Notes

Fluorescent Nanoparticles Produced coming from Genetic make-up, RNA, and also Nucleotides.
in English, Polish WPROWADZENIE Cukrzyca typu 1 (T1DM) jest chorobą metaboliczną, silnie wpływającą na stan zdrowia całego organizmu. W jamie ustnej cukrzyca manifestuje się w postaci kserostomii, gingivitis i periodontitis, ropni przyzębnych, zmian zapalnych błony śluzowej oraz próchnicy. CEL PRACY Ocena intensywności próchnicy oraz stanu przyzębia u dzieci chorych na cukrzycę typu 1. MATERIAŁ I METODY Badanie przeprowadzono w trzech grupach dzieci (10–18 lat) z cukrzycą wyrównaną (WC, HBA ≥ 7,5%) oraz w grupie kontrolnej (GC). Przy użyciu wskaźników analizowano następujące parametry próchnicy (DMFT), higieny jamy ustnej (PI, API) oraz stanu przyzębia (GI, mSBI). WYNIKI W grupie WC stwierdzono najniższe wartości wskaźnika DMFT –3,44, w grupie PC wartość ta wyniosła 5,80, a w grupie kontrolnej 3.88. Wartość istotną statystycznie odnotowano między grupami PC i WC (p = 0,04). Wartości pozostałych ocenianych wskaźników nie różniły się istotnie statystycznie. WNIOSKI Dzieci z niewyrównaną cukrzycą typu 1 charakteryzują się istotnie większą intensywnością występowania próchnicy. Stan przyzębia dzieci z cukrzycą typu 1 nie odbiega natomiast od stanu przyzębia dzieci zdrowych.Congenital adrenal hyperplasia (CAH) occurring in twins is extremely rare. Vps34-IN-1 Most of these cases are of classic salt-wasting CAH due to 21-hydroxylase enzyme deficiency. Only two cases of the simple virilising form of CAH have been reported previously, with variable clinical presentations. In this report, we describe a pair of monozygotic twins with classic simple virilising form of CAH, who had a simultaneous onset and similar severity of clinical manifestations. Genetic analysis of the CYP21A2 gene in twin 1 showed the pres-ence of two heterozygous pathogenic sequence variants, c.518T>A and c.955C>T in the CYP21A2 gene, consistent with a diagnosis of CAH due to 21-hydroxylase deficiency. We also present a brief review of previous cases of twins with CAH.OBJECTIVES We performed this study based on big data from Electronic Medical Records (EMR) of outpatients and inpatients from 52 hospitals in China to investigate the prevalence of hyperuricemia in Chinese adults. METHODS In this retrospective, descriptive study, a total of 3,363,016 subjects from 52 hospitals in 13 provinces and municipalities in China were enrolled. Eligible subjects were 18 years and older performing serum uric acid test between 2014 and 2018. Subjects were divided into the total group (including the subjects from all the clinic departments) and department-amended group (including the subjects from all the departments except endocrinology, orthopedics, and rheumatology and immunology departments). RESULTS The prevalence of hyperuricemia in the department-amended group was lower than that in the total group (23.06% and 23.42% in 2018, respectively; P less then 0.0001). From 2014 to 2017, the prevalence of hyperuricemia increased year by year (18.29%, 20.02%, 20.16% and 23.06%, respectively) in the department-amended group. Besides, the prevalence of hyperuricemia was higher in men than that in women (38.00% and 11.89%, respectively; P less then 0.0001) and higher in southern region than in northern region (25.84% and 9.79%, respectively; P less then 0.0001) in department-amended group in 2018. CONCLUSIONS Projections from our study estimate that about 271 million Chinese adults 18 years and older may have had hyperuricemia in 2018. These findings will be useful for the future researches and healthcare decision.Improvement in diagnostic and therapeutic techniques has led to revision of past guidelines on the management of Acute Pancreatitis (AP), still not uniformely applied on the territory, partly due to the different distribution of resources to the various centers, partly due to the lack of unequivocal conduct in the approach itself. We had tried to outline most important changes emerged from the revision of recent and authoritative guidelines, focusing on what we believe are still critical points and identifying attitudes more equally shared than others. Based also on the experience of our small center, which however manages numerous cases of AP and their complications, we finally proposed a simple decision algorithm, which does not claim to be a codified recommendation, but only a small and concrete suggestion.BACKGROUND Results from the meta-analysis of randomized controlled studies demonstrate that the adjuvant use of probiotics enhances the rate of Helicobacter pylori (Hp) eradication, reducing concomitantly the occurrence of side effects, mainly diarrhea. Bifidobacterium animalis lactis BB12 and Enterococcus faecium L3 are two bacterial strains reported to clinically improve the rate of Hp eradication, reducing concomitantly the occurrence of side effects. METHODS Due to our pragmatic and routine use of these two strains as an adjuvant therapy to antibiotics and proton pump inhibitors (PPIs) during attempted Hp eradication, we have analyzed retrospectively their impact on the outcome. RESULTS Our results, obtained through a highly pragmatic clinical approach, demonstrate that the probiotic add-on therapy before and after the triple or quadruple therapy to eradicate Hp increases eradication rates and reduces side effects. Moreover, even if observed in only a small cohort of patients, the treatment seems to improve the eubiosis of the gut microbial consortium. CONCLUSIONS In conclusion, administration of BB12 and L3 strains as an adjuvant regimen during Hp eradication therapy has better success than conventional therapy (antibiotics plus a PPI) alone.BACKGROUND/AIMS Acute exacerbations of chronic hepatitis B (CHB-AEs) are common in endemic areas and are often presumed to be acute hepatitis B (AHB) due to their similarities in clinical and serological pictures, presenting a major diagnostic dilemma. This study aimed to identify laboratory markers for differentiating between the two groups, and to establish the cut-off value for significant markers.. CONCLUSION A value of 20.5 S/Co of IgM anti-HBc and 1.27 INR could be helpful in differentiating between AHB and CHB-AE. (Clin Mol Hepatol 2020;26187-195).
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