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Maternal Variables because Determining factor of Fetal Expansion: Research Standard protocol about Personalized Fetal Growth Chart within Malaysia (GROW-My).
Sensory data are critical for soft robot perception. Crenolanib However, integrating sensors to soft robots remains challenging due to their inherent softness. An alternative approach is indirect sensing through an estimation scheme, which uses robot dynamics and available measurements to estimate variables that would have been measured by sensors. Nevertheless, developing an adequately effective estimation scheme for soft robots is not straightforward. First, it requires a mathematical model; modeling of soft robots is analytically demanding due to their complex dynamics. Second, it should perform multimodal sensing for both internal and external variables, with minimal sensors, and finally, it must be robust against sensor faults. In this article, we propose a recurrent neural network-based adaptive unscented Kalman filter (RNN-AUKF) architecture to estimate the proprioceptive state and exteroceptive unknown input of a pneumatic-based soft finger. To address the challenge in modeling soft robots, we adopt a data-driven approach using RNNs. Then, we interconnect the AUKF with an unknown input estimator to perform multimodal sensing using a single embedded flex sensor. We also prove mathematically that the estimation error is bounded with respect to sensor degradation (noise and drift). Experimental results show that the RNN-AUKF achieves a better overall performance in terms of accuracy and robustness against the benchmark method. The proposed scheme is also extended to a multifinger soft gripper and is robust against out-of-distribution sensor dynamics. The outcomes of this research have immense potentials in realizing a robust multimodal indirect sensing in soft robots.Our research compares the ethical and institutional conditions that govern the sharing and secondary use of longitudinal population health data from multiple cohorts. The data use and data sharing conditions applicable to 27 population health cohorts were assessed. This assessment was performed in consulting the informed consent materials and institutional policies applicable to the use of data. Descriptions drawn from the research ethics consent materials were refined through dialog with the institutional staff responsible for overseeing access to data, where possible. Our results demonstrate that data of longitudinal population health cohorts assessed can generally be shared and used for secondary purposes. However, the purposes of secondary use and the preconditions applicable thereto are highly variable. Heterogeneous use conditions can also impede the storage of legacy research data and the pooling thereof for the purpose of common reuse.Background Thoracoscopic resection is the standard of care for congenital lung malformations (CLMs) in infants. However, there is rising concern that capnothorax may affect cerebral perfusion and oxygenation, carrying potential long-term effects on neurodevelopmental behavior. The aim of our study was to investigate, using near-infrared spectroscopy (NIRS), the regional cerebral oxygenation (CrSO2) in infants undergoing thoracoscopic lung resection; the secondary aim was to assess the relationship between rSO2 and standard monitoring. Methods In this retrospective study, we reviewed all infants (20% of basal value in 1 patient, during capnothorax induction. Renal NIRS added very little to standard monitoring, which appeared generally inadequate to consistently appraise end-organ perfusion. ETCO2 best correlated with CrSO2 variations, suggesting to be able to realistically predict them. Conclusions The thoracoscopic treatment of CLMs under the given conditions appears well tolerated in infants, pending the continuous adjustment of ventilator settings by an experienced anesthetist, confident with NIRS technology.This study examines digitally enabled mate poaching on Ashley Madison, an online dating platform for extradyadic affairs. To explore mate poaching as a potential explanation for what drives users of Ashley Madison to transition their online relationships to offline encounters, we conducted a multinational survey of 1,676 users (88.5 percent male, Mage = 50.98). Participants provided open-ended data about their mate poaching objectives, which ranged from short-term sexual encounters to long-term sexual and emotional affairs and new exclusive relationships. Structural equation modeling showed that participants' attitudes toward online infidelity predicted whether they would consider meeting someone from the website in person. Mate poaching intentions also mediated the effect of attitudes toward online infidelity on the likelihood of meeting another user face to face in the future. The results extend evolutionary theories of mate poaching to the digital dating environment and demonstrate the value of these perspectives for explaining relationship initiation practices on infidelity websites.
The effect of vericiguat, a novel oral soluble guanylate cyclase stimulator, in patients with heart failure and reduced ejection fraction who had recently been hospitalized or had received intravenous diuretic therapy is unclear.

In this phase 3, randomized, double-blind, placebo-controlled trial, we assigned 5 050 patients with chronic heart failure (New York Heart Association class II, III, or IV) and an ejection fraction of less than 45% to receive vericiguat (target dose 10 mg once daily) or placebo, in addition to guideline-based medical therapy.The primary outcome was a composite of death from cardiovascular causes or first hospitalization for heart failure.

Over a median of 10.8 months, a primary-outcome event occurred in 897 of 2 526 patients (35.5%) in the vericiguat group and in 972 of 2 524 patients (38.5%) in the placebo group (p = 0.02). A total of 691 patients (27.4%) in the vericiguat group and 747 patients (29.6%) in the placebo group were hospitalized for heart failure. Death from cardiovascular causes occurred in 414 patients (16.4%) in the vericiguat group and in 441 patients (17.5%) in the placebo group. The composite endpoint of death from any cause or hospitalization for heart failure occurred in 957 patients (37.9%) in the vericiguat group and in 1 032 patients (40.9%) in the placebo group (p = 0.02). Symptomatic hypotension occurred in 9.1% of the patients in the vericiguat group and in 7.9% of the patients in the placebo group (p = 0.12), syncope occurred in 4.0% of the patients in the vericiguat group and in 3.5% of the patients in the placebo group (p = 0.30).

Among patients with high-risk heart failure, the incidence of death from cardiovascular causes or hospitalization for heart failure was lower among those who received vericiguat than those who received placebo.
Among patients with high-risk heart failure, the incidence of death from cardiovascular causes or hospitalization for heart failure was lower among those who received vericiguat than those who received placebo.
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