Notes

Circulating circRNA as biomarkers for dilated cardiomyopathy etiology.
Conversely, at the same time, they have provided evidence for unexpected effectiveness of other agents that have been underutilized, such as steroids, which were not used in SARS treatment because of the threatened effect on viral replication. Evidence deriving from pathologic studies have demonstrated that the prothrombotic effects of SARS-CoV-2 can be prevented by heparin prophylaxis, underlining the need for personalized treatment for patients with severe disease. The main aim of this review is to synthesize the available information and evidence on both repositioned and experimental drugs for the treatment of COVID-19, focusing on the need to exercise caution on the use of unproven medical therapies.
The COVID-19 pandemic is caused by a severe acute respiratory syndrome coronavirus which emerged in Wuhan. Recently this virus has rapidly spread throughout Ethiopia. The current preventive measure practices and knowledge have gaps. Therefore this study aimed to assess COVID-19 preventive measure practices and knowledge of pregnant women in Guraghe Zone hospitals.

This cross-sectional study was conducted from July 27-August 27, 2020 among pregnant women in Guraghe zone hospitals. Systematic random sampling technique were employed to select 403 participants. Data were checked manually for completeness, cleaned, and stored in Epi Data and exported to SPSS for further analysis. Variables which have a
-value less than 0.25 on bivariate analysis were taken to multivariate analysis. A
-value of less than 0.05 and 95% confidence level was used as a cut-off point for presence of association in multivariate analysis.

COVID-19 preventive measure practice and knowledge of pregnant women visiting Guraghe Zone hVID-19 by their healthcare providers.
Female genital mutilation (FGM) is a harmful practice that causes health-related problems in the life of the affected women and girls. Though FGM is declared as a human right violation, studies revealed it is being practiced throughout Ethiopia. Therefore, this study was conducted to assess the prevalence, trends, and predictors of FGM among reproductive-aged (1549 years) women in Ethiopia.

Trends of FGM among reproductive-age women were estimated using the three Ethiopian Demographic and Health Survey (EDHS) 2000 (n=15,367), 2005 (n=14,070) and 2016 (n=7248) data. Multilevel logistic regression analysis was conducted to identify both individual- and community-level factors of FGM using the latest (2016) EDHS. To adjust potential confounders, the analysis was conducted considering sample weighting, clustering, and stratifications using STATA-14 software.

The prevalence of FGM among women of reproductive age in Ethiopia decreased from 79.91% in 2000 to 70.37% in 2016. Similarly, FGM among daughters of ciwomen over the last 16 years. Education, religion, age, age at marriage, occupation, marital status, and geographical regions were determinants of FGM. Combined and integrated interventions based on the identified factors are recommended to abandon FGM in Ethiopia.
The early onset of skin-to-skin contact encourages the infant to breastfeed within one hour of birth. The aim of this study was to assess the prevalence of early onset breastfeeding and its associated factors among vaginal delivered mothers in hospitals in the South Gondar Zone of Northwest Ethiopia in 2020.

From January 12 to February 03, 2020, an institutional-based cross-sectional study was used in South Gondar Zone hospitals. A total of 356 mothers delivered by vaginal were included. Data wascollected using a questionnaire administered by the interviewer and entered into version 3.1 of EpiData, and then exported to SPSS version 23.0.0. To classify factors correlated with the outcome variables, logistic regression statistical analyses were used.

In the study area, the prevalence of early breastfeeding initiation among vaginally delivered mothers was 88.2%. Mothers who had unintended pregnancy [adjusted OR=6.00, 95% CI=2.8, 12.5], had professional guidance [adjusted OR=2.75, 95% CI=1.2, 5.6] and experience with breastfeeding [adjusted OR=1.79 95% CI=1.19, 2.68] among vaginal delivered mothers were positively correlated with early breastfeeding initiation.

The type of pregnancy and professional guidance among vaginally delivered mothers were significantly associated with early initiation of breastfeeding. LOXO-195 Community-based education and counseling on breastfeeding for pregnant mothers and encouraging all mothers to start early breastfeeding.
The type of pregnancy and professional guidance among vaginally delivered mothers were significantly associated with early initiation of breastfeeding. Community-based education and counseling on breastfeeding for pregnant mothers and encouraging all mothers to start early breastfeeding.
The use of electroconvulsive therapy in pregnancy has been limited by concerns about its effects on fetal well-being, despite limited evidence that suggests it is safe and effective. No studies have utilized continuous fetal heart rate monitoring during electroconvulsive therapy sessions. We aimed to describe the fetal heart rate patterns of patients undergoing electroconvulsive therapy.

This study is a prospective case series of pregnant patients undergoing electroconvulsive therapy with continuous fetal heart rate monitoring.

University-based hospital.

Pregnant patients with a psychiatric indication for electroconvulsive therapy.

Patients underwent fetal heart rate monitoring immediately prior, during and immediately after ECT therapy.

Characterization of the fetal heart rate tracing.

Five subjects underwent 44 electroconvulsive therapy sessions. Continuous fetal monitoring was performed on 34 of the sessions. Transient fetal heart rate decelerations occurred in 4 sessions, all self-resolved and none required intervention.

This case series is the first to report the results of continuous FHR monitoring during electroconvulsive therapy. The most common finding was a transient, self-resolving bradycardia that was not associated with adverse perinatal outcomes. This supports the opinion that electroconvulsive therapy is a safe treatment option in pregnancy in women with severe mental disease.
This case series is the first to report the results of continuous FHR monitoring during electroconvulsive therapy. The most common finding was a transient, self-resolving bradycardia that was not associated with adverse perinatal outcomes. This supports the opinion that electroconvulsive therapy is a safe treatment option in pregnancy in women with severe mental disease.
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