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t function and is a potent biomarker for the long-term prognosis of graft function.
uKIM-1 on the first day post transplantation can predict short-term graft function and is a potent biomarker for the long-term prognosis of graft function.
Obstructive sleep apnea (OSA) is associated with insulin resistance. However, the association between special stages of OSA [rapid eye movement (REM) sleep] and insulin resistance is not clear. This study was designed to assess the association of the frequency of respiratory events during REM sleep with insulin resistance in adults with suspected OSA.
In this cross-sectional study, 4,062 adult participants with suspected OSA who underwent polysomnography in our sleep center between 2009 and 2016 were screened. Polysomnographic variables, biochemical indicators, and physical measurements were collected. check details Logistic regression analyses were conducted to determine the odds ratios (ORs) and 95% confidence intervals (95% CIs) for insulin resistance as assessed by the presence of hyperinsulinemia, the homeostasis model assessment of insulin resistance (HOMA-IR) index, the fasting insulin resistance index (FIRI), and Bennett's insulin sensitivity index (ISI).
The final analyses included 2,899 adults with suspecteand Bennett's ISI in adults with suspected OSA. Additionally, REM sleep duration was independently associated with hyperinsulinemia.
AHIREM was independently associated with hyperinsulinemia and an abnormal HOMA-IR, FIRI, and Bennett's ISI in adults with suspected OSA. Additionally, REM sleep duration was independently associated with hyperinsulinemia.
Machine learning was used to predict subretinal fluid absorption (SFA) at 1, 3 and 6 months after laser treatment in patients with central serous chorioretinopathy (CSC).
The clinical and imaging data from 480 eyes of 461 patients with CSC were collected at Zhongshan Ophthalmic Center (ZOC) and Xiamen Eye Center (XEC). The data included clinical features from electronic medical records and measured features from fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), optical coherence tomography angiography (OCTA), and optical coherence tomography (OCT). A ZOC dataset was used for training and internal validation. An XEC dataset was used for external validation. Six machine learning algorithms and a blending algorithm were trained to predict SFA in patients with CSC after laser treatment. The SFA results predicted by machine learning were compared with the actual patient prognoses. Based on the initial detailed investigation, we constructed a simplified model using fewer clinical features and OCT features for convenient application.
During the internal validation, random forest performed best in SFA prediction, with accuracies of 0.651±0.068, 0.753±0.065 and 0.818±0.058 at 1, 3 and 6 months, respectively. In the external validation, XGBoost performed best at SFA prediction with accuracies of 0.734, 0.727, and 0.900 at 1, 3 and 6 months, respectively. The simplified model showed a comparable level of predictive power.
Machine learning can achieve high accuracy in long-term SFA predictions and identify the features relevant to CSC patients' prognoses. Our study provides an individualized reference for ophthalmologists to treat and create a follow-up schedule for CSC patients.
Machine learning can achieve high accuracy in long-term SFA predictions and identify the features relevant to CSC patients' prognoses. Our study provides an individualized reference for ophthalmologists to treat and create a follow-up schedule for CSC patients.
The quantitative measurement of the anticipated number of disaster deaths is very important shortly after the mainshock because the forecasted fatalities could help determine the size of the health and medical services team to be deployed. This study aimed to devise a simple method to predict the cumulative number of deaths during the immediate or early stage of a large earthquake.
We analyzed six earthquakes in Japan that involved at least 20 deaths, 1990-2018. Analyzing statistical patterns in the cumulative number of deaths, we used three models-the exponential model, the Weibull model, and the percentile-based model-to predict the likely number of deaths during the early stage of earthquakes.
The median time required to reach the median number of deaths was 2.2 (interquartile range 1.5, 3.8) days from the mainshock. By only multiplying the cumulative number of deaths as on day 2 by a factor of two, the likely number of deaths was calculated using the percentile-based method. The validity of this simple method was better than the results from day 4 using the parametric models. The Great East Japan earthquake was exceptionally large and difficult to predict in real time, and it involved a large number of fatalities following a tsunami.
For all other earthquakes, the median number of deaths was reached on day 2. Even in a setting with poor technical resources, the predicted number of deaths can be obtained by multiplying the reported cumulative number on day 2 by a factor of two.
For all other earthquakes, the median number of deaths was reached on day 2. Even in a setting with poor technical resources, the predicted number of deaths can be obtained by multiplying the reported cumulative number on day 2 by a factor of two.
The treatment of post-facial palsy synkinesis (PFPS) remains inadequate. Previous studies have confirmed that brain plasticity is involved in the process of functional restoration. Isolated activation has been well studied, however, the brain works as an integrity of several isolated regions. This study aimed to assess the alteration of the brain network topology with overall and local characteristics of information dissemination. Understanding the neural mechanisms of PFPS could help to improve therapy options and prognosis.
Patients with facial synkinesis and healthy controls (HCs) were estimated using functional magnetic resonance imaging (fMRI) of resting-state. Subsequently, an independent component analysis (ICA) was used to extract four subnets from the whole brain. Then we used the measurements of graph theory and calculated in the whole-brain network and each sub-network.
We found no significant difference between the patient group and the HCs on the whole-brain scale. Then we identified four subnetworks from the resting-state data.
Homepage: https://www.selleckchem.com/
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