Notes

The A number of Tasks from the Cytosolic Card Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Situations.
t affect their prescription.
Adequate compressive strength is an important characteristic for an ideal liner.

This study aimed to assess the compressive strength of several commonly used liners.

This in vitro, experimental study evaluated 120 samples fabricated of Dycal, Calcimol LC, Vitrebond, Activa Bioactive, and TheraCal LC (n=24) liners according to the manufacturers' instructions. The samples were fabricated using a cylindrical stainless steel mold with 6±0.1 mm height and 4±0.1 mm internal diameter. Selleckchem Vismodegib Half of the samples in each group (n=12) underwent compressive strength test immediately after completion of their primary setting while the other half (n=12) underwent compressive strength test after 24 h. During this period, the samples were immersed in deionized water (grade 3) and incubated at 37±1°C and 100% humidity for 24 h. The compressive strength was measured using a universal testing machine. Data were analyzed using two-way ANOVA followed by Tukey's post-hoc test.

The compressive strength of the five liners was significantly different (p< 0.05). Calcimol LC showed maximum compressive strength both immediately after setting and after 24 h. The compressive strength at 24 h was significantly higher than the primary compressive strength in all groups (p< 0.05).

Within the limitations of this study, it seems that Calcimol LC, Activa Bioactive Liner, and TheraCal LC have adequate compressive strength and can be used alone to provide adequate support for the restorative materials.
Within the limitations of this study, it seems that Calcimol LC, Activa Bioactive Liner, and TheraCal LC have adequate compressive strength and can be used alone to provide adequate support for the restorative materials.
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Early diagnosis of OSCC by using biomarkers provides preventive treatment approach to suppress the disease in early stages. CD44 as a cancer stem cell (CSC) marker may be cleaved by MT1-MMP and plays an important role in migration of cancer cells. TGF-B promotes formation of invasive cancer cells phenotype through epithelial mesenchymal transition (EMT) and induces MT1-MMP formation.

The aim of this study was to evaluate the expression of TGF-B and CD44 in leukoplakia (premalignant lesion), squamous cell carcinoma (SCC), and normal oral mucosa to determine the role of these markers in the carcinogenesis process of the oral mucosa.

In this retrospective study, the expression of TGF-B and CD44 were evaluated in 55 paraffin-embedded specimens (10normal mucosa, 15 non-dysplastic leukoplakia, 15 dysplastic leukoplakia, and 15 OSCC) by immunohistochemistry. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitnr and TGF-B as an EMT marker from normal mucosa to non-dysplastic leukoplakia, dysplastic leukoplakia, and OSCC and also the significant correlation between these two markers indicated their role in carcinogenesis of oral mucosa.
Adolescents are at risk of obesity and caries due to various factors such as diet and poor health habits; these factors may affect their body mass index (BMI) and salivary components. Therefore, it is necessary to assess these factors and their relationship in this age group.

This study aimed to evaluate the association between decayed missing filled teeth index (DMFT), salivary alpha amylase (sAA) level and age-specific BMI in adolescent girls.

A cross-sectional study was conducted on 81 females aged 13-15 years in 3 groups of BMI percentiles; "normal", "at risk for overweight" and "overweight" (n=27). DMFT was calculated and unstimulated saliva samples were collected. The sAA level was measured with a spectrophotometer. Data were analyzed using Kolmogorov-Smir-nov test, Kruskal- Wallis and Spearman correlation tests using SPSS (version 23) at
< 0.05.

The concentration of sAA and mean DMFT were estimated 1326.56±4.73 U/L and 2.77±2.36, respectively. There was no significant difference in sAA level and mean DMFT among BMI groups. A positive and significant correlation was found between sAA and DMFT in overweight group (r 0.46,
= 0.014).

Within the limitation of this study, higher levels of sAA may be considered as an indicator for dental caries in overweight adolescent girls.
Within the limitation of this study, higher levels of sAA may be considered as an indicator for dental caries in overweight adolescent girls.
The success of metal-ceramic restorations depends on the bond strength between porcelain and alloy. These restorations can be fabricated through different casting and computer-aided design/computer-aided manufacturing (CAD/CAM) techniques.

This study aimed to compare the bond strength of porcelain to milled sintered (Sintron) and casting (Co-Cr and Ni-Cr) base metal alloys.

In this
experimental study, 63 rectangular bars (25×3×0.5 mm) were fabricated of three base metal alloys casting Ni-Cr, casting Co-Cr, and milled sintered Co-Cr alloy. Feldspathic porcelain (3×8 mm) was applied at the center of each bar with 1.5 mm thickness. The specimens were thermally aged. Bond strength was evaluated through three-point flexural test. Failure mode was evaluated by optical and electron microscope. Data were analyzed with one-way ANOVA and Tukey's post hoc test (α=0.05).

The mean flexural bond strength of porcelain to milled sintered Co-Cr alloy (24.58±5.16 MPa) was significantly higher than that of casting Ni-Cr (21.13±6.34 MPa) (
0.03) and casting Co-Cr (20.98±4.84 MPa) alloys (
0.04). However, the two casting alloys were not significantly different in this regard (
0.93). The failure mode in all specimens was of cohesive type.

Bond strength of CAD/CAM milled sintered Co-Cr alloy was better than that of the conventional casting alloys and could serve as a suitable alternative to those alloys.
Bond strength of CAD/CAM milled sintered Co-Cr alloy was better than that of the conventional casting alloys and could serve as a suitable alternative to those alloys.
Alveolar bone resorption associated with periodontal disease is a common finding and generally irreversible. It impairs mastication and causes esthetic problems for patients. Bisphosphonates are the most commonly used antiresorptive agents for bone diseases.

Considering the risk of bisphosphonate-related osteonecrosis of the jaw, this study aimed to assess the effect of 2% risedronate gel on calvarial bone defects in rabbits.

In this animal study, critical-size defects of 8mm were created in the calvaria of 20 New Zealand white rabbits. In group 1 (n=10), 2% risedronate gel was applied into the right side defect while the left side defect remained empty and served as control. In group 2 (n=10), placebo gel was applied into the right side defect, while the left side defect remained empty and served as control. Five rabbits in each group were sacrificed at 1month and the remaining five at 2 month, post-operatively, and tissue samples were collected for histomorphometric analysis. Histomorphometric assessments included bone fill, degree of inflammation, number of osteoblasts, number of osteoclasts, and foreign body reaction at the site.
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