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This study aimed to improve the accuracy of CT for detection of COVID-19-associated pneumonia and to identify patient subgroups who might benefit most from CT imaging.
A total of 269 patients who underwent CT for suspected COVID-19 were included in this retrospective analysis. COVID-19 was confirmed by reverse-transcription-polymerase-chain-reaction. Basic demographics (age and sex) and initial vital parameters (O
-saturation, respiratory rate, and body temperature) were recorded. Generalized mixed models were used to calculate the accuracy of vital parameters for detection of COVID-19 and to evaluate the diagnostic accuracy of CT. A clinical score based on vital parameters, age, and sex was established to estimate the pretest probability of COVID-19 and used to define low, intermediate, and high risk groups. A p-value of <0.05 was considered statistically significant.
The sole use of vital parameters for the prediction of COVID-19 was inferior to CT. After correction for confounders, such as age and sex, CT showed a sensitivity of 0.86, specificity of 0.78, and positive predictive value of 0.36. In the subgroup analysis based on pretest probability, positive predictive value and sensitivity increased to 0.53 and 0.89 in the high-risk group, while specificity was reduced to 0.68. In the low-risk group, sensitivity and positive predictive value decreased to 0.76 and 0.33 with a specificity of 0.83. The negative predictive value remained high (0.94 and 0.97) in both groups.
The accuracy of CT for the detection of COVID-19 might be increased by selecting patients with a high-pretest probability of COVID-19.
The accuracy of CT for the detection of COVID-19 might be increased by selecting patients with a high-pretest probability of COVID-19.This paper presents the use of a kernel-based machine learning strategy targeting classification and regression tasks in view of automatic flaw(s) detection, localization and characterization. The studied use-case is a structural health monitoring configuration with an array of piezoelectric sensors integrated on aluminium panels affected by flaws of various positions and dimensions. The measured guided wave signals are post processed with a guided wave imaging algorithm in order to obtain an image representing the health of each specimen. These images are then used as inputs to build classification and regression models. In this paper, an extensive numerical validation campaign is conducted to validate the process. PI3K inhibitor Then the inversion is applied to an experimental campaign, which demonstrate the ability to use a numerically-built model to invert experimental data.The Committee on Missing Persons in Cyprus (CMP) is a bicommunal committee established in 1981, tasked to determine the fate of 2002 individuals who went missing during the intercommunal fighting of 1963-64 and the events of 1974. The CMP operates strictly within a humanitarian framework, using a multidisciplinary approach to conclude individual identifications of remains exhumed throughout the island, where all information obtained from different phases of the CMP Project is integrated and assessed in a comprehensive manner. By 2017, although over 1000 sets of remains were recovered and either identified or resolved by the CMP, 137 challenging cases remained unidentified at the CMP Anthropological Laboratory. To resolve these cases, different strategies were adopted where the investigatory component was enhanced through the implementation of new data mining approaches, and the genetic-related data were revised and updated through the adoption of new DNA technologies and the improvement of the Family Reference Samples Database. These new approaches resulted in a dramatic reduction of the number of unidentified cases (by over 70 %) as well as the timeframe required for future identifications. These approaches could serve as an example in other humanitarian contexts facing similar challenges as they can have a profound impact on the families of missing persons.This study investigates the production of nominal compounds (Experiment 1) and simple nouns (Experiment 2) in a picture-word interference (PWI) paradigm to test models of morpho-lexical representation and processing. The continuous electroencephalogram (EEG) was registered and event-related brain potentials [ERPs] were analyzed in addition to picture-naming latencies. Experiment 1 used morphologically and semantically related distractor words to tap into different pre-articulatory planning stages during compound production. Relative to unrelated distractors, naming was speeded when distractors corresponded to morphemes of the compound (sun or flower for the target sunflower), but slowed when distractors were from the same semantic category as the compound (tulip ➔ sunflower). Distractors from the same category as the compound's first constituent (moon ➔ sunflower) had no influence. The diverging effects for semantic and morphological distractors replicate results from earlier studies. ERPs revealed different effects of morphological and semantic distractors with an interesting time course morphological effects had an earlier onset. Comparable to the naming latencies, no ERP effects were obtained for distractors from the same semantic category as the compound's first constituent. Experiment 2 investigated the effectiveness of the latter distractors, presenting them with pictures of the compounds' first constituents (e.g., moon ➔ sun). Interference was confirmed both behaviorally and in the ERPs, showing that the absence of an effect in Experiment 1 was not due to the materials used. Considering current models of speech production, the data are best explained by a cascading flow of activation throughout semantic, lexical and morpho-phonological steps of speech planning.Language is used as a channel by which speakers convey, among other things, newsworthy and informative messages, i.e., content that is otherwise unpredictable to the comprehender. We therefore might expect comprehenders to show a preference for such messages. However, comprehension studies tend to emphasize the opposite i.e., processing ease for situation-predictable content (e.g., chopping carrots with a knife). Comprehenders are known to deploy knowledge about situation plausibility during processing in fine-grained context-sensitive ways. Using self-paced reading, we test whether comprehenders can also deploy this knowledge in favor of newsworthy content to yield informativity-driven effects alongside, or instead of, plausibility-driven effects. We manipulate semantic context (unusual protagonists), syntactic construction (wh- clefts), and the communicative environment (text messages). Reading times (primarily sentence-finally) show facilitation for sentences containing newsworthy content (e.g., chopping carrots with a shovel), where the content is both unpredictable at the situation level because of its atypicality and also unpredictable at the word level because of the large number of atypical elements a speaker could potentially mention.
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