Notes

The effects regarding constant PEEP management during surfactant instillation about cerebral hemodynamics inside intubated preterm newborns: any NIRS examine.
Recent advances in high-resolution microscopy have allowed scientists to better understand the underlying brain connectivity. However, due to the limitation that biological specimens can only be imaged at a single timepoint, studying changes to neural projections over time is limited to observations gathered using population analysis. In this paper, we introduce NeuRegenerate, a novel end-to-end framework for the prediction and visualization of changes in neural fiber morphology within a subject across specified age-timepoints. To predict projections, we present neuReGANerator, a deep-learning network based on cycle-consistent generative adversarial network that translates features of neuronal structures across age-timepoints for large brain microscopy volumes. We improve the reconstruction quality of the predicted neuronal structures by implementing a density multiplier and a new loss function, called the hallucination loss. Moreover, to alleviate artifacts that occur due to tiling of large input volumes, we introduce a spatial-consistency module in the training pipeline of neuReGANerator. Finally, to visualize the change in projections, predicted using neuReGANerator, NeuRegenerate offers two modes (i) neuroCompare to simultaneously visualize the difference in the structures of the neuronal projections, from two age domains (using structural view and bounded view), and (ii) neuroMorph, a vesselness-based morphing technique to interactively visualize the transformation of the structures from one age-timepoint to the other. Our framework is designed specifically for volumes acquired using wide-field microscopy. We demonstrate our framework by visualizing the structural changes within the cholinergic system of the mouse brain between a young and old specimen.Computer-Generated Holography (CGH) algorithms simulate numerical diffraction, being applied in particular for holographic display technology. Due to the wave-based nature of diffraction, CGH is highly computationally intensive, making it especially challenging for driving high-resolution displays in real-time. To this end, we propose a technique for efficiently calculating holograms of 3D line segments. We express the solutions analytically and devise an efficiently computable approximation suitable for massively parallel computing architectures. The algorithms are implemented on a GPU (with CUDA), and we obtain a 70-fold speedup over the reference point-wise algorithm with almost imperceptible quality loss. We report real-time frame rates for CGH of complex 3D line-drawn objects, and validate the algorithm in both a simulation environment as well as on a holographic display setup.Segmenting complex 3D geometry is a challenging task due to rich structural details and complex appearance variations of target object. Shape representation and foreground-background delineation are two of the core components of segmentation. selleck kinase inhibitor Explicit shape models, such as mesh based representations, suffer from poor handling of topological changes. On the other hand, implicit shape models, such as level-set based representations, have limited capacity for interactive manipulation. Fully automatic segmentation for separating foreground objects from background generally utilizes non-interoperable machine learning methods, which heavily rely on the off-line training dataset and are limited to the discrimination power of the chosen model. To address these issues, we propose a novel semi-implicit representation method, namely Non-Uniform Implicit B-spline Surface (NU-IBS), which adaptively distributes parametrically blended patches according to geometrical complexity. Then, a two-stage cascade classifier is introduced to carry out efficient foreground and background delineation, where a simplistic Naïve-Bayesian model is trained for fast background elimination, followed by a stronger pseudo-3D Convolutional Neural Network (CNN) multi-scale classifier to precisely identify the foreground objects. A localized interactive and adaptive segmentation scheme is incorporated to boost the delineation accuracy by utilizing the information iteratively gained from user intervention. The segmentation result is obtained via deforming an NU-IBS according to the probabilistic interpretation of delineated regions, which also imposes a homogeneity constrain for individual segments. The proposed method is evaluated on a 3D cardiovascular Computed Tomography Angiography (CTA) image dataset and Brain Tumor Image Segmentation Benchmark 2015 (BraTS2015) 3D Magnetic Resonance Imaging (MRI) dataset.Accurate coronary lumen segmentation on coronary-computed tomography angiography (CCTA) images is crucial for quantification of coronary stenosis and the subsequent computation of fractional flow reserve. Many factors including difficulty in labeling coronary lumens, various morphologies in stenotic lesions, thin structures and small volume ratio with respect to the imaging field complicate the task. In this work, we fused the continuity topological information of centerlines which are easily accessible, and proposed a novel weakly supervised model, Examinee-Examiner Network (EE-Net), to overcome the challenges in automatic coronary lumen segmentation. First, the EE-Net was proposed to address the fracture in segmentation caused by stenoses by combining the semantic features of lumens and the geometric constraints of continuous topology obtained from the centerlines. Then, a Centerline Gaussian Mask Module was proposed to deal with the insensitiveness of the network to the centerlines. Subsequently, a weakly supervised learning strategy, Examinee-Examiner Learning, was