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Recent advancements within the breakthrough discovery regarding senolytics.
Radiation dose to the breasts should be kept minimum as breast tissues are highly sensitive to radiation. In mammography, the mean glandular dose (MGD) is used to specify the patient dose. In this study, the MGD during diagnostic mammographic examination was collected using the database from six digital mammography facilities available in the western province in Sri Lanka. The examinations with breast pathology, breast implants, compressed breast thicknesses outside 20-110 mm were excluded in this study. The mean MGD per breast was 3.50 mGy with mean Compressed Breast Thickness (CBT) of 57 mm. The mean MGDs per facility is varying from 1.58 to 2.27 mGy, with overall 75th and 95th percentiles of 2.15 and 2.82 mGy, respectively. The 75th and 95th percentiles MGD per image for the average CBT of 57 ± 12 mm were 2.00 mGy and 2.65 mGy respectively. It is suggested to use the 75th percentile value of average CBT for the western region and it was depending on the specific CBT.To develop a shapable bulk antibacterial nanocomposite biomaterial for bone regeneration. N-Methylphenazonium methosulfate A bulk agarose-gelatine hydrogel was through mineralised using a hydrogel mineralising system aided with electrophoresis, and the mineralised hydrogel was loaded with minocycline to obtain the agarose-gelatine-hydroxyapatite-minocycline nanocomposite. The nanocomposite had a large BET surface area of 44.4518m2/g and a high porosity of 76.9%. Hydroxyapatite crystals were well developed in the hydrogel matrix and exhibited a hybrid structure of microscale and nanoscale motifs. The addition of minocycline resulted in a continuous antibiotic release, inhibiting the growth of Staphylococcus aureus over two weeks in vitro. Exposed to rabbit bone marrow mesenchymal stem cells, the nanocomposite revealed good cytocompatibility in vitro. Furthermore, the biomaterial could effectively enhance the bone regeneration in a critical-size rabbit cranial defect model in vivo. These findings depicted that the nanocomposite, with good biocompatibility and good antibacterial property, is a promising candidate for future clinical application in bone tissue engineering or as a prospective bone replacement biomaterial.How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal study conducted to examine the role of diet and nutrition in promoting cognitive, emotional, and physical health among community-living elderly Singaporeans. The first wave of DaHA, conducted from 2011 to 2017, provided detailed information on diet and baseline cognitive function and health from 1010 community-living elderly in Singapore. Biomarkers of oxidative stress, systemic inflammation, and genetic information were collected. The ongoing second wave of DaHA is conducted from 2017 to 2020, which provides follow- up assessments using established cognitive tests and clinical tools. This well-characterized cohort, with its archived biological samples and high-quality data on diet and lifestyle factors will allow researchers to explore the relationships among diet, nutrition, genes, cognition, mental and physical health in an extremely cost-effective manner. Translations of the research findings into clinical and public health practices will potentially help to promote cognitive health at the population level and reduce healthcare costs related to cognitive impairment.
The authors aimed to develop a moral intervention and to determine whether it was more effective in preventing doping than an educational (i.e.,knowledge-based) intervention; their primary outcome was doping likelihood, and the secondary outcomes were moral identity, moral disengagement, moral atmosphere, and anticipated guilt.

Eligible athletes (N = 303) in the United Kingdom and Greece took part in the study. link2 The authors randomly assigned 33 clubs to either the moral or the educational intervention. They measured outcomes pre- and postintervention and at 3- and 6-month follow-up.

Athletes in both interventions in both countries reported lower doping likelihood and moral disengagement and higher guilt from pre- to postintervention. These effects were maintained at the 3- and 6-month follow-ups. There were no effects on moral identity or moral atmosphere.

In addition to disseminating information about doping, doping prevention programs should include content that focuses on moral variables.
In addition to disseminating information about doping, doping prevention programs should include content that focuses on moral variables.
The aim of this study was to evaluate whether anthropometric and fitness characteristics have changed between former and current elite male and female Austrian young ski racers (U11-U15).

A battery of anthropometric, general, and skiing-specific fitness tests was conducted annually. In total, 1517 participants (846 males, 671 females) who were tested in 2005-2009 ("former athletes" n = 805) and 2015-2019 ("current athletes" n = 712) were included. Independent t tests and Cohen d were calculated to compare the two 5-y periods, separated by sex and age group. The level of significance was set at P < .05.

