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Plasma televisions greasy acid-binding proteins 7 attention correlates along with depression/anxiety, understanding, and beneficial symptom in patients using schizophrenia.
Combating the menace of plastic waste pollution has become a global environmental challenge. Plastic pollution is capable of affecting land, waterways and oceans as a large percentage of marine and land creatures have died due to the fact that plastic is non-biodegradable and it causes hazards to soil. It also emits toxic gasses when exposed or heated up. It blocks drainage lines and fill up land space causing floods and erosion thereby causing deterioration of the Nigerian roads. Plastics wastes are also harmful to human health; they may contain harmful acids which may lead to death. Nigeria, which is the biggest oil exporting country in Africa, relies mainly on the proceeds of the oil trade for its GDP and based strategy in growing her economy. However, with the declination of oil prices and increase in plastic wastes, the world is tending towards energy and sustainable development. Therefore, an urgent need for recycling plastic wastes into a solution for wealth creation is fundamental in Nigeria. This paper therefore seeks to identify favorable methods for recycling plastic wastes in Nigeria as a tool for solution to diversification and implementation. Evidence based examples are illustrated in the article with viable solution recommended for implementation.Minichromosome maintenance protein 2 (MCM2) is a highly conserved protein from the MCM protein family that plays an important role in eukaryotic DNA replication as well as in cell cycle progression. In addition, it maintains the ploidy level consistency in eukaryotic cells, hence, mutations or alteration of this protein could result in the disintegration of the fine-tuned molecular machinery that can lead to uncontrolled cell proliferation. Moreover, MCM2 has been found to be an important marker for progression and prognosis in different cancers. Therefore, we aimed to analyze the MCM2 expression and the associated outcome in breast cancer (BC) patients based on the publicly available online databases. In this study, server-based gene expression analyses indicate the upregulation of MCM2 (p 2.0) in various BC subtypes as compared to the respective normal tissues. Besides, the evaluation of histological sections from healthy and cancer tissues showed strong staining signals indicating higher expression of MCM2 protein. The overexpression of MCM2 was significantly correlated to promoter methylation and was related to patients' clinical features. Further, mutation analysis suggested missense as the predominant type of mutation (71.4%) with 18 copy-number alterations and 0.2% mutation frequency in the MCM2 gene. This study revealed a significant correlation (Cox p ≤ 0.05) between the higher MCM2 expression and lower patient survival. Finally, we identified the co-expressed genes with gene ontological features and signaling pathways associated in BC development. We believe that this study will provide a basis for MCM2 to be a significant biomarker for human BC prognosis.[This corrects the article DOI 10.1016/j.heliyon.2020.e03900.].Microbial morphology engineering is a novel approach for cell factory to improve the titer of target product in bio-manufacture. Hyaluronic acid (HA), a valuable glycosaminoglycan polymerized by HA synthase (HAS), a membrane protein, is particularly selected as the model product to improve its single-cell HA-producing capacity via morphology engineering. DivIVA and FtsZ, the cell-elongation and cell division related protein, respectively, were both down/up dual regulated in C. glutamicum via weak promoter substitution or plasmid overexpression. Different from the natural short-rod shape, varied morphologies of engineered cells, i.e. small-ellipsoid-like (DivIVA-reduced), bulb-like (DivIVA-enhanced), long-rod (FtsZ-reduced) and dumbbell-like (FtsZ-enhanced), were observed. Applying these morphology-changed cells as hosts for HA production, the reduced expression of both DivIVA and FtsZ seriously inhibited normal cell growth; meanwhile, overexpression of DivIVA didn't show morphology changes, but overexpression of FtsZ surprisingly change the cell-shape into long and thick rod with remarkably enlarged single-cell surface area (more than 5.2-fold-increase). And finally, the single-cell HA-producing capacity of the FtsZ-overexpressed C. glutamicum was immensely improved by 13.5-folds. Flow cytometry analyses verified that the single-cell HAS amount on membrane was enhanced by 2.1 folds. This work is pretty valuable for high titer synthesis of diverse metabolic products with microbial cell factory.Malaria remains the leading cause of infant's mortality in malaria endemic countries like Cameroon. Due to the presence of passively acquired maternal antibodies, malaria in neonates was thought to be scarce. Consequently routine malaria checks are mostly not considered for febrile neonates. Nonetheless findings from malaria endemic areas have proven that malaria in neonates is not uncommon. This study is therefore designed to evaluate malaria among febrile neonates attending the neonatology unit of the Bamenda Regional Hospital. A structured questionnaire and laboratory diagnostic test methods were used for data collection. Maternal sociodemographic data and malaria predisposing factors for neonates with and without malaria were determined using sums and percentages of mean. Regression analysis was used to determine the effects of age of mother, parity, mother's educational level, sex of neonate and malaria predisposing factors on malaria parasitaemia. Chi-square (and Fisher's exact) test was used to calculate sensitivity (%), specificity (%), predictive values (%), likelihood ratios, odd ratios, relative risk and attributable risk. A total of 189 neonates were included in the study out of which 33 (17.46%) tested malaria positive. 54.55% (18/33) of the malaria positive neonates were˃ 3 - 4 weeks old, while only 09.09% (03/33) were within 0 - 1 week of age. Neonates who presented with both signs of "fever + refusal to feed" were found to be most likely (P = 0.0188) to test malaria positive. EIDD-2801 datasheet Based on these findings routine malaria test is recommended especially for all neonates who presents with both signs of "fever + refusal to feed", in malaria endemic regions.
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