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Hepatic Failure in COVID-19: Is Metal Overburden the Dangerous Result in?
05). After 3 month treatment and follow-ups,the scores of physical, psychological, social and environmental domains were significantly increased than baseline in both groups (P less then 0.05), and the sores of physical, psychological and environmental domains were significantly higher in HPM group than those of control group (P less then 0.05) . CONCLUSION Herb-partitioned moxibustion reduced menstrual pain and improved quality of life, these were sustained for up to 3 months after treatment. Further research is needed to understand long term effect and the mechanism of the intervention.OBJECTIVE To evaluate the treatment effect of acupotomy (Apo) in a rabbit model of knee osteoarthritis (KOA), compare the results of Apo versus electroacupuncture (E-Apu) on ethology, morphology, and structure of the articular cartilage surface in a rabbit model of KOA, and analyze the differences in the treatment effects of Apo versus E-Apu. METHODS Twenty-eight male New Zealand white rabbits were randomized into four groups normal control, blank model, Apo, and E-Apu (n = 7 in each group). Except for the normal control group, the left hindlegs of all rabbits were fixed in an extended position for 5 weeks to establish the KOA model. The passive range of motion (PROM) and Lequesne index were measured before and after the establishment of the KOA model to assess the ethology in all groups. Safranin O-fast green staining and the Mankin score were used to assess the morphological cartilaginous changes to compare the effect of Apo versus E-Apu on the degeneration of articular cartilage, and to identify which therapy was superior in treating KOA. RESULTS Compared with before the establishment of the KOA model, the Lequesne index of the KOA model rabbits was significantly increased (P 0.05). Furthermore, compared with the E-Apu group, the Apo group had a significantly lower Lequesne index (P less then 0.05), and a significantly greater PROM (P less then 0.05). CONCLUSION In a rabbit model of KOA, both Apo and E-Apu reduce disorders of ethology and morphology, and improve the condition of the articular cartilage. The results suggest that Apo is more effective than E-Apu in improving the PROM and alleviating symptoms resulting from cartilage damage in a rabbit model of KOA.OBJECTIVE To investigate the influence of electroacupuncture (EA) on experimentally induced endolymphatic hydrops (EH) in guinea pigs, and elucidate the association between the dehydrating effect of EA and changes in stria vascularis ultrastructure and expression of vasopressin type 2 receptor (V2R), cyclic adenosine monophosphate (cAMP), and aquaporin 2 (AQP2) in the endolymphatic sac (ES). METHODS The EH model was established by intraperitoneal injection of arginine vasopressin (AVP). As a treatment, EA was delivered to Baihui (GV 20) and Tinggong (SI 19) acupoints, once daily for 10 consecutive days. For histomorphological studies, degree of cochlear hydrops was evaluated by hematoxylin-eosin staining, and the ratio of scala media (SM) area to SM + scala vestibuli area was calculated. In mechanical studies, ultrastructural changes in stria vascularis tissue were examined by transmission electron microscopy. In addition, cAMP levels and mRNA expression levels of V2R and AQP2 in the ES were compared among groups. RESULTS EA treatment significantly reduced cochlear hydrops compared with hydropic guinea pigs (P = 0.015). Furthermore, EA attenuated ultrastructural changes in the stria vascularis tissue following EH, significantly upregulated the expression of V2R (P = 0.016), and attenuated AVP-induced upregulation of both cAMP (P = 0.038) and AQP2 expression (P = 0.017) in the ES. CONCLUSION Collectively, the results of the present study suggest that the dehydrating effect of EA is associated with improvement of stria vascularis ultrastructure and V2R-cAMP-AQP2 signaling pathway regulation in the ES.OBJECTIVE To study the meridian tropism (MT) for three Chinese medicines Tinglizi (Semen Lepidii Apetali, TLZ), Yiyiren (Semen Coicis, YYR), Cheqianzi (Semen Plantaginis, CQZ) in vivo experiments. METHODS The extracts of TLZ, YYR, CQZ were orally administered to rats at a dose 234, 700 and 350 mg/kg, respectively. The urinary excretion rate, loss in weight of rats and the electrolyte levels in the plasma were measured, in order to assess the mechanisms of the three traditional Chinese diuretic medicines. RESULTS TLZ, YYR and CQZ exhibited obvious diuretic effect and reduced the weight of saline-loaded animals. All the three diuretic medicines differentially reduced various serum, urinary, lung, stomach, kidney and hormonal markers, thus indicating the different mechanisms of action and a close resemblance with their different meridian as per the MT theory. CONCLUSION Our findings suggest that the three Traditional Chinese Medicine (TCM) medicines-TLZ, YYR and CQZ- possess different Shamisen meridian. This can support the regimen of treating the same disease with different therapies in TCM theory.OBJECTIVE To assess the toxicity of moxa smoke in rats. METHODS Forty-eight female Wister rats were randomly divided into 4 groups (n = 12/group) to simulate moxa smoke exposure in Chinese medicine clinics (CMCs) the control group, and three moxa-smoke exposed groups of PM10 mass concentrations 3-5, 7-9 and 27-30 mg/m3 , respectively. These concentrations were 1 × , 2-3 × , and 7-9 × fold the concentrations found in CMCs. Exposures continued for 12 weeks (200 min/d, 5 d/week). RESULTS No deaths were noted. After the exposure, the body weights, ratios of organ weight to body weight, urinary parameters, hematological parameters, clinical chemistry parameters and microscopic examinations revealed no obvious toxicity. CONCLUSION Moxa smoke did not induce toxic effects in female rats in the study. These findings provide new evidence to the toxicity of moxa smoke.OBJECTIVE To explore the molecular mechanism underpinning the action by investigating its effect on glycogen content and AKT (also known as protein kinase B)/glycogen synthase kinase 3β (GSK- 3β) pathway in the liver of rats with type 2 diabetic induced by high-fat diet. find more METHODS The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injection. Diabetic rats were divided into five groups the model control group, the Metformin group, spleen-kidney supplementing formula groups of low, medium and high doses. Fasting blood glucose (FBG) levels were measured before treatment and every two weeks during treatment. After the treatment, oral glucose tolerance test was performed, and hemoglobin A1c (HbA1c) and C-peptide were measured to assess the formula's effect on glucose metabolism and insulin resistance. The protein expression levels of AKT, GSK-3β and their phosphorylated forms in the liver were also measured to study the formula's role in insulin signaling pathway. RESULTS Spleen-kidney supplementing formula significantly relieved the symptoms of polydipsia, polyuria and weight loss in type 2 diabetic rats, reduced FBG and HbA1c levels, increased glycogen content, and improved insulin sensitivity.
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