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[Predictors associated with vesica guitar neck contracture soon after transurethral process about the prostate].
Gene expression analyses showed that pDC depletion markedly diminished SMG expression of IL-7, BAFF, TNF-α, IFN-γ, CXCL9, CXCL11, CD40, CD40L, Lt-α, Lt-β and NOS2. Hence, pDCs critically contribute to the development and onset of SS-like salivary gland exocrinopathy.Stanford type A aortic dissection (TA-AD) is a life-threatening disease. Most cases of aortic dissection (AD) are sporadic rather than inherited. Unlike that of inherited AD, the pathogenesis of sporadic AD is still unclear. In the current study, we aimed to explore the pathogenesis of sporadic AD through transcriptome sequencing data analyses. We downloaded sporadic TA-AD transcriptome profiles from Gene Expression Omnibus (GEO) and found response to DNA damage stimulus was activated in AD. Furthermore, by conducting mouse AD tissue single cell RNA sequencing and immunostaining, we found that DNA damage mainly occurred in smooth muscle cells (SMCs) and fibroblasts. Next, we examined the repair patterns in response to DNA damage and found the linker molecules RBBP8/NOTCH1 between DNA damage/repair and extracellular matrix (ECM) organization through protein-protein interaction analysis. Thus, we proposed that DNA damage could contribute to AD by regulating ECM changes. To explore the underlying mechanism, we knocked down the DNA repair-related gene RBBP8 in aortic SMCs, which could exacerbate DNA damage, and observed decreased expression level of NOTCH1. Inhibition of NOTCH1 with crenigacestat in vivo accelerated β-aminopropionitrile-induced formation of AD and increased mortality. Meanwhile, phenotype switching of SMCs was induced by Notch1 knockdown or inhibition; this switching occurred via a pathway involving downregulation of contractile marker gene expression and upregulation of MMP2 expression, which might aggravate ECM degradation. In conclusion, excessive DNA damage is a characteristic pathological change of sporadic aortic dissection, which might contribute to ECM changes and AD development via action on the NOTCH1 pathway.Haematococcus pluvialis is traditionally cultivated in a suspension for astaxanthin production. This study presents the novel cultivation approach by immobilized H. pluvialis in bacterial cellulose (BC) produced from the symbiosis of Gluconacetobacter xylinus and H. pluvialis. It was observed that the immobilization itself was a regulator to increase the astaxanthin content. The key genes associated to astaxanthin synthesis, such as psy, lcy, bkt, chy, were significantly up-regulated after immobilization. BC immobilized gel can be utilized concurrently with different technologies to improve astaxanthin accumulation (e.g., amount of induction medium, area of biogel, et al). A small-scale screen panel photobioreactor was design to explore the application of the cultivation approach. Compared to suspended culture, the induction time was shortened from 7 days to 3 days. Astaxanthin productivity of red stage reached 343.2 mg·m-2·d-1. This was greater than that of many other cultivation systems.The status, recent trends and future perspectives in modelling and optimisation of anaerobic co-digestion is investigated. Areas that can be focused on and those which need further research towards enhancing biogas production are pointed out. Co-digestion, modelling and optimisation of anaerobic digestion as well as techno-economic aspects are reviewed in this paper. It was noted that co-digestion requires more research into a variety of bio-resources and their specific blend proportions. Modelling and optimisation of co-digestion with substrate seasonal fluctuations has not been addressed in previous studies. Controlling key process factors including temperature, pH, and carbon to nitrogen ratio is critical in improving biogas yield. Biogas hybridisation is yet to be explored in depth. Rosuvastatin order The majority of researches are focused on mono-digestion, feedstock co-digestion, modelling, and optimisation of anaerobic digestion needs significant further investigations. A multi-objective approach taking all technical and economic parameters in the modelling and optimization is essential.This study investigated the pyrolysis of microalgal-bacterial granular sludge for producing bio-oil and biochar. Results showed that the bio-oil productivity of pyrolyzed MBGS reached 39.5 to 45.4 wt%, while 23.8-41.2% for the nitrogen-containing bio-oil at the temperature of 673 - 1073 K. Meanwhile the biochar with a nitrogen content of 3.7 - 7.0 wt% could also be produced. Moreover, the Van-Krevelen diagram revealed that produced bio-oil had a H/C ratio higher than that from agroforestry biomass, but its O/C ratio was found to be similar those of coal and biochar. It further appeared from a mass conservation analysis that the highest bio-oil production yield was achieved at a pyrolysis temperature of 773 K, while the pyrolytic kinetics of MBGS in the temperature range studied was governed by the 3-D diffusion mechanism with the activation energy of 224.96 kJ·mol-1.Bacterial cellulose (BC) represents a novel bio-origin nonomaterial with its unique properties having diverse applications. Increased market demand and low yield are the major reason for its higher cost. Bacteria belonging to Komagataeibacter sp are the most exploited ones for BC production. Development of a cost-effective bioprocess for higher BC production is desirable. Though static fermentation modes have been majorly employed for BC production using tray fermenters, agitated mode has also been employed successfully with air-lift fermenters as well as stirred tank reactors. Bioprocess advances in recent years has led BC production to an upper level; however, challenges of aeration requirement and labor cost towards the higher end is associated with static cultivation at large scale. We have discussed the bioprocess development for BC production in recent years along with the challenges associated and the path forward.Anaerobic digestion (AD) process is widely considered the most