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18; P = .24]; model 3 OR, 1.13 [95% CI, 0.95-1.34; P = .18]; model 4 OR, 0.90 [95% CI, 0.56-1.45; P = .66]). There was a significant association between rs192879175 and AD among ε3 homozygotes (OR, 0.50; 95% CI, 0.37-0.68; P = 8.30 × 10-6).
The results of this genetic association study suggest that ε2/ε3/ε4 alleles are not the only variants in the APOE region that are associated with AD risk. Additional work with independent data is needed to replicate these results.
The results of this genetic association study suggest that ε2/ε3/ε4 alleles are not the only variants in the APOE region that are associated with AD risk. Additional work with independent data is needed to replicate these results.
Prediction models are widely used in health care as a way of risk stratifying populations for targeted intervention. Most risk stratification has been done using a small number of predictors from insurance claims. check details However, the utility of diverse nonclinical predictors, such as neighborhood socioeconomic contexts, remains unknown.
To assess the value of using neighborhood socioeconomic predictors in the context of 1-year risk prediction for mortality and 6 different health care use outcomes in a large integrated care system.
Diagnostic study using data from all adults age 18 years or older who had Kaiser Foundation Health Plan membership and/or use in the Kaiser Permantente Northern California a multisite, integrated health care delivery system between January 1, 2013, and June 30, 2014. Data were recorded before the index date for each patient to predict their use and mortality in a 1-year post period using a test-train split for model training and evaluation. Analyses were conducted in fall of 2019.
dless of model used.
In 2016, the American Joint Committee on Cancer (AJCC) established criteria to evaluate prediction models for staging. No localized prostate cancer models were endorsed by the Precision Medicine Core committee, and 8th edition staging was based on expert consensus.
To develop and validate a pretreatment clinical prognostic stage group system for nonmetastatic prostate cancer.
This multinational cohort study included 7 centers from the United States, Canada, and Europe, the Shared Equal Access Regional Cancer Hospital (SEARCH) Veterans Affairs Medical Centers collaborative (5 centers), and the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) registry (43 centers) (the STAR-CAP cohort). Patients with cT1-4N0-1M0 prostate adenocarcinoma treated from January 1, 1992, to December 31, 2013 (follow-up completed December 31, 2017). The STAR-CAP cohort was randomly divided into training and validation data sets; statisticians were blinded to the validation data until the model was locked. A e international cohort treated with standard curative treatment options, a proposed AJCC-compliant clinical prognostic stage group system for prostate cancer has been developed. This system may allow consistency of reporting and interpretation of results and clinical trial design.Awareness and knowledge have been identified as essential requirements to successfully combat the global threat which COVID-19 currently poses. Rural communities are particularly at risk because of their low socio-economic status and high illiteracy level. There is currently uncertainty regarding how to effectively raise awareness about the pandemic and educate rural communities about it. In this study, we tested the effectiveness of interpersonal communication in awareness creation and knowledge about COVID-19 among rural communities in a developing country. We tested three hypotheses at 0.05 level of significance. The sample size was made up 470 participants. The questionnaire served as the instrument for data collection. In the analysis of data, both descriptive and inferential statistics were used. The results demonstrate that interpersonal communication is effective in creating awareness about COVID-19 among rural communities. It was also found that interpersonal communication was effective in improving knowledge about the pandemic among rural communications. We explored the implications of these findings on healthcare delivery.Hand washing is effective for the prevention and transmission of pathogens but washing with water only is not effective at reducing contamination. The study focussed on the evaluation of hand washing behaviour in Basic schools (Primary and Junior High Schools) in Ghana. Results of the study revealed that 75% of responding schools have hand washing stands to promote hand washing with soap. Sixty percent of the hand washing facilities were functional at the time of the study in the schools. Hand washing facilities were found to be inadequate as most of the schools lacked running water and soap for hand washing. The school children (72%) were found to have knowledge on hand hygiene. The school children were aware that they can get cholera, typhoid fever, dysentery, diarrhoea, stomach cramps and pains when they do not wash their hands with soap. Majority (68.2%) of school children reported that washing hands after defecation is important but only 17.5% reported actually follow this practice. The school children (51%) reported washing their hands before eating. Many of the schools did not have toilet facilities for the school children. The school children (35%) learnt hand washing from their parents and 60% from the teachers.This study examined media coverage of COVID-19 in Nigeria with attention to the frequency and depth of coverage, story format, news sources, media tone and themes. Four widely read newspapers were content analysed between February 2020 and April 2020. Focus was on Daily Sun, Vanguard, Daily Trust and Leadership. Results indicated that the Nigerian media performed well in terms of covering the pandemic, which in turn created awareness. However, the coverage was not in-depth as most of the reported stories were short and were predominantly straight news. It was also observed that the media cited more of the Nigeria Centre for Disease Control (NCDC) and government officials. Further findings disclosed that most of the stories were alarming and induced panic. Most common topics were coverage of cases in Nigeria, death rates and concerns about Nigeria's preparedness. Public sensitization and education were sparingly covered. Ethics healthcare workers could adhere to received minimal attention. The media should focus more on sensitizing and educating the public on the necessary steps to take in curbing the virus.
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