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The connection among melanin generation as well as lipofuscin creation inside Tyrosinase gene knockout melanocytes employing CRISPR/Cas9 method.
The metal is the one of the most common sensitizing agents worldwide. The morbidity due to this metal represents the allergic contact dermatitis and it is constantly growing in many countries. There are also cases of systemic allergic contact dermatitis, where they could be easily misdiagnosed as adverse drug reactions, which lead to delay of the correct diagnosis and inappropriate treatment. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] remains the cornerstone for prevention of acute stent thrombosis status post PCI. In situations that mandate interruption of DAPT with high risk of stent thrombosis (like our patient), alternative treatment strategies must be considered. The use of cangrelor, with an average half-life of 3-6 minutes as a bridge therapy may provide a viable alternative. However, data regarding its use in non-cardiac surgery patients is almost non-existential. Despite paucity of data, our protocol demonstrates successful off-label use of IV cangrelor bridge therapy in a non-cardiac surgery patient. We present a case of 77-year old male on triple therapy (aspirin, apixaban, and ticagrelor) given history of paroxysmal atrial fibrillation and PCI of in-stent restenosis in an ostial RCA with a drug eluting stent one week prior for NSTEMI who presented with acute GI bleed. Apixaban was held and he was diagnosed with stage I colonic adenocarcinoma with immediate surgical resection recommended. Ticagrelor was discontinued 6 days prior to surgery and Cangrelor was started 24 hours after Ticagrelor discontinuation. Daily P2Y12 assays were performed to ensure adequate platelet inhibition and minimize bleeding risk. Cangrelor was titrated to achieve 65-180 PRUs. Cangrelor was stopped 2 hours before surgical incision and reinitiated 2 hours post-op. Ticagrelor was reinitiated 12 hours post-op once there was surgical confidence of adequate hemostasis. A P2Y12 assay was performed 24 hours after Ticagrelor re-initiation to allay concerns for malabsorption post-op. Patient tolerated exploratory laparoscopic colectomy with minimal bleeding and good post-op recovery. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] The aim of the study was to study the antidiabetic effect of Traganum nudatum in an animal model of diabetes. BACKGROUND Traganum nudatum (T. nudatum) is a medicinal plant widely used in folk medicine by the Moroccan population to treat various diseases including diabetes. OBJECTIVE The objective of the study was to evaluate the antihyperglycemic and hypoglycemic of the aqueous Traganum nudatum exrtcat in normal and streptozotocin-induced diabetic rats. METHODS Normal and streptozotocin-induced diabetic rats were treated orally by the extract of Traganum nudatum (T. nudatum) at a dose of 50 mg/kg. The blood glucose levels were determined during 6 hours and 15 days during this treatment. Besides the oral glucose tolerance and phytochemical tests as well as the analysis of histopathological changes of liver was performed. The antioxidant activity of aqueous T. nudatum extract was also assessed using the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH). RESULTS T. nudatum aerial part aqueous extract (TNAPAE) reduced the blood glucose levels in both normal and diabetic rats. The results demonstrated that TNAPAE treatment exhibited a significant hypoglycemic effect without altering the body weight. In addition, a noticeable influence on glucose tolerance was also remarked after TNAPAE treatment. Moreover, TNAPAE was able to exhibit a beneficial effect on histological structure of liver. Finally a potential antioxidant effect has been shown in vitro. CONCLUSION In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects of T. nudatum in rats supporting then its traditional use for the management of diabetes. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] management and/or treatment requires a comprehensive understanding of the molecular and signaling pathways involved. Recently, much attention has been directed to these molecular and signaling pathways, and it has been suggested that a number of biomolecules/players involved in such pathways, such as PI3K/Akt, NF-κB, STAT, and Nrf2 contribute to the progression, invasion, proliferation, and metastasis of malignant cells. Synthetic anti-tumor agents and chemotherapeutic drugs have been a mainstay in cancer therapy and are widely used to suppress the progression and, hopefully, halt the proliferation of malignant cells. However, these agents have some undesirable side-effects and, therefore, naturally-occurring compounds with high potency and fewer side-effects are now of great interest. Osthole is a plant-derived chemical compound that can inhibit the proliferation of malignant cells and provide potent anti-cancer effects in various tissues. Therefore, in this review, we present the main findings concerning the potential anti-tumor effects of osthole and its derivatives and describe possible molecular mechanisms by which osthole may suppress malignant cell proliferation in different tissues. selleck chemicals llc Copyright© Bentham Science Publishers; For any queries, please email at [email protected] huge amount of medical data is generated every second, and a significant percentage of them are images that need to be analyzed and processed. One of the key challenges in this regard is the recovery of medical images. The medical image recovery procedure should be done automatically by the computers that are the method of identifying object concepts and assigning homologous tags to them. To discover the hidden concepts in the medical images, the low-level characteristics should be used to achieve high-level concepts and that is a challenging task. In any specific case, it requires human involvement to determine the significance of the image. To allow machine-based reasoning on the medical evidence collected, the data must be accompanied by additional interpretive semantics; a change from a pure data-intensive methodology to a model of evidence rich in semantics. In this state-of-art, data tagging methods related to medical images are surveyed which is an important aspect for the recognition of a huge number of medical images.
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