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Evaluation of liver organ ailment by non-invasive methods inside perinatally infected B razil teenagers as well as adults managing Human Immunodeficiency Virus (HIV).
Response surface methodology (RSM) and artificial neural network (ANN) were used to generate a model for the optimization of fluoride removal using chemically activated Dalbergia sissoo sawdust (CADS). The single and collective effects of process parameters, i.e., solution pH, CADS dose, initial fluoride concentration, and contact time, were studied. The point of zero charge was found to be 4.2 with zeta potential analysis. In the first phase, a single-parameter study was performed to reveal dependency of fluoride removal on a particular process parameter. Positive effects of increment in CADS dose and contact time and negative effects of solution pH and initial fluoride concentration were observed. The second phase included RSM in which analysis of variance (ANOVA) was applied to test the feasibility of the mathematical model. The F value 1.91, R2 value 0.87, and P value 0.11 show significance of the proposed model. Results obtained from the experiment set for central composite design (CCD) were used to predict the ANN response. Reasonable acceptable values of regression for training, test, and validation (0.76, 0.93, and 0.37) represent the suitability of the model. The ANN predicted 22.1% fluoride removal, which was close to the actual value (20.1%) and was comparable with CCD prediction (25.0%). BET surface area of CADS was found to be 76.33 m2/g. FTIR was performed to recognize the functional groups available for fluoride binding while SEM and EDX were conducted to ensure the changes in adsorbent surface morphology. Regeneration of CADS was feasible using an alkali medium. This study shows that CADS can be used for fluoride removal from aqueous stream in an efficient way.The effect of prenatal bisphenol A (BPA) exposure is increasingly concerned. We investigated the effect of maternal BPA exposure during pregnancy on male offspring and its potential mechanism. Thirty pregnant Sprague Dawley (SD) rats were randomly divided into exposed and control groups. At PND56, the number of sperm, luteinizing hormone, and testosterone in the BPA-exposed group decreased, and testicular tissue structure was damaged in offsprings. At GD20, the miRNA profile in the testis of male offspring was examined and the expression levels of 28 deregulated miRNAs were validated by qRT-PCR. We found that miR-361-5p, miR-203a-3p, and miR-19b-2-5p had significantly different expression levels in the testis. These results suggest that maternal exposure to BPA can lead to differential changes in progeny miRNAs, which will provide direction for future in-depth mechanisms of reproductive injury.Pesticide chlorothalonil is widely applied in tea agroecosystem, potentially disturbing soil microbial-mediated nitrogen cycle. The underlying toxicity mechanism, however, is not well explored. Here, we investigated the long-term effects of chlorothalonil on soil microbial denitrification and N2O emission pattern in a tea field after 40 days of exposure. Results showed that chlorothalonil inhibited denitrification process but remarkably promoted N2O emission by 380-830%. Chlorothalonil significantly inhibited N2O reductase activity but did not affected nosZ abundance. Our results further revealed that chlorothalonil influenced soil denitrification by directly suppressing microbial electron transport system activity, and decreasing electron donor nicotinamide adenine dinucleotide (NADH) and energy source adenosine triphosphate (ATP) levels. Additionally, chlorothalonil also downregulated denitrifying functional genes (narG, nirS, and norB) and declined the relative abundances of potential denitrifiers (i.e., Pseudomonas and Streptomyces). read more Stepwise regression and path modeling suggested that nitrate reductase was the most significant factor in explaining denitrification rate under chlorothalonil applications. This study provides important information for revealing the chronic impacts of pesticide on tea soil denitrification and N2O emission on the basis of electron transport mechanism. Most significantly, N2O emission is underestimated in chlorothalonil-treated soils, which suggests that future estimations of N2O emission from agricultural lands should take account of pesticide dependency conditions.The role of chemical elements in an organism is versatile and multifunctional. However, you should pay attention to the reaction of the organism on the introduction of chemical elements with different biological roles, which is predetermined by the physiological role of organs and body systems. These include the red bone marrow, which primarily responds to endogenous and exogenous factors by its functional significance. Analyzing the myelogram of birds after the various ways of copper NP introduction into the body and the different dosages, we found that, by the end of the experiment, the total numbers of bone marrow cells in all groups were lower than the initial values in the second group-12.54% lower (p  less then  0.05), in third-26.32% lower (p  less then  0.001), for the fourth-14.75% lower (p  less then  0.05), with exception for the first experimental group where this index was 45.51% higher (р  less then  0.001). We revealed the following changes in the peripheral blood the hemoglobin content by the calcium, potassium, magnesium, phosphorus, boron, cobalt, iodine, lithium, sodium, zinc, tin, and strontium in the marrowy aspirate. Moreover, compared with the first group (p  less then  0.01), increasing doses of nanopowders caused a significant rise in the arsenic and tin concentrations and a decline of iodine and strontium. We found that copper nanoparticles ambiguously affect the bone marrow hemopoiesis of poultry; increasing the dose and changing the type of introduction activating the bone marrow hematopoietic function, in particular, granulocyto-, megakaryocyto-, and erythropoiesis.Resident physicians are the first-line health service providers, subjected to prolonged working hours, sleep deprivation and high job demands. Work stress causes reduction in productivity, suboptimal patient care and medical errors. To determine the level of stress among residents and associated factors and stressors. A cross-sectional study at Tanta University Hospitals recruited residents (n = 278), between December 2016 and February 2017. Job stress was assessed using a predesigned questionnaire. The mean age was 26.53 ± 1.35, and 46.4% were males. The majority reported they work more than 48 h/week, do not get a break during work and have a night shift periodically (87%, 83.1% and 94.2%, respectively). Only 4 (1.4%) had low stress while 169 (60.8%) had moderate and 105 (37.8%) had high stress. The study revealed a statistically significant association between high level of stress and being a single resident (p = 0.017), belonging to surgical departments (p = 0.001) and an absence of break during working hours (p = 0.
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