Notes

Tragic intraoperative disappointment of an porcelain femoral head.
Future clinical/research applications are to be expected in this scenario.Morphology and size of the nanoparticles are highly related to the properties; establishing a library to summarize the relationship between the morphology/size and property is very helpful for associated applications. However, the NaYF4 library and thus the correlation between the morphology and property are still absent. Here NaYF4 library is presented and their morphologies and structures are illustrated at atomic scale for the first time. How about the crystal formation affects the morphology is further used to guide the property. Through rational doping, upconversion luminescence, magnetic resonance (MR) and computed tomography are investigated with the nanoprisms, nanoflowers, and nanoplates as models to reveal the effect of the size and morphology. The difference of the properties provides strong evidence on the importance of the library. In particular, the "imperfect structure" of nanoflower is observed on atomic scale and enhances the MR response. The different upconversion intensity ratio for the emissions at 475 and 693 nm is observed from doped NaYF4 with different morphology. Thus, controllable fabrication of NaYF4 with desired morphology is indispensable to achieve the optimal properties as the guidance on how to choose matrix from the library to meet the specific applications.In current orthopedic practice, bone implants used to-date often exhibit poor osteointegration, impaired osteogenesis, and, eventually, implant failure. Actively pursued strategies for tissue engineering could overcome these shortcomings by developing new hybrid materials with bioinspired structure and enhanced regenerative potential. In this study, the osteogenic and therapeutic potential of bioactive vaterite is investigated as a functional component of a fibrous polymeric scaffold for bone regeneration. Hybrid two-layered polycaprolactone scaffolds coated with vaterite (PCL/CaCO3 ) are studied during their 28-days implantation period in a rat femur defect. After this period, the study of tissue formation in the defected area is performed by the histological study of femur cross-sections. Immobilization of alkaline phosphatase (ALP) into PCL/CaCO3 scaffolds accelerates new bone tissue formation and defect repair. PCL/CaCO3 and PCL/CaCO3 /ALP scaffolds reveal 37.3% and 62.9% areas, respectively, filled with newly formed bone tissue in cross-sections compared to unmineralized PCL scaffold (17.5%). Bone turnover markers are monitored on the 7th and 28th days after implantation and reveal an increase of osteocalcin level for both PCL/CaCO3 and PCL/CaCO3 /ALP compared with PCL indicating the activation of osteogenesis. These findings indicate that vaterite, as an osteoconductive component of polymeric scaffolds, promotes osteogenesis, supports angiogenesis, and facilitates bone defect repair.Enabled by active motion of microrobots, conventional biological detection and chemical analyses limited by passive diffusion can be significantly enhanced with fast testing speed and unique sensitiveness. However, controlled release and precise enrichment of microrobot swarms are still difficult to accomplish and thus prohibit them away from practical applications. Here, an efficient and versatile strategy utilizing a needle-shaped hybrid sonoelectrode to disperse and aggregate distinct micromotors is presented, remarkably accelerating mass transfer and enhancing the signal intensity. Hydrogen bubbles generated at the tip of charged electrode can oscillate as actuated by the acoustic field, creating intensified vortexes to disperse micromotors spontaneously. Via removing the attached bubble, the sonoelectrode serving as solid needle isolator is capable of collecting micromotors in a large scale with acoustic streaming in the working reservoir at higher ultrasound frequency. Numerical calculation reveals the streaming profiles with/without microbubbles, and manipulations on classic spherical and tubular micromotor models confirm that the acoustic-powered prototype device is effective for controlling different swarming behaviors in microfluidic channels. Overall, the proposed hybrid sonoelectrode offers a universal and rapid strategy to tailor micromotor swarm behaviors, advancing intelligent microrobots to be featured with active enrichment and compatible for next-generation sensitive portable detection microsystems.As a favorable candidate for the next-generation anode materials, metallic lithium is faced with two crucial problems uncontrollable lithium plating/stripping process and huge volume expansion during cycling. Herein, a 3D lithiophilic skeleton modified with nanoscale Bi sheets (Ni@Bi Foam, i.e., NBF) through one-step facile substitution reaction is constructed. Benefiting from the nanoscale modification, smooth and dense lithiophilic Li3 Bi layer is in situ formed, which improves the uniform deposition of Li subsequently. Meanwhile, the 3D structure inhibits the growth of Li dendrites effectively by reducing local areal current density. Consequently, the NBF exhibits outstanding cycling stability with a high average Coulombic efficiency of 98.46% at 1 mA cm-2 with 1 mAh cm-2 (>500 cycles). Symmetrical cell with NBF exhibits a high reversibility at 1 mA cm-2 with 1 mAh cm-2 (>2000 h). learn more Moreover, superior long-term cycling and rate performance of NBF@Li anode are also acquired when assembled with high areal loading of LiFePO4 (10.1 mg cm-2 ) cathode (Negative/Positive ratio 2.91). Even in anode-free metal lithium batteries, NBF has higher capacity during cycling compared with NF. To conclude, NBF shows excellent electrochemical performance and provides an idea of facile preparation method which can be extend to other metal batteries.
To document the admission systolic blood pressure (SBP), heart rate (HR), and modified Glasgow coma scale (MGCS) score in dogs with and without brain herniation and to determine their relationship with brain herniation.

