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The Effectiveness of your BITSEA being a Tool in order to Earlier Detect Psychosocial Difficulties in Little ones, a Group Randomized Demo.
This article will briefly explain the origin of the diagnosis of lung adenocarcinoma in situ, the adjustment of the new classification catalog, and whether adenocarcinoma in situ is benign or malignant.
.Lung cancer is one of the malignant tumors with the highest morbidity and mortality in the world. see more Immune checkpoint inhibitors (ICIs), including programmed cell death 1 (PD-1) antibody, programmed cell death ligand 1 (PD-L1) antibody, and cytotoxic T lymphocyte associated protein 4 (CTLA-4) antibody. It has brought significant survival benefits to some patients with advanced lung cancer and changed the treatment pattern of advanced lung cancer. Previous studies have shown that the objective response rate of PD-1/PD-L1 antibody in advanced non-small cell lung cancer (NSCLC) is only about 20%. link2 So reliable biomarkers are urgently needed to screen out the potential benefit population of ICIs and improve the clinical response rate. link3 Tumor mutational burden (TMB) is an emerging biomarker of immunotherapy in addition to PD-L1 expression. There is little correlation between PD-L1 expression and TMB in lung cancer. It is estimated that TMB can expand the benefit population of immunotherapy. However, in clinical practice, the detection of TMB, the determination of cut-off value and the clinical guidance strategy are still not standardized. This consensus will give guiding suggestions on the detection and application scenarios of TMB, so as to promote the standardization of TMB application for immunotherapy in lung cancer.
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To evaluate the impact of the covid-19 pandemic on depressive symptoms and suicide risk among patients undergoing treatment in a Public Health Psychosocial Addiction Care Center (CAPS AD III) of Porto Alegre.

Questions retrieved from the Coronavirus Health Impact Survey (CRISIS), translated into Brazilian Portuguese, were used to evaluate the perceptions and behaviors of 70 patients about the covid-19 pandemic. Validated Brazilian versions of PHQ-9 and GAD-7 were used to evaluate the severity of depressive symptoms, suicide risk and anxiety symptoms. A multilogistic regression model was performed to evaluate predictors of suicide risk in the sample.

Around 70% of patients reported moderate depressive symptoms, 30% severe depressive symptoms, 17% of patients reported suicide or death thoughts in more than half of the days and 10% reported it daily. History of alcohol use was identified as the main predictor of suicide risk in the logistic regression model (OR 13.0, p = 0.03).

Individuals with history of alcohol consumption presented with significantly higher suicide risk scores in a psychosocial public health care center in Brazil during covid-19 pandemic. This result can be important to devise better strategies and interventions to support this specific population profile.
Individuals with history of alcohol consumption presented with significantly higher suicide risk scores in a psychosocial public health care center in Brazil during covid-19 pandemic. This result can be important to devise better strategies and interventions to support this specific population profile.
The Cognitive Distortions Questionnaire (CD-Quest) is an instrument that identifies logical errors or cognitive distortions, only available for adults, and used in trial-based cognitive therapy (TBCT).

To develop and validate a version of the CD-Quest for teens (CD-Quest-T) aged 11 to 17 years, and test its psychometric properties.

A total of 299 students participated in the investigation. After having its content validity assessed, the language was adapted to the age group, and the instrument was reduced to 8 items (from the initial 15). Five cognitive therapists analyzed the content and structure of the items. Lastly, to investigate the construct validity of the CD-Quest-T, the instrument was divided into a full scale and two subscales, which measure the frequency of the distortions and the magnitude attributed to them.

The overall internal consistency of the scale was α = 0.77, whereas for the frequency scale, it was α = 0.75, and for the intensity scale, α = 0.73. Results from exploratory factor analysis and concurrent validity indicated that the CD-Quest-T items have good psychometric properties and generate scores reliably.

The psychometric properties of the CD-Quest-T demonstrate its adequacy to measure cognitive distortions in adolescents.
The psychometric properties of the CD-Quest-T demonstrate its adequacy to measure cognitive distortions in adolescents.
Children and adolescents with obesity can now be classified according to metabolic profile, as those with metabolically healthy obesity (MHO) and those with metabolically unhealthy obesity (MUO). We aimed to determine the prevalence of MUO and identify its biochemical predictors in pediatric patients with obesity.

We evaluated the medical records of 187 boys and girls with obesity. The children were divided into MHO and MUO groups, and anthropometric and biochemical parameters were assessed. Oral glucose tolerance test (OGTT) was used to identify impaired glucose regulation and hyperinsulinism, and binary logistic regression analysis was used to determine predictors of MUO in children with obesity.

Of the 187 children, MUO was found in 71.7% (n=134) and MHO in 28.3% (n=53); those in the MHO group were younger than those in the MUO group. Blood pressure, triglyceride, total cholesterol, and uric acid levels were significantly higher in the MUO group than in the MHO group. Further, the MUO group exhibited a significantly higher level of insulin resistance (p<0.05) than the MHO group. Serum levels of uric acid and homeostasis model assessment of insulin resistance index (HOMA-IR) were confirmed as biochemical predictors of the MUO phenotype in children with obesity.

