Notes

Transcriptomic analysis involving tumor tissues along with organoids discloses the family genes regulating the proliferation regarding lung adenocarcinoma.
Recognizing how climate change will impact populations can aid in making decisions about approaches for conservation of endangered species. The blunt-nosed leopard lizard (Gambelia sila) is a federally endangered species that, despite protection, remains in extremely arid, hot areas and may be at risk of extirpation due to climate change. We collected data on the field-active body temperatures, preferred body temperatures and upper thermal tolerance of G. sila. learn more We then described available thermal habitat using biophysical models, which allowed us to (i) describe patterns in lizard body temperatures, microhabitat temperatures and lizard microhabitat use; (ii) quantify the lizards' thermoregulatory accuracy; (iii) calculate the number of hours they are currently thermally restricted in microhabitat use; (iv) project how the number of restricted hours will change in the future as ambient temperatures rise; and (v) assess the importance of giant kangaroo rat burrows and shade-providing shrubs in the current and projected future thermal ecology of G. sila. Lizards maintained fairly consistent daytime body temperatures over the course of the active season, and use of burrows and shrubs increased as the season progressed and ambient temperatures rose. During the hottest part of the year, lizards shuttled among kangaroo rat burrows, shrubs, and open habitat to maintain body temperatures below their upper thermal tolerance, but, occasionally, higher than their preferred body temperature range. Lizards are restricted from staying in the open habitat for 75% of daylight hours and are forced to seek refuge under shrubs or burrows to avoid surpassing their upper thermal threshold. After applying climatic projections of 1 and 2°C increases to 2018 ambient temperatures, G. sila will lose additional hours of activity time that could compound stressors faced by this population, potentially leading to extirpation.Indoor air dynamics and quality in high density residential buildings can be complex as it is affected by both building parameters, pollution sources, and outdoor meteorological conditions. The present study used CONTAM simulations to investigate the intra-building transport and concentration of an inert pollutant continuously emitted from an underground garage of a 15-floor building under moderate Mediterranean weather. The effects of outdoor meteorological conditions (air temperature, wind speed and direction) on indoor distribution of the emitted pollutant was tested under constant conditions. The importance of using actual transient meteorological data and the impact of their temporal resolution on calculated concentrations and exposure levels were also investigated. Vertical profiles of air exchange rate (AER) and CO concentration were shown to be sensitive to indoor-outdoor temperature difference, which controls the extent of the stack effect and its importance relative to wind effect. Even under constant conditions, transient mode simulations revealed that the time needed for pollutant distribution to reach steady state can be quite long (>24h in some cases). The temporal resolution (1h vs. 8h) of the meteorological data input was also found to impact calculated exposure levels, in an extent that varied with time, meteorological conditions and apartment position.In the last two decades, ambient levels of air pollution have declined substantially. At the same time, the Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address the following question is exposure to levels of air pollution below the NAAQS harmful to human health? Furthermore, the contentious nature surrounding environmental regulations urges us to cast this question within a causal inference framework. Several parametric and semi-parametric regression approaches have been used to estimate the exposure-response (ER) curve between long-term exposure to ambient air pollution concentrations and health outcomes. However, most of the existing approaches are not formulated within a formal framework for causal inference, adjust for the same set of potential confounders across all levels of exposure, and do not account for model uncertainty regarding covariate selec monitoring site, while adjusting for a potentially varying set of confounders across the exposure range. Our data set includes rich health, weather, demographic, and pollution information for the years of 2011-2013. The estimated exposure-response curve is increasing indicating that higher ambient concentrations lead to higher cardiovascular hospitalization rates, and ambient PM2.5 was estimated to lead to an increase in cardiovascular hospitalization rates when focusing at the low exposure range. Our results indicate that there is no threshold for the effect of PM2.5 on cardiovascular hospitalizations.
The outbreak of the disease caused by the new coronavirus (COVID-19) has been affecting society's routine and its patterns of interaction worldwide, in addition to the impact on the global economy. To date, there is still no clinically effective treatment for this comorbidity, and drug repositioning might be a good strategy considering the established clinical safety profile. In this context, since COVID-19 affects the respiratory tract, a promising approach would be the pulmonary drug delivery.

Identify repurposing drug candidates for the treatment of COVID-19 based on the data of ongoing clinical trials and in silico studies and also assess their potential to be applied in formulations for pulmonary administration.

A integrative literature review was conducted between June and July 2020, by extracting the results from Clinical Trials, PubMed, Web of Science and Science Direct databases.

By crossing the results obtained from diverse sources, 21 common drugs were found, from which only 4 drugs presented studies of pulmonary release formulations, demonstrating the need for greater investment and incentive in this field.

Even though the lung is a target that facilitates viral infection and replication, formulations for pulmonary delivery of suitable drugs are still lacking for COVID-19 treatment. However, it is indisputable that the pandemic constitutes a concrete demand, with a profound impact on public health, and that, with the appropriate investments, it will give the pharmaceutical industry an opportunity to reinforce the pulmonary delivery field.
Even though the lung is a target that facilitates viral infection and replication, formulations for pulmonary delivery of suitable drugs are still lacking for COVID-19 treatment. However, it is indisputable that the pandemic constitutes a concrete demand, with a profound impact on public health, and that, with the appropriate investments, it will give the pharmaceutical industry an opportunity to reinforce the pulmonary delivery field.
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