sustainable technology for food waste (FW) disposal due to its advantage of biomethane recovery and beneficial environmental consequences. However, the effects of key components in FW (i.e. starchy food, vegetables, fruits, and meats) on AD process and their methanogenic pathways remain unclear. In this study, the biochemical methane potential (BMP) of cooked rice, cabbage, banana peel, pork and local FW was 288, 283, 254, 630, and 476 NmL CH4/g VSadded, with t80 (time required for 80% methane produced) of 3, 9, 3, 11 and 11 days, respectively. Kinetic analysis suggested diverse hydrolysis rates (0.104-0.679 d-1) and specific methane yields (39-119 NmL CH4/g VSadded/d). The relative abundances of key methanogens in the reactors were diverse, leading to the variation in acetoclastic and hydrogenotrophic methanogenic pathways. This study provides fundamental information for the operation of AD systems with different FW compositions.A series of commercial powdered media (Cell-Hi F2P, JWP and WP) and a hydroponics medium (FloraMicroBloom) were investigated for the cultivation of P. tricornutum, and compared with f/2 (a commonly employed laboratory cultivation medium; costlier to scale). Cell-Hi JWP showed good performance characteristics including cost-effectiveness. Outdoor cultivation of P. tricornutum in an airlift photobioreactor, using Cell-Hi JWP in the United Kingdom (UK) during September and October (average daily temperature ranging between 8 and 18 °C and natural sunlight) was comparable to cultivation indoors under controlled temperature and lighting. A strong positive correlation between fucoxanthin and chlorophyll a content, and a weak inverse correlation between eicosapentaenoic (EPA) content and temperature were observed. Commensal bacterial counts revealed a sinusoidal growth profile with a change in community dominance from Halomonas sp. to Marinobacter sp. This investigation reveals for the first time that a multi-product approach can be adopted with P. tricornutum in a UK outdoor environment using commercially viable powdered media.This study investigated the potential ofCellulosimicrobium funkeifor degrading dimethyl phthalate (DMP) and diethyl phthalate (DEP). Effect of different initial concentrations of phthalates on their biodegradation and growth ofC. funkeiwas examined using shake flasks and a continuous stirred tank reactor (CSTR). Complete degradation of both DMP and DEP was achieved in CSTR, even up to 3000 and 2000 mg/L initial concentrations, respectively. Simultaneous degradation of the phthalates in mixture, i.e. more than 80% and 55% biodegradation efficiency were achieved at 1000 and 2000 mg/L initial concentrations of DMP and DEP, respectively, using the CSTR. Mass balance analysis of the degradation results suggested proficient degradation of DMP and DEP with biomass yield values of 0.64 and 0.712, respectively. The high values of inhibition constant Kiestimated using the Tessier and Edward substrate inhibition models indicated very good tolerance ofC. funkeitoward biodegradation of DMP and DEP.This study proposed a novel and high-efficiency strategy, i.e., freezing followed by low-temperature thermal treatment, to significantly promote short-chain fatty acids (SCFAs) production from waste activated sludge compared to traditional freezing/thawing treatment. The maximal production of SCFAs was 212 mg COD/g VSS with a shortened retention time of five days, and the potentially recovered carbon source, including SCFAs, soluble polysaccharides and proteins, reached 321 mg COD/g VSS, increased by 92.1 and 28.3% compared to sole freezing and thermal treatment. Both the solubilization and hydrolysis steps of WAS were accelerated, and the acid-producing microorganisms, such as Macellibacteroides, Romboutsia and Paraclostridium, were greatly enriched, with a total abundance of 13.9%, which was only 0.54% in control. Interestingly, the methane production was inhibited at a shortened retention time, resulting in SCFAs accumulation, whereas it was increased by 32.0% at a longer sludge retention time, providing a potential solution for energy recovery from WAS.The distribution of biomass pyrolysis products under high pressure have rarely been reported. In this study, the effect of pressure on the product distribution of pine sawdust (PS) pyrolysis was studied. The synergistic effect of the side wall rubber (SWR) and PS was confirmed under pressurized conditions. Calcined bottom ash (CBA) and SWR char (SWRC) were used to enhance the quality of the pressurized co-pyrolysis products. The PS and SWR pyrolysis chars obtained under high pressure conditions exhibited serious melting and cross-linking problem. The CO2 content decreased to 19.96 vol% in co-pyrolysis gas with the CBA/SWRC7/3 catalyst. The water content decreased by 85.71% after the SWRC catalyst in the pressurized co-pyrolysis process. Compared with the concentration of benzene in PS and SWR oil, the concentration of benzene in SWR/PS7/3 oil without catalysts increased by 9.57 times and 0.25 times, respectively.Mixed anaerobic microbial communities are a key component in valorization of waste biomass via anaerobic digestion. Similar microbial communities are important as soil and animal microbiomes and have played a critical role in shaping the planet as it is today. Understanding how individual species within communities interact with others and their environment is important for improving performance and potential applications of an inherently green technology. Here, the challenges associated with making measurements critical to assessing the status of anaerobic microbial communities are considered. How these measurements could be incorporated into control philosophies and augment the potential of anaerobic microbial communities to produce different and higher value products from waste materials are discussed. The benefits and pitfalls of current genetic and molecular approaches to measuring and manipulating anaerobic microbial communities and the challenges which should be addressed to realise the potential of this exciting technology are explored.
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