Notes

Neonatal diabetes due to upset pancreatic and also β-cell improvement.
Probability distributions of acoustic signals propagating through the near-ground atmosphere are simulated by the parabolic equation method. The simulations involve propagation at four angles relative to the mean wind, with frequencies of 100, 200, 400, and 800 Hz. The environmental representation includes realistic atmospheric refractive profiles, turbulence, and ground interactions; cases are considered with and without parametric uncertainties in the wind velocity and surface heat flux. The simulated signals are found to span a broad range of scintillation indices, from near zero to exceeding ten. In the absence of uncertainties, the signal power (or intensity) is fit well by a two-parameter gamma distribution, regardless of the frequency and refractive conditions. When the uncertainties are included, three-parameter distributions, namely, the compound gamma or generalized gamma, are needed for a good fit to the simulation data. The compound gamma distribution appears preferable because its parameters have a straight forward interpretation related to the saturation and modulation of the signal by uncertainties.Differences in interaural phase configuration between a target and a masker can lead to substantial binaural unmasking. This effect is decreased for masking noises with an interaural time difference (ITD). Adding a second noise with an opposing ITD in most cases further reduces binaural unmasking. Thus far, modeling of these detection thresholds required both a mechanism for internal ITD compensation and an increased filter bandwidth. An alternative explanation for the reduction is that unmasking is impaired by the lower interaural coherence in off-frequency regions caused by the second masker [Marquardt and McAlpine (2009). J. Acoust. Soc. Am. 126(6), EL177-EL182]. Based on this hypothesis, the current work proposes a quantitative multi-channel model using monaurally derived peripheral filter bandwidths and an across-channel incoherence interference mechanism. This mechanism differs from wider filters since it has no effect when the masker coherence is constant across frequency bands. Combined with a monaural energy discrimination pathway, the model predicts the differences between a single delayed noise and two opposingly delayed noises as well as four other data sets. It helps resolve the inconsistency that simulating some data requires wide filters while others require narrow filters.We computationally investigate a method for spatiotemporally modulating a material's elastic properties, leveraging thermal dependence of elastic moduli, with the goal of inducing nonreciprocal propagation of acoustic waves. Acoustic wave propagation in an aluminum thin film subjected to spatiotemporal boundary heating from one side and constant cooling from the other side was simulated via the finite element method. Material property modulation patterns induced by the asymmetric boundary heating are found to be non-homogenous with depth. Despite these inhomogeneities, it will be shown that such thermoelasticity can still be used to achieve nonreciprocal acoustic wave propagation.Fresnel diffraction is a fundamental wave phenomenon. This article explains its physical nature using the examples of the diffraction of acoustic waves at soft and hard half-planes and at large apertures on a black screen. It is shown that the shadow radiation by opaque screens plays a central role in these diffraction phenomena. Fresnel-Kirchhoff diffraction at large apertures is presented as an asymptotic form of the shadow radiation. Fresnel and Grimaldi-type diffraction at the soft and hard half-planes is revealed as interference of the shadow radiation and the incident wave.A multi-node acoustofluidic chip working on a broadband spectrum and beyond the resonance is designed for cell manipulations. A simple one-dimensional (1D) multi-layer model is used to describe the stationary standing waves generated inside a cavity. The transmissions and reflections of the acoustic wave through the different layers and interfaces lead to the creation of pressure nodes away from the resonance condition. A transparent cavity and a broadband ultrasonic transducer allow the measurement of the acoustic energy over a wide frequency range using particle image velocimetry measurements and the relation between acoustic energy and the particles velocity. The automation of the setup allows the acquisition over a large spectrum with a high frequency definition. The results show a wide continuous operating range for the acoustofluidic chip, which compares well with the 1D model. The variation of the acoustic radiation force when varying the frequency can be compensated to ensure a constant amplitude for the ARF. This approach is finally applied to mesenchymal stem cell (MCS) spheroids cultured in acoustic levitation. The MSC spheroids can be moved and merged just by varying the acoustic frequency. This approach opens the path to various acoustic manipulations and to complex 3D tissue engineering in acoustic levitation.The recently named Rice's whale in the Gulf of Mexico is one of the most endangered whales in the world, and improved knowledge of spatiotemporal occurrence patterns is needed to support their recovery and conservation. Passive acoustic monitoring methods for determining spatiotemporal occurrence patterns require identifying the species' call repertoire. Rice's whale call repertoire remains unvalidated though several potential call types have been identified. This study uses sonobuoys and passive acoustic tagging to validate the source of potential call types and to characterize Rice's whale calls. During concurrent visual and acoustic surveys, acoustic-directed approaches were conducted to obtain visual verifications of sources of localized sounds. Of 28 acoustic-directed approaches, 79% led to sightings of balaenopterid whales, of which 10 could be positively identified to species as Rice's whales. Long-moan calls, downsweep sequences, and tonal-sequences