Retrospective study between 2010 and 2019.

University veterinary teaching hospital.

Fifty-four client-owned dogs with brain herniation and 40 client-owned dogs as a control group, as determined on magnetic resonance imaging.

None.

SBP, HR, MGCS score, and outcome were extracted from medical records. MGCS score was retrospectively calculated based on initial neurological examination in dogs with adequate available information. Dogs with brain herniation had a significantly higher SBP (P=0.0078), greater SBP-HR difference (P=0.0006), and lower MGCS score (P<0.0001) compared to control dogs. A cutoff value of an SBP≥178 mm Hg, SBP-HR≥60, and MGCS score≤14 each provides a specificity of 90%-98%. A combination of an SBP>140 mm Hg and HR<80/min provided 24% sensitivity and 100% specificity to diagnose dogs with brain herniation (P<0.0001).

A high SBP, a greater difference between SBP and HR, a combination of higher SBP and lower HR, and a low MGCS score were associated with brain herniation in dogs presenting with neurological signs upon admission. Early recognition of these abnormalities may help veterinarians to suspect brain herniation and determine timely treatment.
A high SBP, a greater difference between SBP and HR, a combination of higher SBP and lower HR, and a low MGCS score were associated with brain herniation in dogs presenting with neurological signs upon admission. Early recognition of these abnormalities may help veterinarians to suspect brain herniation and determine timely treatment.
To address the shortage of emergency veterinarians, the profession is exploring accelerated training pathways. We sought to contribute to the solution by developing the foundation for an open standard, competency-based veterinary emergency training curriculum for use by any program. We also developed a curricular delivery, tracking, and assessment system to demonstrate how the framework can be integrated into training programs. DESIGN Hybrid Delphi method. SETTING Academia and referral practice. ANIMALS None.

None.

An emergency veterinary competency framework was developed by adapting the human Model of the Clinical Practice of Emergency Medicine, which aligns with the Competency-Based Veterinary Education framework, to produce 4 areas of core competency Patient Care, Interpersonal/Communication, Professionalism, and Practice-based Learning/Improvement. A comprehensive list of veterinary emergency skills was generated and organized within the framework utilizing the hybrid Delphi method. An initial survent, and 20 Professionalism skills, as well as 155 case types. The curricular delivery system tracks and assesses case management proficiency and development of knowledge and professional skills using a patient care eLearning program and simulation training environment. CONCLUSIONS The increasing need for emergency veterinarians is a shared industry-wide challenge. To contribute toward a collective solution, we have undergone an evidence-based process to create the foundation for an open standard competency framework composed of a library of skills and cases. We offer this open standard framework to the veterinary profession and hope it continues to grow and evolve as we drive toward developing competency-based training programs that address the shortage of emergency veterinarians.Programmable engineered DNA origami provides infinite possibilities for customizing nanostructures with controllable precision and configurable functionality. Here, a strategy for fabricating an amphiphilic triangular DNA origami with a central nanopore that integrates phase-stabilizing, porous-gated, and affinity-delivering effects is presented. By introducing the DNA origami as a single-component surfactant, the water-in-oil-in-water (W/O/W) emulsion is effectively stabilized with decreased interfacial tension. Microscopic observation validates the attachment of the DNA origami onto the water-in-oil and oil-in-water interfaces. Furthermore, fluorescence studies and molecular docking simulations indicate the binding interactions of DNA origami with arbutin and coumaric acid at docking sites within central nanopores. These central nanopores are functionalized as molecular gates and affinity-based scaffold for the zero-order release of arbutin and coumaric acid at a constant rate regardless of concentration gradient throughout the whole releasing period. In vivo zebrafish results illustrate the advantages of this zero-order release for anti-melanogenesis therapy over direct exposure or Fickian diffusion. The DNA origami-based W/O/W emulsion presents anti-melanogenic effects against UV-B exposure without cardiotoxicity or motor toxicity. These results demonstrate that this non-toxic amphiphilic triangular DNA origami is capable of solely stabilizing the W/O/W emulsion as well as serving as nanopore gates and affinity-based scaffold for constant release.Charge-transfer (CT) complexation between electron-rich and deficient aromatics has been widely applied in functional optical and photovoltaic materials. The selective complexation and spontaneous disassociation behavior of a dynamic charge-transfer coassembly possess potential in designing smart and dynamic luminescent materials, which however have not been addressed so far. In this work, the transient charge-transfer driven coassembly between π-conjugated amino acids and tetracyanobenzene, showing dynamic luminescent transition and circularly polarized luminescence (CPL) evolution property, is illustrated. Transient coassembly behaviors are independent to the diverse binding sites covering fluorene, naphthalene, and anthracene, attributed to the intramolecular CH…π interaction. Incorporation of fluorescent dyes enables a transient light harvesting process with hyperchromic CPL properties. Spontaneous green-to-red CPL transition hydrogels are also fabricated by embedding a competitive CT donor. Using a polymeric matrix treated by organic solvents, charge-transfer coassembly is immobilized with diverse circularly polarized luminescence.
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