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MCPIP1 Enhances TNF-α-Mediated Apoptosis by way of Downregulation of the NF-κB/cFLIP Axis.
The scattering of an ultrashort laser pulse by an air bubble in water is investigated by means of the Lorenz-Mie theory and the Debye expansion. A 70 fs, 800 nm pulse is considered as a plane wave with a Gaussian temporal envelope. The transient response is treated with the theory derived from Gouesbet and Gréhan [Part. Part. Syst. Charact.17, 213-224 (2000)], taking now into account chromatic dispersion and absorption of water. It is observed that contrary to the case of water droplet in air, the Debye modes p ≥ 1 start their transient scattering at the same time and the same angle (≈90°) and for a large size parameter, they differentiate as time elapses. A parametric study on the size parameter and the spatial extension of the pulse is performed to identify regimes where the different Debye mode are distinguishable in time. Dependence on the scattering angle is also treated. Finally, by considering pulse chirp, it is shown that the laser/bubble distance has an influence on the separability of modes p = 0 and p = 1.To realize ubiquitously used photonic integrated circuits, on-chip nanoscale sources are essential components. Subwavelength nanolasers, especially those based on a metal-clad design, already possess many desirable attributes for an on-chip source such as low thresholds, room-temperature operation and ultra-small footprints accompanied by electromagnetic isolation at pitch sizes down to ∼50 nm. Another valuable characteristic for a source would be control over its emission wavelength and intensity in real-time. Most efforts on tuning/modulation thus far report static changes based on irreversible techniques not suited for high-speed operation. In this study, we demonstrate in-situ dynamical tuning of the emission wavelength of a metallo-dielectric nanolaser at room temperature by applying an external DC electric field. Using an AC electric field, we show that it is also possible to modulate the output intensity of the nanolaser at high speeds. The nanolaser's emission wavelength in the telecom band can be altered by as much as 8.35 nm with a tuning sensitivity of ∼1.01 nm/V. Additionally, the output intensity can be attenuated by up to 89%, a contrast sufficient for digital data communication purposes. Finally, we achieve an intensity modulation speed up to 400 MHz, limited only by the photodetector bandwidth used in this study, which underlines the capability of high-speed operation via this method. This is the first demonstration of a telecom band nanolaser source with dynamic spectral tuning and intensity modulation based on an external E-field to the best of our knowledge.We report on the design, fabrication, and characterization of mass-producible, sensitive, intensity-detection-based planar waveguide sensors for rapid refractive index (RI) sensing; the sensors comprise suspended glass planar waveguides on glass substrates, and are integrated with microfluidic channels. They are facilely and cost-effectively constructed via vacuum-less processes. They yield a high throughput, enabling mass production. see more The sensors respond to solutions with different RIs via variations in the transmitted optical power due to coupling loss in the sensing region, facilitating real-time and simple RI detection. Experiments yield a good resolution of 5.65 × 10-4 RIU. This work has major implications for several RI-sensing-based applications.We use a single-layer thick metallic metasurface to design the 0-,45- and 90-degree polarizers with transmission efficiencies exceeding 95% based on the bright electric dipole resonance and dark magnetic dipole resonance. In addition, we utilize a bilayer metallic metasurface (forming an efficient Fabry-Perot resonator) to propose a circularly polarizing dichroism waveplate (CPDW). The circular polarization dichroism (CPD = IRCP - ILCP.) in the transmission mode at 1.6 µm wavelength reaches 89% and the extinction ratio (ER = IRCP/ILCP) is 8301. These four polarizing elements are integrated to form a full Stokes pixel that almost accurately measures arbitrary polarized light at λ0 = 1.6 µm (including elliptically polarized light).Investigation of photodarkening (PD) in Yb-doped fibers tandem-pumped at 1018 nm is reported. For a homemade Yb-doped aluminosilicate double-clad fiber (YADF), the transmitted power of a 633 nm probe beam is reduced by 2.4% over 2 hours for the tandem pumping configuration at 1018 nm, which is significantly smaller than 33.3% for a laser diode (LD) pumping at 976 nm. A tandem-pumped Yb fiber amplifier also shows a much smaller decrease in the amplified output power over time than a LD-pumped Yb fiber amplifier. Based on fluorescence spectra of the YADF, we can not only associate PD of the YADF to intrinsic oxygen deficiency centers or Tm3+ impurities but also confirm the impact of the excited Yb3+ ion density on PD. The benefits of the tandem pumping in a high-power Yb fiber laser system will be discussed.Supercontinuum (SC) can be generated directly from a random fiber laser (RFL). However, its spectral bandwidth and flatness need to be further optimized for many practical applications. To solve this issue, a RFL based on random distributed Rayleigh scattering in photonic crystal fiber is demonstrated for the first time in this paper. The experimental results revealed that compared with the traditional single or double clad fiber, photonic crystal fiber not only can provide random distributed feedback effectively, but is also a superior nonlinear medium for SC generation which can realize better spectral width and flatness. A flat SC covering 400 nm to 2300 nm is obtained directly from a RFL based on photonic crystal fiber and the corresponding 20 dB bandwidth is more than 1600 nm, which is the widest ever reported to the best of our knowledge. The optical rogue waves caused by solitonic collisions can explain the instability of the output pulses in the time domain. This work proves that photonic crystal fiber can be used in RFL to provide random distributed feedback as well as nonlinear medium for spectrum broadening, and the spectral width and flatness of the generated SC is as good as the conventional method of using a high peak power pulsed laser to pump a piece of photonic crystal fiber, which can greatly reduce the cost of the SC and enrich the research scope of SC as well as RFL.
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