The ratio of MUO in children with obesity was relatively high; further, serum levels of uric acid and HOMA-IR can be used as biochemical predictors of MUO.
The ratio of MUO in children with obesity was relatively high; further, serum levels of uric acid and HOMA-IR can be used as biochemical predictors of MUO.Bombyx mori silk fibers exhibit significant potential for applications in smart textiles, such as fiber sensors, fiber actuators, optical fibers, and energy harvester. Silk fibroin (SF) from B. mori silkworm fibers can be reconstructed/functionalized at the mesoscopic scale during refolding from the solution state into fibers. This facilitates the mesoscopic functionalization by engaging functional seeds in the refolding of unfolded SF molecules. In particular, SF solutions can be self-assembled into regenerated fiber devices by artificial spinning technologies, such as wet spinning, dry spinning, microfluidic spinning, electrospinning, and direct writing. Meso-functionalization manipulates the SF property from the mesoscopic scale, transforming the original silk fibers into smart fiber devices with smart functionalities, such as sensors, actuators, optical fibers, luminous fibers, and energy harvesters. In this review, the progress of mesoscopic structural construction from SF materials to fiber electronics/photonics is comprehensively summarized, along with the spinning technologies and fiber structure characterization methods. The applications, prospects, and challenges of smart silk fibers in textile devices for wearable personalized healthcare, self-propelled exoskeletons, optical and luminous fibers, and sustainable energy harvesters are also discussed.Light-responsive color-switching materials (LCMs) are long-lasting hot fields. However, non-ideal comprehensive performance (such as color contrast and retention time cannot be combined, unsatisfactory repeatability, and non-automated coloring mode) significantly hinder their development toward high-end products. Herein, the development of LCMs that exhibit long retention time, good color contrast, repeatability, and the property of automatic coloring is reported. The realization of this goal stems from the adoption of a bio-inspired multi-component collaborative step-by-step coloring strategy. Under this strategy, a conventional one-step photochromic process is divided into a "light+heat" controlled multi-step process for the fabrication of the desired LCMs. The obtained LCMs can effectively resist the long-troubled ambient-light interference and avoid its inherent yellow background, thereby achieving the longest retention time and good repeatability. Multiple colors are generated and ultra-fast imaging compatible with the laser-printing technology is also realized. The application potential of the materials in short-term reusable identity cards, absorptive readers, billboards, and shelf labels is demonstrated. The results reported herein can potentially help in developing and designing various high-performance, switchable materials that can be used for the production of high-end products.Thrombotic cardio-cerebrovascular diseases seriously threaten human health. Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off-target bleeding risks of most thrombolytic drugs, resulting in unsatisfactory treatment outcomes. Herein, it is proposed that these challenges can be overcome by precisely integrating the conventional thrombolytic strategy with photothermal therapy. After co-assembly engineering optimization, a fibrin-targeting peptide-decorated nanoassembly of DiR (a photothermal probe) and ticagrelor (TGL, an antiplatelet drug) is prepared for thrombus-homing delivery, abbreviated as FT-DT NPs. The elaborately engineered nanoassembly shows multiple advantages, including simple preparation with high drug co-loading capacity, synchronous delivery of two drugs with long systemic circulation, thrombus-targeted accumulation with self-indicating function, as well as photothermal-potentiated thrombus penetration and thrombolysis with high therapeutic efficacy. As expected, FT-DT NPs not only show bright fluorescence signals in the embolized vessels, but also perform photothermal/antiplatelet synergistic thrombolysis in vivo. This study offers a simple and versatile co-delivery nanoplatform for imaging-guided photothermal/antiplatelet dual-modality thrombolysis.The investigation of novel growth mechanisms for electrodes and the understanding of their in situ energy storage mechanisms remains major challenges in rechargeable lithium-ion batteries. Herein, a novel mechanism for the growth of high-purity diversified Li3 VO4 nanostructures (including hollow nanospheres, uniform nanoflowers, dispersed hollow nanocubes, and ultrafine nanowires) has been developed via a microwave irradiation strategy. In situ synchrotron X-ray diffraction and in situ transmission electron microscope observations are applied to gain deep insight into the intermediate Li3+ x VO4 and Li3+ y VO4 phases during the lithiation/delithiation mechanism. The first-principle calculations show that lithium ions migrate into the nanosphere wall rapidly along the (100) plane. Furthermore, the Li3 VO4 hollow nanospheres deliver an outstanding reversible capacity (299.6 mAh g-1 after 100 cycles) and excellent cycling stability (a capacity retention of 99.0% after 500 cycles) at 200 mA g-1 . The unique nanostructure offers a high specific surface area and short diffusion path, leading to fast thermal/kinetic reaction behavior, and preventing undesirable volume expansion during long-term cycling.
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