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Distributional outcomes of macroeconomic shock inside real-time: A manuscript method used on your COVID-19 turmoil within Indonesia.
If three individual variables, rather than three principal components, are to be identified that contain most of the information in the whole dataset, one representative for each of the three classes of Corminboeuf et al. is needed one based on partitioning of the density (such as QTAIM), a second based on orbital partitioning (such as NPA), and a third based on the molecular electrostatic potential (such as HLY or CHELPG). © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Partnering across health clinics and community organisations, while worthwhile for improving health and well-being, is challenging and time consuming. Even partnerships that have essential elements for success in place face inevitable challenges. To better understand how cross-organisational partnerships work in practice, this paper examines collaborations between six primary care clinics and community-based organisations in the United States that were part of an initiative to address late-life depression using an enhanced collaborative care model (Archstone Foundation Care Partners Project). As part of an evaluation of the Care Partners Project, 54 key informant interviews and 10 focus groups were conducted from 2015 to 2017. Additionally, more than 80 project-related documents were reviewed. Qualitative thematic analysis was used to code the transcripts and identify prominent themes in the data. Examining clinic and community organisation partnerships in practice highlighted their inherent complexity. The partnerships were fluid and constantly evolving, shaped by a multiplicity of perspectives and values, and vulnerable to unpredictability. Care Partners sites negotiated the complexity of their partnerships drawing upon three main strategies adaptation (allowing for flexibility and rapid change); integration (providing opportunities for multi-level partnerships within and across organisations) and cultivation (fostering a commitment to the partnership and its value). These strategies provided opportunities for Care Partners collaborators to work with the inherent complexity of partnering. Intentionally acknowledging and embracing such complexity rather than trying to reduce or avoid it, may allow clinic and community collaborators to strengthen and sustain their partnerships. © 2020 The Authors. Health and Social Care in the Community published by John Wiley & Sons Ltd.Two of the most prominent challenges faced by people with mental health conditions (MHCs) are experiencing stigma and personal recovery. This study focused on the analysis of baseline data from registrants for integrated arts-based groups in a nationwide psychosocial rehabilitation program in Israel. The aim of the study was to examine the possible associations between self-stigma, personal recovery and creative self-efficacy (CSE) in people with MHCs, and the associations between public stigma, desire for social distance, familiarity with mental illness and CSE in community members. Cross-sectional data were collected by online survey software in October-November 2017 from 114 people with MHCs and 117 community members who enrolled in 15 integrated arts-based groups, and 68 people with MHCs who were not enrolled in integrated groups. The main findings suggest that individuals with MHCs who reported high self-stigma also reported a low sense of personal recovery and low CSE. The CSE of those with MHCs correlated positively with their personal recovery. Among community members, high public stigma was associated with a greater desire for social distance in women, but less contact with MHCs in men. Individuals with MHCs who had previously participated in integrated arts-based groups reported greater personal recovery than those who had not. Community members reported higher CSE and public stigma than the CSE and self-stigma of individuals with MHCs. The findings help characterise both individuals with MHCs and non-clinical community members who decide to enrol in integrated groups, as well as individuals with MHCs who chose not to enrol, enabling similar community-based programs to better identify their conditions and meet their needs. Future research should examine the contribution of integrated arts-based groups to promoting recovery and reducing stigma. © 2020 John Wiley & Sons Ltd.Primary splenic low-grade B-cell lymphoma of the red pulp comprises hairy cell leukemia (HCL) and splenic B-cell lymphoma/leukemia, unclassifiable (SPLL-U). SPLL-U is a rare disease that includes subtypes of a hairy cell leukemia-variant (HCL-v), splenic diffuse red pulp small B-cell lymphoma (SDRPL) and other types that are known as narrow sense SPLL-U (SPLL-U-NS). Notably, limited information is available regarding the BRAF mutation (V600E) and cyclin D3 expression in subtypes of SPLL-U. Therefore, we performed a pathological analysis of the BRAF mutation (V600E) and characterized pathological features of SPLL-U. We reviewed the pathological findings of 12 SPLL-U cases. The 12 cases considered included two cases of HCL-v, six cases of SPLL-U-NS and four undetermined cases. The BRAF mutation (V600E) was detected in three cases, which were all SPLL-U-NS. Cases with the BRAF mutation (V600E) have increased levels of CD103 expression and decreased cyclin D3 and cyclin D1 expression compared with cases that lacked the BRAF mutation. These findings suggest that the BRAF mutation might play a significant role in SPLL-U. Therefore, the significance of the BRAF mutation should be evaluated via genomic or transcriptional analyses of a large cohort of SPLL-U patients. © 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.The asymmetric total synthesis of farnesin, a rearranged ent -kaurenoid, was achieved through a convergent approach. It involves the photo-Nazarov and intramolecular aldol cyclizations to build the syn-syn-syn hydrofluorenol A-B-C ring and bicyclo[3.2.1]octane C-D ring. This is the first application of UV-light induced excited-state Nazarov cyclization of a non-aromatic dicyclicvinyl ketone in a total synthesis. Unlike the conventional acid-promoted ground-state Nazarov reaction, excited-state Nazarov reaction enables stereospecific formation of the highly strained syn-syn-syn fused hydrofluorenone scaffold, via a disrotatory cyclization. