-year survival (62% vs. 75%, P = 0.74 for overall survival) were not significantly different. The MELD-XI score and previous cardiac surgery were independent predictors of hospital mortality.

Direct bridge-to-transplantation in patients on VA-ECMO support was not associated with worse long-term outcomes compared with non-VA-ECMO urgent HT, especially in recipients without any associated organ failure and a low MELD-XI score before HT.
Direct bridge-to-transplantation in patients on VA-ECMO support was not associated with worse long-term outcomes compared with non-VA-ECMO urgent HT, especially in recipients without any associated organ failure and a low MELD-XI score before HT.
The aim of this study was to explore the efficacy and safety of minimally invasive transthoracic closure (MITC) in treating ventricular septal defect (VSD).

A total of 252 children with VSD were investigated between August 2013 and March 2015. Their electrocardiographic indices were monitored at different time points (before surgery [T0], immediately after surgery [T1], and 3 days/7 days/1 month/3 months/6 months after surgery [T2-6]) and followed up every year. Related adverse events also were recorded.

All children with VSD successfully underwent MITC. The average follow-up time was 5 years, during which no changes in the heart rate or corrected QT interval were found. The PR and QRS intervals were prolonged in the early postoperative period (T3); the SV1+RV5 amplitude decreased significantly at T6, and the left axis deviation significantly recovered at T6 (P < 0.05). A total of 32 patients developed arrhythmia within 3 days after surgery; however, no severe arrhythmia, including ventricular tachycardia, ventricular fibrillation, second-and third-degree atrioventricular block, complete left or right bundle branch block, and delayed arrhythmia, occurred during the follow-up period. Binary multivariate logistic regression revealed that the longer the surgery time and the larger the VSD diameter, the higher the risk of arrhythmia.

The incidence of long-term arrhythmia after MITC is low, and the outcomes are good.
The incidence of long-term arrhythmia after MITC is low, and the outcomes are good.
The objective of this prospective study was to evaluate the characteristics (positive and negative) of Perceval S valve in patients undergoing aortic valve replacement with a biological prosthesis. The study included 67 patients operated on at our institution and a mean follow-up period of 18 months.

From June 2016 to November 2019, 209 patients underwent aortic valve replacement with a biological prosthesis. Of these, 67 patients were included in the study based on the exclusion and inclusion criteria set before the study began. Their data were recorded during their hospital stay (preoperative, intraoperative, and early and late postoperative time).

Fifty-four patients underwent isolated aortic valve replacement (group I) with a Perceval S prosthesis, and 13 patients had combined aortic valve replacement procedures and CABG procedures (group II). Patients were implanted with the following prosthesis sizes S (N = 12), M (N = 18), L (N = 28), or XL (N = 9). The Perceval S valve successfully was implanted in 67 (91.8%) patients (in 6 patients, the preoperative transthoracic echocardiographic data did not coincide with intraoperative TEE and surgical measurement of the size of the annulus in the suture). Surgical approaches in patients were medial sternotomy (N = 48), mini sternotomy (N = 15), and thoracotomy through the second intercostal space to the right (N = 4). The mean clamping time of the aorta and CPB length for isolated cases was 54 and 82 minutes, respectively, and 96 and 120 minutes for combined procedures. Four (5.9%) patients died within 30 days.

Early postoperative results showed that the Perceval S valve was safe. Further follow up is required to evaluate the long-term duration of patients with this bioprosthesis.
Early postoperative results showed that the Perceval S valve was safe. Further follow up is required to evaluate the long-term duration of patients with this bioprosthesis.Ascending thoracic aortic aneurysms are rare in childhood and typically are seen in the setting of connective tissue defect syndromes. These aneurysms may lead to rupture, dissection, or valvular insufficiency, so root replacement is recommended. Here, we present a 17-month-old girl who presented with fever, cough, and pericardial effusion. Initially, we suspected this could be a COVID-19 case, so a nasopharyngeal swap was performed. An ascending aorta aneurysm involving the aortic arch was confirmed by echo, and urgent ascending aorta and arch replacement were done by utilizing the descending aorta as a new arch. The final diagnosis came with cutis laxa syndrome. In similar cases, good outcomes can be achieved with accurate diagnosis and appropriate surgical management.
Intractable bleeding from the apical cannulation site of a left ventricular assist device (LVAD) is a dreaded complication.

A 52-year-old male suffering from dilative cardiomyopathy (DCM) with fixed pulmonary hypertension underwent reoperative LVAD implantation after previous mitral valve surgery. The patient underwent three rethoracotomies for bleeding from the apex cannulation site without achieving hemostasis. Conventional techniques and application of fibrin sealants and polymeric sealing devices did not fix the problem. The bleeding stopped after application of the EVARREST® Fibrin Sealant Patch (FSP), and he needed no further transfusions.

This patch might become a useful tool for intractable bleeding problems in LVAD surgery.
This patch might become a useful tool for intractable bleeding problems in LVAD surgery.
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