are attributed to Rice's whales based on these matches, while anthropogenic sources are ruled out. A potential new call type, the low-frequency downsweep sequence, is characterized from tagged Rice's whale recordings. The validation and characterization of the Rice's whale call repertoire provides foundational information needed to use passive acoustic monitoring for better understanding and conservation of these critically endangered whales.Three-dimensional (3D) echo decorrelation imaging was investigated for monitoring radiofrequency ablation (RFA) in ex vivo bovine liver. RFA experiments (N = 14) were imaged by 3D ultrasound using a matrix array, with in-phase and quadrature complex echo volumes acquired about every 11 s. Tissue specimens were then frozen at -80 °C, sectioned, and semi-automatically segmented. Receiver operating characteristic (ROC) curves were constructed for assessing ablation prediction performance of 3D echo decorrelation with three potential normalization approaches, as well as 3D integrated backscatter (IBS). ROC analysis indicated that 3D echo decorrelation imaging is potentially a good predictor of local RFA, with the best prediction performance observed for globally normalized decorrelation. Tissue temperatures, recorded by four thermocouples integrated into the RFA probe, showed good correspondence with spatially averaged decorrelation and statistically significant but weak correlation with measured echo decorrelation at the same spatial locations. In tests predicting ablation zones using a weighted K-means clustering approach, echo decorrelation performed better than IBS, with smaller root mean square volume errors and higher Dice coefficients relative to measured ablation zones. These results suggest that 3D echo decorrelation and IBS imaging are capable of real-time monitoring of thermal ablation, with potential application to clinical treatment of liver tumors.The occlusion effect (OE) occurs when the earcanal becomes occluded by an in-ear device, sometimes leading to discomforts experienced by the users due to the augmented perception of physiological noises, or to a distorted perception of one's own voice. read more The OE can be assessed objectively by measuring the amplification of the low-frequency sound pressure level (SPL) in the earcanal using in-ear microphones. However, as revealed by methodological discrepancies found in past studies, the measurement of this objective occlusion effect (OEobj) is not standardized. With the goal of proposing a robust yet simple methodology adapted for field assessment, three experimental aspects are investigated (i) stimulation source and the stimulus's characteristics to induce the phenomenon, (ii) measurement method of the SPL in earcanal, (iii) indicator to quantify the OEobj. To do so, OEobj is measured on human participants in laboratory conditions. Results obtained with a specific insert device suggest using the participant's own voice combined with simultaneous measurements of the SPLs based on the noise reduction method and using a single value indicator leads to a simple yet robust methodology to assess OEobj. Further research is necessary to validate the results with other devices and to generalize the methodology for field assessment.The Reflections series takes a look back on historical articles from The Journal of the Acoustical Society of America that have had a significant impact on the science and practice of acoustics.Currently, there are no approved medicines available for the treatment of hearing loss. However, research over the past two decades has contributed to a growing understanding of the pathological mechanisms in the cochlea that result in hearing difficulties. The concept that a loss of the synapses connecting inner hair cells with the auditory nerve (cochlear synaptopathy) contributes to hearing loss has gained considerable attention. Both animal and human post-mortem studies support the idea that these synapses (ribbon synapses) are highly vulnerable to noise, ototoxicity, and the aging process. Their degeneration has been suggested as an important factor in the speech-in-noise difficulties commonly experienced by those suffering with hearing loss. Neurotrophins such as brain derived neurotrophic factor (BDNF) have the potential to restore these synapses and provide improved hearing function. OTO-413 is a sustained exposure formulation of BDNF suitable for intratympanic administration that in preclinical models has shown the ability to restore ribbon synapses and provide functional hearing benefit. A phase 1/2 clinical trial with OTO-413 has provided initial proof-of-concept for improved speech-in-noise hearing performance in subjects with hearing loss. Key considerations for the design of this clinical study, including aspects of the speech-in-noise assessments, are discussed.The inversion results of geoacoustic parameters using bottom-interacting signals in Jinhae Bay, South Korea, were presented in March 2019 by Kwon, Choi, Ryang, Son, and Jung [J. Acoust. Soc. Am. 145, 1205-1211 (2019)]. At site 1 in this study area, where the surficial sediment was dominated by mud, bottom-loss estimates were typical of losses in sediment with a sound speed lower than that of the water column. In this case, because most of the energy incident on the bottom at the angle of intromission is transmitted into the sediment, scattering may dominate the bottom-path energy, which can lead to an underestimate of bottom loss and an overestimate of the sediment attenuation coefficient. Here, we attempt to provide an accurate estimate of the sediment attenuation coefficient by comparing the difference in amplitudes between the bottom-reflected and sub-bottom-reflected signals over a frequency band of several kHz. To verify the inversion results, measurements of sediment attenuation at the site were also taken by repeatedly transmitting and receiving continuous acoustic waves of 120-180 kHz using four stake transducers embedded in the sediment.
Website: https://www.selleckchem.com/products/pr-619.html