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Lactic acid increases the flexibility of the stratum corneum by linking directly to keratin without water. However, another study reported the involvement of water. This study aimed to clarify how lactic acid contributes to the flexibility of the stratum corneum (SC) of the face. MATERIALS AND METHODS A tactile sensor was used to measure the change in shared frequency (Δf) in the cheeks of 88 women of various ages. Amounts of water and lactic acid in the SC were measured during all four seasons, and correlations with Δf evaluated. RESULTS Lactic acid and water levels in the SC were not correlated in any season. In the younger subjects only, the lactic acid content correlated with Δf in spring (when at its highest level in the SC), whereas the water content correlated with Δf in summer and autumn (when the water content was high). CONCLUSIONS The overall lack of correlations between lactic acid and water content across all ages and seasons suggested that each contributes independently to the flexibility of the SC and that lactic acid softens the SC without water. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.BACKGROUND AND OBJECTIVES Young adults with childhood maltreatment (CM) histories are particularly vulnerable to depressive symptoms and alcohol use problems. Research suggests that maltreated youth may misuse alcohol in part to alleviate depressive symptoms. However, many youths with depressive symptoms exercise self-control and abstain from heavy alcohol use. The present study aimed to examine the influence of heart rate variability reactivity (HRV-R), a psychophysiological biomarker of self-regulation, in the indirect link between CM and alcohol-use problems via depressive symptoms among low socioeconomic-status rural young adults. METHODS Two waves of data were collected from a community sample of 225 low socioeconomic-status nonmetropolitan young adults (Mage  = 21.56, 52.9% female). HRV data were obtained with an electrocardiogram during a social stress task. CM was assessed through the Childhood Trauma Questionnaire. Alcohol use problems were measured using the Alcohol Use Disorders Identification Test. RESULTS The indirect effect of CM on alcohol use problems via elevated depressive symptoms was positive and significant (α × β = .159, P  less then  .001). Self-regulation, indicated by high HRV-R (ie, vagal withdrawal), was found to significantly buffer the link between depressive symptoms and alcohol use problems (β = .193, P = .022). DISCUSSION AND CONCLUSIONS Adequate self-regulation capacities can protect maltreated youths from self-medicating alcohol use problems. SCIENTIFIC SIGNIFICANCE This study will advance researchers' understanding of the development of alcohol use problems through unwrapping the risk and protective mechanisms underlying the association between young adults' early life stress and alcohol use behaviors. (Am J Addict 2020;29141-150). © 2020 American Academy of Addiction Psychiatry.Many populations, especially in insects, fluctuate in size, and periods of particularly low population size can have strong effects on genetic variation. Effects of demographic bottlenecks on genetic diversity of single populations are widely documented. Fasiglifam solubility dmso Effects of bottlenecks on genetic structure among multiple interconnected populations are less studied, as are genetic changes across multiple cycles of demographic collapse and recovery. We take advantage of a long-term data set comprising demographic, genetic and movement data from a network of populations of the butterfly, Parnassius smintheus, to examine the effects of fluctuating population size on spatial genetic structure. We build on a previous study that documented increased genetic differentiation and loss of spatial genetic patterns (isolation by distance and by intervening forest cover) after a network-wide bottleneck event. Here, we show that genetic differentiation was reduced again and spatial patterns returned to the system extremely rapidly, within three years (i.e. generations). We also show that a second bottleneck had similar effects to the first, increasing differentiation and erasing spatial patterns. Thus, bottlenecks consistently drive random divergence of allele frequencies among populations in this system, but these effects are rapidly countered by gene flow during demographic recovery. Our results reveal a system in which the relative influence of genetic drift and gene flow continually shift as populations fluctuate in size, leading to cyclic changes in genetic structure. Our results also suggest caution in the interpretation of patterns of spatial genetic structure, and its association with landscape variables, when measured at only a single point in time. © 2020 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2020 European Society For Evolutionary Biology.
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