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BACKGROUND Previous trials have suggested that elderly patients with non-small-cell lung cancer (NSCLC) could benefit from nanoparticle albumin-bound paclitaxel (nab-paclitaxel). Real-world data on the elderly Chinese population are lacking. This study aimed to analyze the effectiveness and tolerability of nab-paclitaxel in Chinese elderly patients (≥65 years) with advanced NSCLC. METHODS This study included 76 patients with a primary diagnosis of IIIB-IV NSCLC from January 2010 to December 2017 at Peking University Cancer Hospital, who received nab-paclitaxel (125 or 130 mg/m2 i.v.) every three weeks. The overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) were analyzed. RESULTS There were 12 patients who received nab-paclitaxel as the first-line treatment (seven also received carboplatin), and 64 received nab-paclitaxel as the latter-line treatment. The overall ORR, DCR, median PFS, and median OS were 14.5%, 69.7%, 5.2 madverse events. What this study adds Preliminary evidence shows a good clinical response from treatment with nab-paclitaxel in Chinese elderly patients with advanced NSCLC. © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.PURPOSE To examine the effects of age, sex, and left ventricular global function on velocity, helicity, and 3D wall shear stress (3D-WSS) in the aorta of N = 100 healthy controls. METHODS Fifty female and 50 male volunteers with no history of cardiovascular disease, with 10 volunteers per age group (18-30, 31-40, 41-50, 51-60, and 61-80 years) underwent aortic 4D-flow MRI. Quantification of systolic aortic peak velocity, helicity, and 3D-WSS distribution and the calculation of age group-averaged peak systolic velocity and 3D-WSS maps ("atlases") were computed. Age-related and sex-related changes in peak velocity, helicity, and 3D-WSS were computed and correlated with standard metrics of left ventricular function derived from short-axis cine MRI. RESULTS No significant differences were found in peak systolic velocity or 3D-WSS based on sex except for the 18- to 30-year-old group (males 8% higher velocity volume and 3D-WSS surface area). Between successively older groups, systolic velocity decreased (13%, 0.35, P less then .001). Arch and descending aorta systolic mean velocity, mean 3D-WSS, and median helicity increased with normalized left ventricular volumes end diastolic volume (r = 0.31-0.37, P less then .01), end systolic volume (r = 0.27-0.35, P less then .01), and stroke volume (r = 0.28-0.35, P less then .01). CONCLUSION Healthy aortic hemodynamics are dependent on subject age, and correlate with vessel diameter and cardiac function. © 2020 International Society for Magnetic Resonance in Medicine.Conjugated microporous polymers (CMPs) have been heralded as promising energy storage materials with advantages such as chemical flexibility, porous structure and environmentally friendliness. Herein, we synthesized a novel conjugated microporous polymer by integrating triazine, thiophene and benzothiadiazole into a polymer skeleton and investigated the Li + ions storage performance for the as-synthesized polymer anode in Li-ion batteries (LIBs). Benefiting from the inherent large surface area, plentiful redox-active units and the hierarchical porous structure, the polymer anode delivers a high Li + ions storage capacity up to 1599 mAh g - 1 at a current rate of 50 mA g - 1 with an excellent rate behavior (363 mAh g - 1 at 5 A g - 1 ), and a long-term cyclability of 326 mAh g - 1 over 1500 cycles at 5 A g - 1 , implying that the newly developed polymer anode offers a great prospect for the next-generation LIBs. © 2020 WILEY-VCH Verlag GmbH & Co. BAY 2416964 nmr KGaA, Weinheim.Synthesis, characterization, electrochemistry, and photophysics of novel homo- and heteroleptic ruthenium(II) complexes [Ru(cpmp)2]2+ (22+) and [Ru(cpmp)(ddpd)]2+ (32+) bearing the tridentate ligands 6,2''-carboxypyridyl-2,2'-methylamine-pyridyl-pyridine (cpmp) and N,N'-dimethyl-N,N'-dipyridin-2-ylpyridine-2,6-diamine (ddpd) are reported. The complexes possess one (32+) or two (22+) electron-deficient dipyridyl ketone fragments as electron accepting sites enabling intraligand charge transfer (ILCT), ligand-to-ligand charge transfer (LL'CT) and low-energy metal-to-ligand charge transfer (MLCT) absorptions. The latter peak around 544 nm (green light). 22+ shows 3MLCT phosphorescence in the red to near-infrared spectral region at room temperature in deaerated acetonitrile solution with an emission quantum yield of 1.3% and a 3MLCT lifetime of 477 ns, while 32+ is much less luminescent. This different behaviour is ascribed to the energy gap law and the shape of the parasitic excited 3MC state potential energy surface. This study highlights the importance of the excited state energies and geometries for the actual excited state dynamics. Aromatic and aliphatic amines reductively quench the excited state of 22+ paving the way to photocatalytic applications using low-energy green light as exemplified with the green-light sensitized thiol-ene click reaction. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Children and adolescents with a lower socioeconomic position have poorer dietary behaviours compared to their counterparts with a higher socioeconomic position. A better understanding of the mechanisms behind such socioeconomic inequalities is vital to identify targets for interventions aimed at tackling these inequalities. This systematic review aimed to summarize existing evidence regarding the mediators of socioeconomic differences in dietary behaviours among youth. A systematic literature search of MEDLINE, Embase, PsycINFO, and Web of Science databases yielded 20 eligible studies. The dietary behaviours included in the reviewed studies were the intake of fruit and vegetables, sugar-sweetened beverages, unhealthy snacks/fast food and breakfast. The consistent mediators of the effects of socioeconomic position on dietary behaviours among youth were self-efficacy, food preferences and knowledge at the intrapersonal level; and availability and accessibility of food items at home, food rules and parental modelling at the interpersonal level.
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