No significant change in anthropometric characteristics was found over the decade. Current young ski racers performed significantly better in the maximal core flexion strength test in all age categories (ES = 0.88-1.50; P < .02). Core extension strength values were higher in current male U12 and female U12 and U13 athletes (ES = 0.54-0.71; P < .01) and better postural stability values in the lateral direction were found in the age categories U12 and U14 (ES = 0.36-0.68; P < .05), as well as in the forward/backward direction in the age categories U12-U14 (ES = 0.38-1.12; P < .03). Lower-leg extension strength values were apparent in the current U13-U15 age categories (ES = 0.36-1.03; P ≤ .001) and lower drop-jump reactive strength indices in the U13-U15 male athletes (ES = 0.49-0.80; P < .01).

Current and former young ski racers differ significantly in some fitness parameters, which might lead to the assumption that some aspects (such as core strength) have gained more focus in athletic training during the last years compared with 15 y ago.
Current and former young ski racers differ significantly in some fitness parameters, which might lead to the assumption that some aspects (such as core strength) have gained more focus in athletic training during the last years compared with 15 y ago.This study utilized a randomized control trial to examine whether structural changes in the precuneus, insula, caudate, hippocampus, and putamen were related to exercise. A total of 197 healthy older adults with no evidence of dementia participated in moderate-intensity interval training or low-intensity continuous training for 16 weeks. Size decreased in the right hippocampus such that the effect of time was significant but the interaction with condition was not. For the left hippocampus, size decreased in the low-intensity continuous training condition but increased in the moderate-intensity continuous training plus interval training condition at the trend level. Finally, there was a significant time-by-condition interaction such that the thickness of the left insula increased for low-intensity continuous training and decreased for moderate-intensity continuous training plus interval training. Few structural changes were associated with the exercise intervention. Future studies should examine the effects of exercise on brain structure in high-risk or clinical populations for a longer period of time.The authors investigated the effects of unstable strength training (UST) without or with cognitive training (C+UST) on functional performance in community-dwelling older adults. A total of 50 participants were randomly assigned (11) to either 24 weeks of thrice-weekly UST (n = 25) or C+UST (n = 25). All participants performed moderate-intensity strength exercises using unstable surfaces, and C+UST participants simultaneously received cognitive training in addition to UST. Primary outcomes included measures of functional performance single- and dual-task timed up and go tests. Secondary outcomes included dynamic balance, mobility, handgrip strength, flexibility, quality of life, and concern about falling. The authors observed similar improvements on functional performance through the interventions. link3 The C+UST group experienced additional gains at completion (single-task timed up and go -0.90 s, 95% confidence interval [-2.38, -0.03]; dual-task timed up and go -4.80 s, 95% confidence interval [-8.65, -0.95]) compared with the UST group. Moreover, significant differences were observed in mobility (sitting-rising test -1.34, 95% confidence interval [-2.00, -0.20]) at 24 weeks. Both exercise modes improved single-task functional performance, while adding cognitive-training-optimized dual-task functional performance gains.
To examine the efficacy of an the intervention Stand Up Now (SUN) to reduce sedentary behavior (SB) and improve physical function and mobility.

SUN included two groups (a)focused on reducing total SB (SUNSL) and (b)focused on increasing sit-to-stand (STS) transitions (SUNSTS). The participants (N = 71; Mage = 87 ± 7 years) had 12 weekly health coaching sessions. SB, physical function, and mobility were measured at the baseline, 6, and 12 weeks via the activPAL, Short Physical Performance Battery, and the 8-foot up and go, respectively. Linear mixed models examined the outcome variables over time.

Both groups decreased sedentary time (1.3 ± 0.3hr, p < .001), increased standing time (0.5 ± 0.2hr, p < .02), and improved physical function (1.5 ± 0.4 points, p < .001) from the baseline to 6 weeks, and they maintained it at 12 weeks. SUNSTS increased STS transitions (5.4 ± 4.1, p < .001), while SUNSL had no changes (0.5 ± 3.1, p > .9). There were no changes in mobility for either group (0.5 ± 1.5s, p > .05).

SUN demonstrates the efficacy to improve SB and physical function in older adults.
SUN demonstrates the efficacy to improve SB and physical function in older adults.A gap in knowledge exists regarding how to maintain physical activity (PA) for individuals with acquired disabilities following initial introductory experiences. The current study aimed to contribute to filling this gap by exploring the PA pathways of military veterans with a physical disability, particularly those who maintain long-term PA, from impairment to the present. Veterans with a physical disability (N = 18) participated in interviews exploring their PA history and experiences. A reflexive thematic analysis was conducted to generate common pathways in PA participation, as well as to examine which elements of participation supported PA maintenance. Three long-term pathways were identified-two parasport pathways and one recreational PA pathway. Four elements of participation (i.e., mastery, challenge, belongingness, meaning) supported to maintain PA at key junctures. This knowledge provides further understanding of how to promote long-term PA for individuals with acquired disabilities and can support advancements in theory, as well as program development.
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