Notes

Relapsed as well as refractory established Hodgkin lymphoma: could virotherapy help resolve the particular situation?
To describe longitudinal patterns of medication use throughout pregnancy in women with migraine.

We used the IBM MarketScan healthcare claims database in the US to create a cohort of pregnancies enrolled between 2011-2015 resulting in live or stillbirth. Migraine headache was identified based on ICD-9-CM diagnosis codes or procedure codes recorded in clinical encounters. Outcomes were patterns of prescriptions filled for medications that may be used to prevent migraine (antiepileptics, antihypertensives, antidepressants) or treat acute episodes (opioids, triptans, acetaminophen) and of other comorbid conditions (hypertension, psychiatric diagnoses, epilepsy). We used group-based multi-trajectory models to cluster women into similar longitudinal patterns of prescription fills.

Of 859,501 pregnancies, 8168 had migraine. Within migraineurs, before pregnancy, the most commonly filled prescription was for a triptan (43.2%), followed by opioids (26.7%), acetaminophen (26.2%), antidepressants (24.9%), antiepilnd comorbidity during pregnancy highlight an under-studied area relevant for maternal and child health outcomes.
The etiologies of small bowel intussusception (SBI) in adults are varied.

To investigate multidetector computed tomography (MDCT) characteristics in adults with neoplastic and non-neoplastic SBI.

Clinical data and MDCT images diagnosed with SBI in adults from January 2010 to May 2020 were retrospectively reviewed.

The study included a total of 71 patients. Forty-two patients had a combined total of 55 neoplastic intussusceptions, including 29 patients with benign tumors and 13 patients with malignant tumors. Twenty-nine patients had a combined total of 36 non-neoplastic intussusceptions, of which the condition was idiopathic in 23 patients and cased by non-neoplastic benign lesions in six patients. There were no significant differences in patient age or sex ratio in the neoplastic and non-neoplastic groups. In the non-neoplastic group the intussusceptions were shorter in length (3.6 cm vs. 13.2 cm,
<0.05) and smaller in transverse diameter (2.8 cm vs. 4.2 cm,
<0.05), and less likely to be associated with intestinal obstruction (2 vs. 18,
<0.05). The percentage of patients with multiple intussusceptions was greater in the neoplastic group (10/42, 23.8% vs. 4/29, 13.8%). In the non-neoplastic group only one lead point was detected (in a patient with Meckel's diverticulum), whereas lead points were detected in all 55 intussusceptions in the neoplastic group.

There are differences in the clinical and MDCT manifestations of adult neoplastic and non-neoplastic SBIs. Whether a lead point is present or not has implications with regard to deciding on the most appropriate treatment and avoiding unnecessary surgery.
There are differences in the clinical and MDCT manifestations of adult neoplastic and non-neoplastic SBIs. Whether a lead point is present or not has implications with regard to deciding on the most appropriate treatment and avoiding unnecessary surgery.
Differentiation of multiple myeloma (MM) from osteolytic metastatic (OM) bone lesions may be critical in patients with lytic bone lesions but can be challenging for radiologists.

To determine whether computed tomography (CT) can be used to distinguish between MM and other OM bone lesions.

In this retrospective study, 320 lesions of 207 patients diagnosed with MM or OM, based on biopsy or clinical examination, were evaluated. Eight qualitative features were evaluated by two radiologists blinded to the diagnoses. The chi-square and Fisher exact tests, and logistic regression analysis, were used to evaluate the relationships between the CT findings and diagnoses.

High-density areas were more common in OM than MM lesions (85.2% and 19%,
 < 0.001), as were perilesional sclerosis (38.9% vs. Ziprasidone molecular weight 13.2%,
 < 0.001), heterogeneity (on non-contrast CT images, 60% vs. 19.1%,
 < 0.001; on contrast enhanced CT images, 80.6% vs. 28.2%,
 < 0.001), and ill-defined margins (34.6% vs. 9.1%,
 < 0.001). Similarly, OM lesions showed high-density areas more than MM in evaluation of skeletal system subgroups (vertebrae, 93.8% vs. 29.8%,
 < 0.0001; thoracic cage bones, 69.6% vs. 19.2%,
 < 0.001; pelvic bones and sacrum, 84.8% vs. 7.7%,
 < 0.001; peripheral skeletal bones, 81.5% vs. 8.3%,
 < 0.001). Logistic regression analysis revealed that the presence of a high-density area in the lesion increased the probability of a metastasis 25.88-fold (R
 = 0.516,
 < 0.001).

MM and OM lesions can be differentiated by CT; OM lesions exhibit high- density areas.
MM and OM lesions can be differentiated by CT; OM lesions exhibit high- density areas.Boron-rich compounds comprise intricate bonding structures and possess excellent mechanical properties. Here, we report on a comparative study of B13CN and B13C2, which are isostructural but differ in electron fillings, with the former being electron-precise and the latter electron-deficient. Our results show that the different electron fillings in B13CN and B13C2 have profound effects on the bonding features despite their shared crystal structure, generating distinct structural deformation modes and the accompanying stress responses under diverse loading strain conditions. The most striking phenomena include a creeplike stress response under a tensile strain and superior strength under the vast majority of loading conditions for B13CN compared to B13C2. Such enhanced stability of the B12 icosahedra in B13CN by N-induced electron compensation may be effective for structural and mechanical enhancement of other boron-rich compounds and offers improved understanding of a broader class of covalent crystals with complex bonding networks.Reported in this paper is a step economical method toward the general synthesis of 3-vinyl chromones via the reactions between readily available o-hydroxyphenyl enaminones and various alkenes. The domino C-H alkenylation and chromone annulation of the enaminones are involved, which enables the synthesis of 3-vinyl chromone products using both terminal and internal alkenes via a key process of transient C-H halogenation.
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