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The intake (g/d) of carbohydrates and fibre decreased significantly from baseline to week six (p less then 0.001) as well as on fasting days compared to non-fasting days (p less then 0.001). The intake of calcium, zinc, magnesium and potassium were lower than recommended guidelines. Sodium intake exceeded the suggested daily target. On fasting days, the percent of total energy from protein significantly increased from 21% to 25% (p = 0.02). Despite intake being unrestricted on non-fasting days the energy intake decreased by week six when compared with baseline. CONCLUSION The composition of IF 52 was a high protein, moderate fat, low carbohydrate diet with a low fibre intake. Some micronutrients have lower than recommended intake. However, overall IF 52 is a safe acceptable weight-loss diet strategy. click here BACKGROUND Unhealthy dietary practices, sedentary life style and lack of physical exercise in developing countries like India are major contributors of metabolic syndrome like obesity and diabetes. Obesity in Indians is defined at Body Mass Index (BMI, kg/m2) >25 and characterized as metabolically obese. OBJECTIVE A preliminary study performed to explore ramification of obesity on metabolic profile of adipose tissue and adipose derived stem cells (ADSC) from control and obese Indians. METHODS Adipose tissue/lipoaspirates from both control (BMI ≤ 23) subjects, and non-diabetic obese Indians subjects (BMI ≥ 25), were scrutinized for expressions of lipogenic genes, inflammatory mediators, stored adipokine levels, and insulin signaling proteins. Further, hADSC were isolated and immune-phenotyped from both the subject groups. Comparative assessments between chADSC and ohADSC were carried out for growth kinetics, expressions of pluripotent genes, adipogenic transcriptional factors, RUNX2, inflammatory mediators (IM), insulin signaling proteins, adipogenic and osteogenic differentiation. RESULTS Adipose tissue of obese subjects depicted high leptin and resistin levels with reduced adiponectin levels. Expressions of IM and insulin signaling proteins were elevated compared to those of control subjects. hADSC of obese subjects demonstrated diminished proliferation, altered pluripotent genes, aggravated inflammation, adipogenesis with reduced osteogenesis. hADSC of obese had established insulin resistance compared to those of control subjects. CONCLUSION This is the first study that describes hADSC of metabolically obese Indians have insulin resistance at lower BMI compared to Caucasians exemplifying plausible role in diminishing stemness of hADSC. Study alarms Indians to restore healthy dietary habits and assess quality of hADSC in regenerative therapy. Science fiction is all around us, manifesting in fiction, TV series, blockbuster movies etc. The Star Trek (ST) universe has become an integral element of popular culture and doctors play important roles. This paper introduces depictions of these individuals over the decades since the inception of the series in 1966. The doctors portrayed have reflected the shifting expectations of the general public in that medics have morphed successively from an old-style country doctor, to a single supermom, to a genetically engineered human, to a sentient, computer-generated hologram and to an alien who uses also uses natural healing methods. The doctor in the latest ST series has broken another barrier in that this is the first series to deliberately include homosexual couples within the Star Trek universe for the first time in its fifty-one odd year lifespan and the doctor is the first openly gay character. These doctors are expected to demonstrate total accessibility, the ability to utilise natural remedies when possible, compassion and unstinting commitment to their patients and their profession, infallibility and broad skills with flexibility that allows them to deal with virtually anything, in anyone/anything. These capacities appear desirable even if the traditional doctor is replaced by a machine, a warning for the medical profession. A second collection of papers will further explore the ST universe by analysing unethical medical experimentation, artificial intelligence (AI) and the institution of ethics in AI, the application of nanotechnology in biology and depictions of the nursing profession in this fictive future. V.Science fiction (SF) is ubiquitous and it has also been utilised for the purposes of teaching since it has replaced legend, myth and fable. This is especially the case for Star Trek (ST) which has become an integral part of popular culture, even for those who do not follow SF. In this Best Practice Guideline (BPG) we will engage topics that ordinary readers of EHD might not normally come across, but may well find interesting. We will review the individual doctors in ST from the viewpoint of a medical doctor, and will demonstrate the ways in which the medic in the various series (which spans decades, since 1966) reflects the zeitgeist. A second BPG will provide an assortment of ST cautionary tales which range from nanotechnology, to The Holocaust, to artificial intelligence. SF is famously "extravagant fiction today, cold fact tomorrow" and takes us "where no man has gone before". The imaginings of SF authors (some of whom are scientists and doctors) should be taken seriously for potential detrimental effects/events that may befall the medical profession or the human race, and that might be avoided with the foresight provided by SF. OBJECTIVE Effective communication is fundamental to helping patients change behaviour. Few studies have operationalised how to quantify and improve the patient centeredness of communication during the dietitian outpatient consultation. We sought to evaluate the impact of a renal diet question prompt sheet (QPS) on patient centeredness (PC) in dietitian outpatient clinics and describe the impact of a renal diet QPS on the volume and pattern of communication between dietitians (n = 4) and patients/carers (n = 24, n = 11). METHODS The Roter Interaction Analysis System was used to compute a PC index, the volume communication (number of questions and utterances) and categorise dietitian communication. RESULTS The QPS was associated with significant improvements in the PC of communication (p = 0.004 and p = 0.001), without increasing the volume of communication. The QPS was also associated with an increase in the total number of questions asked (p less then 0.0001) especially from patients (p = 0.0009); and an increase in the volume of communication devoted to education and counselling (p less then 0.
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