Notes

Protocol with regard to 'virtual presence': any qualitative review in the ethnic dialectic involving being alone and technology.
Our first-principle kinetic derivation may thus provide an explanation for the slower-than-adiabatic temperature decline in the solar wind. More broadly, it may be useful for describing magnetized collisionless winds from G-type stars.What can humans compute in their heads? We are thinking of a variety of cryptographic protocols, games like sudoku, crossword puzzles, speed chess, and so on. For example, can a person compute a function in his or her head so that an eavesdropper with a powerful computer-who sees the responses to random inputs-still cannot infer responses to new inputs? To address such questions, we propose a rigorous model of human computation and associated measures of complexity. We apply the model and measures first and foremost to the problem of 1) humanly computable password generation and then, consider related problems of 2) humanly computable "one-way functions" and 3) humanly computable "pseudorandom generators." The theory of human computability developed here plays by different rules than standard computability; the polynomial vs. exponential time divide of modern computability theory is irrelevant to human computation. In human computability, the step counts for both humans and computers must be more concrete. As an application and running example, password generation schemas are humanly computable algorithms based on private keys. Humanly computable and/or humanly usable mean, roughly speaking, that any human needing-and capable of using-passwords can if sufficiently motivated generate and memorize a secret key in less than 1 h (including all rehearsals) and can subsequently use schema plus key to transform website names (challenges) into passwords (responses) in less than 1 min. Moreover, the schemas have precisely defined measures of security against all adversaries, human and/or machine.Prior work finds a diversity paradox Diversity breeds innovation, yet underrepresented groups that diversify organizations have less successful careers within them. Does the diversity paradox hold for scientists as well? We study this by utilizing a near-complete population of ∼1.2 million US doctoral recipients from 1977 to 2015 and following their careers into publishing and faculty positions. Cerdulatinib clinical trial We use text analysis and machine learning to answer a series of questions How do we detect scientific innovations? Are underrepresented groups more likely to generate scientific innovations? And are the innovations of underrepresented groups adopted and rewarded? Our analyses show that underrepresented groups produce higher rates of scientific novelty. However, their novel contributions are devalued and discounted For example, novel contributions by gender and racial minorities are taken up by other scholars at lower rates than novel contributions by gender and racial majorities, and equally impactful contributions of gender and racial minorities are less likely to result in successful scientific careers than for majority groups. These results suggest there may be unwarranted reproduction of stratification in academic careers that discounts diversity's role in innovation and partly explains the underrepresentation of some groups in academia.Archaeological studies estimate the initial settlement of Samoa at 2,750 to 2,880 y ago and identify only limited settlement and human modification to the landscape until about 1,000 to 1,500 y ago. At this point, a complex history of migration is thought to have begun with the arrival of people sharing ancestry with Near Oceanic groups (i.e., Austronesian-speaking and Papuan-speaking groups), and was then followed by the arrival of non-Oceanic groups during European colonialism. However, the specifics of this peopling are not entirely clear from the archaeological and anthropological records, and is therefore a focus of continued debate. To shed additional light on the Samoan population history that this peopling reflects, we employ a population genetic approach to analyze 1,197 Samoan high-coverage whole genomes. We identify population splits between the major Samoan islands and detect asymmetrical gene flow to the capital city. We also find an extreme bottleneck until about 1,000 y ago, which is followed by distinct expansions across the islands and subsequent bottlenecks consistent with European colonization. These results provide for an increased understanding of Samoan population history and the dynamics that inform it, and also demonstrate how rapid demographic processes can shape modern genomes. Copyright © 2020 the Author(s). Published by PNAS.Niemann-Pick type C1 (NPC1) disease is a rare genetic condition in which the function of the lysosomal cholesterol transporter NPC1 protein is impaired. Consequently, sphingolipids and cholesterol accumulate in lysosomes of all tissues, triggering a cascade of pathological events that culminate in severe systemic and neurological symptoms. Lysosomal cholesterol accumulation is also a key-factor in the development of atherosclerosis and non-alcoholic steatohepatitis (NASH). In these two metabolic diseases, the administration of plant stanol esters has been shown to ameliorate cellular cholesterol accumulation and inflammation. Given the overlap of pathological mechanisms among atherosclerosis, NASH and NPC1 disease, we sought to investigate whether dietary supplementation with plant stanol esters improves the peripheral features of NPC1 disease. To this end, we used an NPC1 murine model featuring an Npc1 null allele (Npc1nih ), creating a dysfunctional NPC1 protein. Npc1nih mice were fed a two or six percent plant stanol esters-enriched diet over the course of 5 weeks. During this period, hepatic and blood lipid and inflammatory profiles were assessed. Npc1nih mice fed the plant stanol-enriched diet exhibited lower hepatic cholesterol accumulation, damage and inflammation than regular chow-fed Npc1nih mice. Moreover, plant stanol consumption shifted circulating T-cells and monocytes in particular towards an anti-inflammatory profile. Overall, these effects were stronger following dietary supplementation with 6% stanols, suggesting a dose-dependent effect. The findings of our study highlight the potential use of plant stanols as an affordable complementary means to ameliorate disorders in hepatic and blood lipid metabolism and reduce inflammation in NPC1 disease. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.
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