Notes

Altered N-glycosylation modulates TgrB1- and TgrC1-mediated advancement although not allorecognition throughout Dictyostelium.
The research examined user reviews and used content analysis to understand patients' views on the effectiveness of online counseling methods, which supplement the current research gap through innovation in research methods.
The research examined user reviews and used content analysis to understand patients' views on the effectiveness of online counseling methods, which supplement the current research gap through innovation in research methods.
Secondary use of Electronic Health Records (EHRs) has mostly focused on health conditions (diseases and drugs). Function is an important health indicator in addition to morbidity and mortality. Nevertheless, function has been overlooked in accessing patients' health status. see more The World Health Organization (WHO)'s International Classification of Functioning, Disability and Health (ICF) is considered the international standard for describing and coding function and health states. We pioneer the first comprehensive analysis and identification of functioning concepts in the Mobility domain of the ICF.

Using physical therapy notes at the National Institutes of Health's Clinical Center, we induced a hierarchical order of mobility-related entities including 5 entities types, 3 relations, 8 attributes, and 33 attribute values. Two domain experts manually curated a gold standard corpus of 14,281 nested entity mentions from 400 clinical notes. Inter-annotator agreement (IAA) of exact matching averaged 92.3 % F1-scoreimilar fashion.
The data quality of electronic health records (EHR) has been a topic of increasing interest to clinical and health services researchers. One indicator of possible errors in data is a large change in the frequency of observations in chronic illnesses. In this study, we built and demonstrated the utility of a stacked multivariate LSTM model to predict an acceptable range for the frequency of observations.

We applied the LSTM approach to a large EHR dataset with over 400 million total encounters. We computed sensitivity and specificity for predicting if the frequency of an observation in a given week is an aberrant signal.

Compared with the simple frequency monitoring approach, our proposed multivariate LSTM approach increased the sensitivity of finding aberrant signals in 6 randomly selected diagnostic codes from 75 to 88% and the specificity from 68 to 91%. We also experimented with two different LSTM algorithms, namely, direct multi-step and recursive multi-step. Both models were able to detect the aberrant signals while the recursive multi-step algorithm performed better.

Simply monitoring the frequency trend, as is the common practice in systems that do monitor the data quality, would not be able to distinguish between the fluctuations caused by seasonal disease changes, seasonal patient visits, or a change in data sources. Our study demonstrated the ability of stacked multivariate LSTM models to recognize true data quality issues rather than fluctuations that are caused by different reasons, including seasonal changes and outbreaks.
Simply monitoring the frequency trend, as is the common practice in systems that do monitor the data quality, would not be able to distinguish between the fluctuations caused by seasonal disease changes, seasonal patient visits, or a change in data sources. Our study demonstrated the ability of stacked multivariate LSTM models to recognize true data quality issues rather than fluctuations that are caused by different reasons, including seasonal changes and outbreaks.Microplastic pathways in the environment must be better understood to help select appropriate mitigation strategies. In this 2-year long field study, microplastics were characterized and quantified in urban stormwater runoff and through a bioretention cell, a type of low impact development infrastructure. Concentrations of microparticles ranged from below the detection limit to 704 microparticles/L and the dominant morphology found were fibers. High rainfall intensity and longer antecedent dry days resulted in larger microparticle concentrations. In addition, atmospheric deposition was a source of microplastics to urban runoff. Overall, these results demonstrate that urban stormwater runoff is a concentrated source of microplastics whose concentrations depend on specific climate variables. The bioretention cell showed an 84% decrease in median microparticle concentration in the 106-5,000 µm range, and thus is effective in filtering out microplastics and preventing their spread to downstream environments. Altogether, these results highlight the large contribution of urban stormwater runoff to microplastic contamination in larger aquatic systems and demonstrate the potential for current infiltration-based low impact development practices to limit the spread of microplastic contamination downstream.Foaming is a common operational problem in anaerobic digestion (AD) systems, where hydrophobic filamentous microorganisms are usually considered to be the major cause. However, little is known about the identity of foam-stabilising microorganisms in AD systems, and control measures are lacking. This study identified putative foam forming microorganisms in 13 full-scale mesophilic digesters located at 11 wastewater treatment plants in Denmark, using 16S rRNA gene amplicon sequencing with species-level resolution and fluorescence in situ hybridization (FISH) for visualization. A foaming potential aeration test was applied to classify the digester sludges according to their foaming propensity. A high foaming potential for sludges was linked to the abundance of species from the genus Candidatus Microthrix, immigrating with the feed stream (surplus activated sludge), but also to several novel phylotypes potentially growing in the digester. These species were classified to the genera Ca. Brevefilum (Ca. B. fermentans) and Tetrasphaera (midas_s_5), the families ST-12K33 (midas_s_22), and Rikenellaceae (midas_s_141), and the archaeal genus Methanospirillum (midas_s_2576). Application of FISH showed that these potential foam-forming organisms all had a filamentous morphology. Additionally, it was shown that concentrations of ammonium and total nitrogen correlated strongly to the presence of foam-formers. This study provided new insight into the identity of putative foam-forming microorganisms in mesophilic AD systems, allowing for the subsequent surveillance of their abundances and studies of their ecology. Such information will importantly inform the development of control measures for these problematic microorganisms.
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