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Mixing In Situ Methods (XRD, Infrared, along with 13C NMR) and also Gas Adsorption Dimensions Reveals CO2-Induced Structural Changes and CO2/CH4 Selectivity for the Accommodating Metal-Organic Platform JUK-8.
OBJECTIVE Upper airway stimulation (UAS) is used to treat patients with moderate to severe obstructive sleep apnea (OSA). The aim of this study is to report the incidence and potential predictors of elevated central and mixed apnea index (CMAI) after UAS. STUDY DESIGN Retrospective chart review of patients undergoing UAS. SETTING Tertiary care center. SUBJECTS AND METHODS Included patients underwent UAS for OSA at our institution between 2014 and 2018. Rapamycin mouse Data collected included demographic information, implantation records, and pre- and postoperative polysomnography (PSG) results. CMAI ≥5 was considered elevated. Post hoc univariate analysis was performed to evaluate factors associated with elevated CMAI. RESULTS In total, 141 patients underwent UAS at our institution. This included 94 men and 47 women with a mean age of 61.2 ± 11.0 years and a mean body mass index of 29.1 ± 3.9 kg/m2. Five patients had an elevated CMAI after surgery during UAS titration. Demographics, comorbid conditions, and device settings were not associated with an elevated postoperative CMAI (P > .05). CONCLUSION The occurrence of an elevated CMAI after surgery may represent treatment-emergent events. Demographics, comorbid conditions, and UAS device settings were not associated with central and mixed apneic events. LEVEL OF EVIDENCE 4.Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer that is unresponsive to chemotherapy; therefore, understanding the causes of chemotherapy resistance is important. The cancer stem cell theory postulates that cancer stem cells (CSCs) are the source of tumor chemoresistance. We enrich laryngeal CSCs to overcome chemoresistance of LSCC. A laryngeal cancer xenograft model was established, and a low dose of cisplatin was administered until chemoresistance arose. A next-generation xenograft model was established using surviving tumor cells, and the test was repeated 4 times to screen for CSCs. Cell-function experiments were performed on each tumor cell generation (m1, m2, m3, and m4). The m3 line, with the highest stemness, was selected for transcriptome sequencing. LY6D was selected for clinical sample validation and functional verification. LY6D expression was detected in 107 laryngeal cancer samples, with high expression in 91 of these samples. LY6D expression was correlated with pathological T- and clinical stages, and with cervical lymph node metastasis. The siLY6D group exhibited reduced adhesion and chemoresistance to cisplatin, 5-fluorouracil, and paclitaxel. LY6D is upregulated in laryngeal cancer and may serve as a biomarker for chemoresistance in CSCs. Moreover, LY6D could serve as an alternative antigenic peptide in the targeted treatment of laryngeal cancer.OBJECTIVE Patients with head and neck cancer (HNC) face a unique set of unmet needs. A subset of these patients experience symptom control challenges related to their disease burden and treatments. A multidisciplinary approach involving palliative medicine is underutilized but crucial to identify and address these concerns. There is limited information on palliative integration with head and neck oncology. STUDY DESIGN Case series with planned data collection. SETTING Academic quaternary care center. SUBJECTS AND METHODS We provide descriptive analyses of patients with HNC, including psychodiagnostic assessment and validated quality-of-life screening, from patients' first encounter at outpatient palliative medicine. RESULTS HNC (N = 80) contributed the greatest number of palliative referrals (25%) between 2010 and 2012. This cohort was 74% male and 79% Caucasian with a mean age of 53 years (95% CI, 51.1-54.9) and with stage IV disease of the oral cavity (28%) or oropharynx (31%). Sixty-three percent of patients had no evidence of disease. Seventy-five percent had a psychological history based on DSM-IV criteria (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), and 70% had a history of substance use disorder. The most distressing quality-of-life concerns were pain, housing and financial problems, and xerostomia. CONCLUSIONS Patients with HNC who were referred to palliative medicine are burdened by multiple physical, psychological, substance use, and social challenges. We recommend comprehensive cancer-specific screening, such as the James Supportive Care Screening, to triage patients to appropriate supportive care services. Palliative care is one of many services that these patients may need, and it should be utilized at any point of the disease trajectory rather than reserved for end-of-life care.Despite a growing body of evidence on the positive impact of sports science for golf, there is still a paucity of research investigating the "perceptions" and "practices" of high-skilled golfers. Professional Golfers' Association Assistant Professionals (future-qualified coaches; n = 430) were surveyed on their "perceptions" and "practices" of "sports science", "warm-ups", "cool-downs" and "strength and conditioning" for golf. Participants perceived the discipline of sports science as beneficial to golfers but lacked implementation in coaching settings. Warm-up protocols were also perceived to be beneficial to all aspects of golf performance; however, the duration of tournament-based (37.84 ± 20.05 min), warm-ups was significantly greater (p less then 0.001) than practice rounds (26.26 ± 18.63 min) and range sessions (13.00 ± 13.38 min). Education continues to be required to raise the understanding of warm-ups for golf. There were mixed perceptions regarding the benefits of a cool-down, with 62.1% of the high-skilled golfers omitting a cool-down following tournament play and practice. Strength and conditioning was perceived as beneficial, with 78.51% engaging in some form of training throughout the year. Results confirm, however, that certain misconceptions around surveyed sports science practices still exist and it is imperative that education disseminates research findings and validated applied practices to coaches and golfers alike.Aim To compare the outcomes of non-invasive break-up time (NI-BUT) test and the other conventional dry eye tests.Methods The right eyes of 170 subjects were included in the study. In order to evaluate the tear quality of the patients, NI-BUT levels were measured by the Scheimplug-Placido disk system (Sirius topography). Tear osmolarity test was performed with TearLab Osmolarity System. Topical anesthesia-assisted type I Schirmer test and topical anesthesia-assisted BUT were lastly applied to all patients in order not to affect other measurements.Results The mean NI-BUT value was 9.59 ± 4.37 sec, tear osmolarity was 292.93 ± 9.30 mOsm/L, Schirmer test was 15.32 ± 6.05 mm/5 min, and biomicroscopic BUT value was 8.98 ± 3.79 sec. The Schirmer test results were statistically significantly correlated with biomicroscopic BUT and NI-BUT values (p = .019, r = 0.180 and p = .030, r = 0.166; respectively). It was also found that tear osmolarity was strongly and inversely correlated with biomicroscopic BUT and topographic NI-BUT values (p less then .
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