Notes

The Exploitation involving Drug Consumers.
Firms today face rapidly changing and complex environments that managers and leaders must navigate carefully because confronting these changes is directly connected with success and failure in business. In particular, business leaders are adopting a new paradigm of planning, dynamic adaptive plans, which react adaptively to uncertainties by adjusting plans according to rapid changes in circumstances. However, these dynamic plans have been applied in larger-scale industries such as wastewater management in longer-range time frames. This paper follows the dynamic adaptive plan paradigm but transfers it to the technology management context with shorter-range action plans. Based on this new paradigm of risk management and technology planning, we propose a risk-adaptive technology roadmap (TRM) that can adapt to changing complex environments. First we identify risk by topic modeling based on futuristic data and then by sentiment analysis. Second, for the derived risks, we determine new and alternative plans by co-occurrence of risk-related keywords. Third, we convert an existing TRM to network topology with adaptive plans and construct a conditional probability table for the network. Finally, we estimate posterior probability and infer it by Bayesian network by adjusting plans depending on occurrence of risk events. Based on this posterior probability, we remap the paths in the previous TRM to new maps, and we apply our proposed approach to the field of artificial intelligence to validate its feasibility. Our research contributes to the possibility of using dynamic adaptive planning with technology as well as to increase the sustainability of technology roadmapping.The COVID-19 pandemic presented a challenge to the global research community as scientists rushed to find solutions to the devastating crisis. Drawing expectations from resilience theory, this paper explores how the trajectory of and research community around the coronavirus research was affected by the COVID-19 pandemic. Characterizing epistemic clusters and pathways of knowledge through extracting terms featured in articles in early COVID-19 research, combined with evolutionary pathways and statistical analysis, the results reveal that the pandemic disrupted existing lines of coronavirus research to a large degree. While some communities of coronavirus research are similar pre- and during COVID-19, topics themselves change significantly and there is less cohesion amongst early COVID-19 research compared to that before the pandemic. We find that some lines of research revert to basic research pursued almost a decade earlier, whilst others pursue brand new trajectories. The epidemiology topic is the most resilient among the many subjects related to COVID-19 research. Chinese researchers in particular appear to be driving more novel research approaches in the early months of the pandemic. The findings raise questions about whether shifts are advantageous for global scientific progress, and whether the research community will return to the original equilibrium or reorganize into a different knowledge configuration.Bathymetry retrievals from 2D, multispectral imagery, referred to as Satellite-Derived Bathymetry (SDB), afford the potential to obtain global, nearshore bathymetric data in optically clear waters. However, accurate SDB depth retrievals are limited in the absence of "seed depths." The Ice, Cloud, and land Elevation Satellite-2 (ICESat-2) space-based altimeter has proven capable of accurate bathymetry, but methods of employing ICESat-2 bathymetry for SDB retrievals over broad spatial extents are immature. This research aims to establish and test a baseline methodology for generating bathymetric surface models using SDB with ICESat-2. The workflow is operationally efficient (17-37 min processing time) and capable of producing bathymetry of sufficient vertical accuracy for many coastal science applications, with RMSEs of 0.96 and 1.54 m when using Sentinel-2 and Landsat 8, respectively. The highest priorities for further automation have also been identified, supporting the long-range goal of global coral reef habitat change analysis using ICESat-2-aided SDB.Wind-formed features are abundant in Oxia Planum (Mars), the landing site of the 2022 ExoMars mission, which shows geological evidence for a past wet environment. Studies of aeolian bedforms at the landing site were focused on assessing the risk for rover trafficability, however their potential in recording climatic fluctuations has not been explored. Here we show that the landing site experienced multiple climatic changes in the Amazonian, which are recorded by an intriguing set of ridges that we interpret as Periodic Bedrock Ridges (PBRs). Clues for a PBR origin result from ridge regularity, defect terminations, and the presence of preserved megaripples detaching from the PBRs. PBR orientation differs from superimposed transverse aeolian ridges pointing toward a major change in wind regime. Our results provide constrains on PBR formation mechanisms and offer indications on paleo winds that will be crucial for understanding the landing site geology.Many Chemistry-Climate Models (CCMs) include a simplified treatment of brominated very short-lived (VSLBr) species by assuming CH3Br as a surrogate for VSLBr. However, neglecting a comprehensive treatment of VSLBr in CCMs may yield an unrealistic representation of the associated impacts. Here, we use the Community Atmospheric Model with Chemistry (CAM-Chem) CCM to quantify the tropospheric and stratospheric changes between various VSLBr chemical approaches with increasing degrees of complexity (i.e., surrogate, explicit, and full). Our CAM-Chem results highlight the improved accuracy achieved by considering a detailed treatment of VSLBr photochemistry, including sea-salt aerosol dehalogenation and heterogeneous recycling on ice-crystals. selleckchem Differences between the full and surrogate schemes maximize in the lowermost stratosphere and midlatitude free troposphere, resulting in a latitudinally dependent reduction of ∼1-7 DU in total ozone column and a ∼5%-15% decrease of the OH/HO2 ratio. We encourage all CCMs to include a complete chemical treatment of VSLBr in the troposphere and stratosphere.
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