proposed to handle the weakly supervised situation with few lumen labels by using our EE-Net to guide and constrain the segmentation with customized prior conditions. Finally, a general network layer, Drop Output Layer, was proposed to adapt to the class imbalance by dropping well-segmented regions and weights the classes dynamically. Extensive experiments on two different data sets demonstrated that our EE-Net has good continuity and generalization ability on coronary lumen segmentation task compared with several widely used CNNs such as 3D-UNet. The results revealed our EE-Net with great potential for achieving accurate coronary lumen segmentation in patients with coronary artery disease. Code at http//github.com/qiyaolei/Examinee-Examiner-Network.Radiation exposure in CT imaging leads to increased patient risk. This motivates the pursuit of reduced-dose scanning protocols, in which noise reduction processing is indispensable to warrant clinically acceptable image quality. Convolutional Neural Networks (CNNs) have received significant attention as an alternative for conventional noise reduction and are able to achieve state-of-the art results. However, the internal signal processing in such networks is often unknown, leading to sub-optimal network architectures. The need for better signal preservation and more transparency motivates the use of Wavelet Shrinkage Networks (WSNs), in which the Encoding-Decoding (ED) path is the fixed wavelet frame known as Overcomplete Haar Wavelet Transform (OHWT) and the noise reduction stage is data-driven. In this work, we considerably extend the WSN framework by focusing on three main improvements. First, we simplify the computation of the OHWT that can be easily reproduced. Second, we update the architecture of the shrinkage stage by further incorporating knowledge of conventional wavelet shrinkage methods. Finally, we extensively test its performance and generalization, by comparing it with the RED and FBPConvNet CNNs. Our results show that the proposed architecture achieves similar performance to the reference in terms of MSSIM (0.667, 0.662 and 0.657 for DHSN2, FBPConvNet and RED, respectively) and achieves excellent quality when visualizing patches of clinically important structures. Furthermore, we demonstrate the enhanced generalization and further advantages of the signal flow, by showing two additional potential applications, in which the new DHSN2 is used as regularizer (1) iterative reconstruction and (2) ground-truth free training of the proposed noise reduction architecture. The presented results prove that the tight integration of signal processing and deep learning leads to simpler models with improved generalization.Domain adversarial training has become a prevailing and effective paradigm for unsupervised domain adaptation (UDA). To successfully align the multi-modal data structures across domains, the following works exploit discriminative information in the adversarial training process, e.g., using multiple class-wise discriminators and involving conditional information in the input or output of the domain discriminator. However, these methods either require non-trivial model designs or are inefficient for UDA tasks. In this work, we attempt to address this dilemma by devising simple and compact conditional domain adversarial training methods. We first revisit the simple concatenation conditioning strategy where features are concatenated with output predictions as the input of the discriminator. We find the concatenation strategy suffers from the weak conditioning strength. We further demonstrate that enlarging the norm of concatenated predictions can effectively energize the conditional domain alignment. Thus we improve concatenation conditioning by normalizing the output predictions to have the same norm of features, and term the derived method as Normalized OutpUt coNditioner (NOUN). However, conditioning on raw output predictions for domain alignment, NOUN suffers from inaccurate predictions of the target domain. To this end, we propose to condition the cross-domain feature alignment in the prototype space rather than in the output space. Combining the novel prototype-based conditioning with NOUN, we term the enhanced method as PROtotype-based Normalized OutpUt coNditioner (PRONOUN). Experiments on both object recognition and semantic segmentation show that NOUN can effectively align the multi-modal structures across domains and even outperform state-of-the-art domain adversarial training methods. Together with prototype-based conditioning, PRONOUN further improves the adaptation performance over NOUN on multiple object recognition benchmarks for UDA. Code is available at https//github.com/tim-learn/NOUN.This study aims to investigate the feasibility and potential of sparse random arrays driven by particle swarm optimization (PSO) algorithm to generate multiple-focus patterns and a large scanning range without grating lobes, which extend the scanning range of focused ultrasound in the treatment of brain tumors, opening the blood-brain barrier, and neuromodulation. Operating at 1.1 MHz, a random spherical array with 200 square elements (sparseness 58%) and a sparse random array with 660 square elements (sparseness 41%) driven by PSO, are employed to simulate different focus patterns. With the same radius of curvature and diameter of transducer and element size, the scanning range of the off-axis single focus of a random 200-element array is two times that of an ordinary array using symmetric arrangement. The focal volume of multiple-focus patterns of the random array is 18 times that of the single focus. The single focus of the sparse random array with 660 elements could steer up to ±23 mm in the radial direction, without grating lobes.
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