Notes

PEG modified graphene oxide loaded with EALYLV peptides regarding inhibiting your aggregation associated with hIAPP related to type-2 diabetes.
The existence of a causal relationship between the raise of death rate in COVID-19 infected patients and their sufferance from non-communicable pathophysiological conditions, particularly chronic diseases was recently evidenced. In fact, in addition to the immunodeficiency generated by chronic diseases conditions, COVID-19 led also to affect the immune system. Furthermore, the novel coronavirus attacks the lungs and other vital organs such as heart, kidneys, and brain. All these outcomes are accused to be involved in the increasing vulnerability and comorbidity in COVID-19-infected people with chronic diseases. Pharmacological, dietetic and natural approaches were suggested after a deep bibliographic research for presenting preventive recommendations for this category of patients in order to avoid the fatal complications of this infection, and consequently limiting the risk of comorbidity. In this regard, some medications could enter in interaction with COVID-19 infection in patients with diabetes or hypertension and thereafter lead to fatal complications. Furthermore, regarding their nutritional values some foods are more useful than others during this pandemic period because they are rich on vitamins, minerals, antioxidants and perhaps on some bioactive phytochemicals which are known be effective in improving immune response, managing chronic diseases and/or having antiviral activities. In addition, vitamins, minerals, antioxidants, prebiotics and probiotics could be helpful in these conditions. Interestingly, in order to understand the mechanism of this causality and suggesting efficacious solutions, this review deserves considerable epidemiologic, clinical and experimental investigations.The objective of this review was to answer two critical questions in the cell-based bone defect therapies that were as follows 1) does cell therapy associate with the increase in the occurrence of adverse events in the patients compared to control groups, 2) does the use of various cell therapy approaches, including more-than minimal manipulation (MMM) and minimal manipulation (MM), affect the occurrence of adverse events?. An electronic literature search was performed in five databases. The controlled clinical trial studies were selected according to the eligibility criteria. Then, they were categorized into MMM and MM approaches, and a meta-analysis of the controlled clinical trials on the occurrence of adverse events was conducted. MitoQ 23controlled clinical trials, including 10 MMM (n=341 patients) and 13 MM (n=503 patients) approaches were assessed in this study. Bone defects were oral-maxillofacial defects (7MMM and 8MM), osteonecrosis of the femoral head (1MMM and 5MM), long bone shaft fracture (1MMM), and bone defect during revision total hip arthroplasty (1MMM). Cells were isolated from various tissues such as bone marrow (5MMM and 10MM), the dental pulp (2MMM and 2MM), adipose tissue (2MMM), periosteum (1MMM), and peripheral blood (1MMM). Notably, the adverse events were reported in 37, and 3 patients in MMM and MM approaches, respectively. A meta-analysis demonstrated that there was no association between cell therapy and the occurrence of adverse events. Also, the MMM approach (OR 1.46) has a higher chance of the occurrence of adverse events compared to the MM approach (OR 0.71). These results suggested that cell therapy, specifically the MM approach, is safe to improve bone regeneration. Also, future systematic reviews should evaluate the efficacy of these cell therapy approaches.
Poisoning is one of the leading causes of childhood morbidity and mortality worldwide. Despite the advancement of poison detection by modern investigation methods, the clinical skill of toxidrome recognition by combining the findings from a detailed history, thorough physical examination, and the results of basic investigations is still indispensable for the management of children with suspected poisoning.

To review pediatric toxidromes and poisoning management.

A literature search was conducted on PubMed (between February 1 and 15, 2020) with keywords of 'toxidrome' 'poisoning' 'intoxication" "children" and 'pediatric'. The search was customized by applying the appropriate filters so as to get the most relevant articles to meet the objective of this review article.

Toxidrome recognition may help to offer a rapid guide to possible toxicology diagnosis, so that specific antidote can be administered in a timely manner. This article discusses a few commonly encountered toxidromes in pediatric poisoning, y. Physicians should be familiar with common toxidromes and poisoning management.
Fructose has been widely used for producing lower post-infusion glucose increase than other carbohydrates, but seems that it promotes an increase in post-infusion triglycerides.

The present study investigated the effects of fructose and glucose in metabolic variables and appetite sensations in patients with type 1 diabetes mellitus (T1DM).

This is a single-blind, randomized and crossover study (washout of 1-5 weeks), which has evaluated 16 adult T1DM patients, accompanied at University Hospital. After eight hours overnight fasting, were assessment of capillary blood glucose, anthropometric variables, appetite sensations and laboratory tests (glycemia, lipemia, leptin and glucagon). Subsequently, they received 200mL of solutions with water and 75g of crystal fructose or glucose. Appetite sensations and capillary blood glucose were evaluated in different post-infusion times. Blood was drawn after 180 minutes for the laboratory tests.

Blood glucose increased after the intake of both solutions, but the glucose induced a higher elevation. None of them increased triglycerides or glucagon. Glucagon maintenance was similar among the solutions. Furthermore, both solutions reduced leptin and increased fullness, but only fructose increased lack of interest in eating sweets.

Fructose induced smaller increase in postprandial blood glucose than glucose, without changes in triglycerides and glucagon. In addition, leptin levels and appetite sensations were similar to glucose. Other studies are needed in order to confirm these findings, especially in the long term, so that their use becomes really reliable.
Fructose induced smaller increase in postprandial blood glucose than glucose, without changes in triglycerides and glucagon. In addition, leptin levels and appetite sensations were similar to glucose. Other studies are needed in order to confirm these findings, especially in the long term, so that their use becomes really reliable.
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