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Quasi-Free Electron-Mediated Light Sensitization through C5-Halopyrimidines.
With its versatility and simplicity, this microfluidic pumping device offers a promising solution for portable, affordable and reliable fluid manipulation for on-chip applications.
The online version contains supplementary material available at 10.1007/s10404-020-02411-w.
The online version contains supplementary material available at 10.1007/s10404-020-02411-w.Issues of fossil fuel and plastic pollution are shifting public demand toward biopolymer-based textiles. For instance, silk, which has been traditionally used during at least 5 milleniums in China, is re-emerging in research and industry with the development of high-tech spinning methods. Various arthropods, e.g. Guggulsterone E&Z insects and arachnids, produce silky proteinic fiber of unique properties such as resistance, elasticity, stickiness and toughness, that show huge potential for biomaterial applications. Compared to synthetic analogs, silk presents advantages of low density, degradability and versatility. Electrospinning allows the creation of nonwoven mats whose pore size and structure show unprecedented characteristics at the nanometric scale, versus classical weaving methods or modern techniques such as melt blowing. Electrospinning has recently allowed to produce silk scaffolds, with applications in regenerative medicine, drug delivery, depollution and filtration. Here we review silk production by the spinning apparatus of the silkworm Bombyx mori and the spiders Aranea diadematus and Nephila Clavipes. We present the biotechnological procedures to get silk proteins, and the preparation of a spinning dope for electrospinning. We discuss silk's mechanical properties in mats obtained from pure polymer dope and multi-composites. This review highlights the similarity between two very different yarn spinning techniques biological and electrospinning processes.Helicobacter pylori (H. pylori) is a gram-negative spiral bacterium that caused infections in half of the world's population and had been identified as type I carcinogen by the World Health Organization. Compared with antibiotic treatment which could result in drug resistance, the vaccine therapy is becoming a promising immunotherapy option against H. pylori. Further, the multi-epitope vaccine could provoke a wider immune protection to control H. pylori infection. In this study, the in-silico immunogenicity calculations on 381 protein sequences of H. pylori were performed, and the immunogenicity of selected proteins with top-ranked score were tested. The B cell epitopes and T cell epitopes from three well performed proteins UreB, PLA1, and Omp6 were assembled into six constructs of multi-epitope vaccines with random orders. In order to select the optimal constructs, the stability of the vaccine structure and the exposure of B cell epitopes on the vaccine surface were evaluated based on structure prediction and solvent accessible surface area analysis. Finally Construct S1 was selected and molecular docking showed that it had the potential of binding TLR2, TLR4, and TLR9 to stimulate strong immune response. In particular, this study provides good suggestions for epitope assembly in the construction of multi-epitope vaccines and it may be helpful to control H. pylori infection in the future.
The online version of this article (10.1007/s10989-020-10148-x) contains supplementary material, which is available to authorized users.
The online version of this article (10.1007/s10989-020-10148-x) contains supplementary material, which is available to authorized users.The purpose of this paper is to describe the impact assessment of a mandatory operational goal-based short-term measure to reduce green house gas (GHG) emissions from ships. The specific measure has been proposed by Denmark and other co-sponsors in the context of the relevant discussion at the International Maritime Organization (IMO) and in particular the so-called Initial IMO Strategy. The IMO is a specialized United Nations agency that regulates shipping. The Initial IMO Strategy, adopted in 2018, has been the most recent major international environmental agreement on how to reduce GHG emissions from ships at a global level. The central research question in this paper is to ascertain the potential impacts of the aforementioned measure to least developed countries (LDCs) and small island developing states (SIDS). There are concerns that such states may be negatively impacted, or even disproportionately negatively impacted, by whatever measure is decided by the IMO. After gaps in the literature and data are identified, our methodology develops a list of potential negative impacts, and looks at a set of factors that may influence these impacts. Then, we discuss how the goal-based measure may impact LDCs/SIDs as regards each of the identified negative impacts. The analysis argues that for LDCs and SIDS a risk for negative and disproportionately negative impacts exists. The only negative impact of which both the probability and the consequence are considered high is the difficulty to finance retrofitting of old ships or investment in new ships. As such, this is likely a disproportionally negative impact. At the same time, the degree of share (or responsibility) of the goal-based measure with respect to such potential negative impacts, vis-à-vis the share of other factors contributing to these impacts, cannot be precisely ascertained, even though we conjecture this share to be low.How much do slums affect women's ability to negotiate access to water, sanitation and hygiene (WaSH)? We used random narratives, interviews, and a review of literature from theoretical and secondary sources to capture the experiences of slum dwellers in South-South Nigeria. Our findings demonstrate that women and girls bear disproportionate burden and risk of poor and inadequate WaSH services in the course of domestic supplies and management and making tough choices in negotiating between personal sanitary needs of privacy and safety as well as attending to domestic hygiene, childcare and other chores. These lived realities and experiences are partly associated with gendered public policy practices, linked to the broader socio-cultural norm that confine women's roles to the private/domestic spheres, while men are free to pursue higher aspirations and opportunities. Limited State capacity to guarantee universal access to WaSH for slum dwellers automatically shifts the responsibility for its provision to the private/domestic domain with women bearing the greater burden.
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