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Dihydroartemisinin-Loaded Chitosan Nanoparticles Slow down the Rifampicin-Resistant Mycobacterium tb through Interfering with the Cellular Wall structure.
Most countries worldwide, especially low- and middle-income countries (LMICs), are facing an increasing prevalence of fast-food consumption and multiple burdens of malnutrition among young adolescents.

To compare the prevalence of fast-food consumption among young adolescents in LMICs.

We used data from the most recent Global School-Based Student Health Survey (2009-2015), which had been collected using a standardized questionnaire. The weighted prevalence and 95% confidential intervals of fast-food consumption were calculated overall and in subgroups stratified by age, sex, and nutritional status. The pooled overall and regional estimates were obtained using a random-effects model. Heterogeneity was assessed using the I2 statistic. The associated risk factors for fast-food consumption were explored using logistic regression analysis.

Our study comprised 153,496 young adolescents (46.90% boys) from 54 LMICs. Overall, approximately 55.2% (51.3-59.1%) of the adolescents consumed fast food at least 1 dayurgent need to prioritize the implementation of healthy-diet promotion programs to improve adolescent health in these countries.This research explores the dissonance between feminist ideology and practice as it manifests in an activist group of intimate partner violence/aggression (IPV/A) survivors under a state coalition on domestic violence serving multiple stakeholders. A gendered organizations framework reveals the activist group resisting paternalism and colonization in their efforts to achieve their goals and maintain their identity. Two-and-a-half years of observational field work reveals a complex dynamic, simultaneously feminist and patriarchal, with the activist group experiencing growing pains and internal conflict, emotion regulation, as well as empowerment. We offer suggestions for further exploration of the ways survivor-activist groups and coalitions can pursue collaborative partnerships.Background Subclinical hypothyroidism is diagnosed based on serum thyrotropin (TSH) reference intervals, which in turn are affected by many factors. Methods Data were acquired from a Chinese nationally representative cross-sectional study of 78,470 participants (TIDE study). The total study population were participants from the TIDE program, and the reference population was a subset of the total population defined by the National Academy of Clinical Biochemistry (NACB) guidelines. Serum concentrations of thyroid hormones, TSH, thyroid antibodies, and urine iodine concentration (UIC) were measured. Results The geometric mean serum TSH (2.5th-97.5th) for the reference population (defined by the NACB) and total population was 2.28 mIU/L (0.74-7.04 mIU/L) and 2.34 mIU/L (0.61-8.33 mIU/L), respectively. In the reference population, increase in UIC was significantly associated with increase in the 50th and 97.5th centiles and decrease in the 2.5th centile of TSH. The median TSH was significantly higher in women than in men (2.41 mIU/L vs. 2.16 mIU/L, p-value less then 0.001). Increased age was significantly associated with an increased TSH, 97.5th centile. For each 10-year increase in the population age, the TSH 97.5th centile increased by 0.534 mIU/L. The prevalence of subclinical hypothyroidism diagnosed according to the assay-recommended interval (Roche 0.27-4.2 mIU/L) and NACB standard interval in the TIDE study (0.74-7.04 mIU/L) differed significantly (Roche 13.61% vs. Monastrol TIDE 3.00%, p  less then  0.05). However, there was no significant difference in future cardiovascular disease, reflected by the Framingham risk score, between the 0.27-4.2 and 4.2-7.04 mIU/L TSH groups. Conclusions Serum TSH concentration significantly increased with increase in iodine intake. Thus, iodine intake must be considered in establishing TSH reference intervals. To avoid overdiagnosis and overtreatment of subclinical hypothyroidism, different areas should use individual serum TSH reference intervals.Fig limb dieback is a cosmopolitan disease caused by Neoscytalidium dimidiatum (Botryosphaeriaceae), characterized by branch and shoot cankers, discoloration of woody tissues, and dieback. The present study investigated the etiology of the disease in California that seems to have become prevalent among fig orchards in the last several years. During orchard surveys in Fresno, Kern, and Madera Counties over 3 years, we isolated consistently and evaluated the pathogenicity of N. dimidiatum under laboratory and field conditions. The effect of summer and winter pruning on the disease severity and the effects of different environmental and mechanical stresses, such as sunburn and wounding by mallets, were assayed. In addition, the susceptibility of six different cultivars and the effects of eradicating cankered shoots from the fig trees as a method to combat the spread of the disease were studied. Pathogenicity tests demonstrated that N. dimidiatum induces cankers on fig, mainly on wounded shoots. Results from the remaining experiments revealed that summer infection leads to more severe canker lesions than those induced by winter infection and that stressed shoots are more susceptible to infection than nonstressed shoots. 'Brown Turkey', 'Conadria', and 'Calimyrna' cultivars (all nonpersistent figs, i.e., needing pollination for fruit development) were less susceptible than the more susceptible 'Kadota', 'Sierra', and 'Black Mission' (all persistent figs, i.e., not needing pollination for fruit development). Canker removal from the orchard seems to be a good agronomic practice to avoid the spread of disease.Botrytis cinerea on grapes causes bunch rot at both pre- and postharvest stages, in which losses can reach up to 100%. Chemical control primarily relies on the prophylactic use of site-specific fungicides. Repeated applications of these products raise the risk of fungicide resistance development in B. cinerea populations, which can result in disease control failures. To determine the extent of resistance, B. cinerea isolates were collected from grape clusters in the northwest and southwest grape growing regions of Michigan in 2014 and 2018 (n = 115 and 125, respectively). These isolates were phenotyped using discriminatory doses of eight fungicides to determine the levels of resistance. Fungicide resistance increased from 2014 to 2018, mostly affecting the active ingredients fenhexamid, fluopyram, and iprodione. B. cinerea isolates resistant to multiple fungicides were detected in 2014 and 2018, with a higher frequency of resistance in 2018. TaqMan real-time PCR has been developed to detect B. cinerea fungicide resistance to fenhexamid and to differentiate the erg27 F412S/I/V alleles.
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