Notes

GLP-1 Receptor: A New Target for Sepsis.
and at the policy level. Our study shows the importance of multidisciplinary research which includes the voice of local communities.
The development of gene editing technologies is very promising for the treatment of genetic diseases. However, gene editing can be also used to enhance the characteristics of healthy individuals. This study aims to determine ethical challenges that may face the constitution of gene editing in the Middle East and North Africa (MENA) region.

An online discussion forum about the ethical challenges of applying gene editing technologies was held. The participants were a group of researchers (n = 28) from the MENA region.

Most of the participants agreed on the importance of gene editing for the treatment of genetic diseases. However, participants had concerns regarding the use of gene editing to enhance the characteristics of healthy individuals such as athletic abilities and intelligence. Among ethical issues that were raised are justice, harm, beneficence, discrimination, conflict with religion and culture, and lack of regulations.

Several ethical issues were raised for using gene editing technologies based on the perception of biomedical researchers from the MENA region. Therefore, the scientific community and other interested bioethical, social, legal, and governmental parties should be provided with a detailed guide from the scientists in this area for future uses of this technology.
Several ethical issues were raised for using gene editing technologies based on the perception of biomedical researchers from the MENA region. Therefore, the scientific community and other interested bioethical, social, legal, and governmental parties should be provided with a detailed guide from the scientists in this area for future uses of this technology.Seasonal variations affect the rate of biomass accumulation in plants which is internally governed by biochemical metabolites. Studying the impact of atmospheric seasonal changes on biochemical parameters can improve our understanding of various plant species' physiological plasticity. Bamboos are a fast-growing group of woody grass species, widely distributed across tropical and sub-tropical regions of the world, and are an important species of the Indian subcontinent. Nevertheless, limited information is available on the seasonal response of biochemical's in bamboo species growing in ambient atmospheric circumstances. Therefore, we investigated the seasonal biochemical responses of Dendrocalamus strictus clones viz. Pantnagar (PNT) and Dhampur (DHM) to seasonal ambient atmospheric conditions. The concentrations of chlorophyll, protein, carbon, nitrogen, phosphorus, potassium, and magnesium in bamboo leaves were increased significantly (p less then 0.025) in monsoon compared to summer and winter seasons. Carotenoid, total sugar and ascorbic acid contents were highest during winters and reduced significantly during monsoon. Proline content was highest in summer and reduced by 97% during monsoon, indicating effective adaptation to both clones' water-limited conditions. It was inferred that seasonal variation in atmospheric conditions significantly influenced the biochemical constituents of plants. This study provides a biochemical approach for screening potential bamboo species with adaptive nature for plantation purposes intended to mitigate climate change.
The aim of the present study is to develop and validate a reliable and simple application for genotyping serum amyloid A1 (
).

The specific nested PCR was performed to amplify a product of
gene. Two quenching probes (QPs) were designed for detecting two single nucleotide polymorphism (SNP) sites, rs1136743(C/T) and rs1136747(C/T) respectively for
genotypes. Lificiguat The specific nested PCR and QPs of
genotying was introduced into a fully automated genotyping system (I-densy, ARKRAY, Inc.), which enables the genotyping of
from whole blood.

Six genotypes of
(α
, β
, γ
, αβ, αγ and βγ) could be determined by monitoring the fluorescence intensity of two QPs with melting temperature (TM) analysis. Total 121 clinical samples were
genotyped in the fluorescent quenching probes based method with a fully automated I-densy system and were further sequence confirmed with a PCR direct sequencing approach.

This fully automated system is a rapid and reliable strategy for the
genotyping and for its future clinical application.
This fully automated system is a rapid and reliable strategy for the SAA1 genotyping and for its future clinical application.In this work, reduced graphene oxide-nickel (RGO-Ni) nanocomposite is synthesized. X-ray diffraction (XRD), scanning electron microscopy (SEM) and SEM-EDS (Energy Dispersive X-Ray Spectroscopy) are used to study the crystalline nature, morphology and elemental composition of the RGO-Ni nanocomposite, respectively. As synthesized RGO-Ni nanocomposite is used to develop selective adsorptive removal of Rhodamine B (RhB) dye from the aqueous solution. The experiments have been performed to investigate RhB uptake via RGO-Ni nanocomposites which include, contact time (60 min), initial dye concentration (50 mg/100 ml), adsorbent dosage (0.5 mg) and pH 8 of dye solution. The equilibrium concentration is determined by using different models namely, Freundlich, Langmuir and Tempkin. Langmuir isotherm has been fitted well. Langmuir and Tempkin equations are determined to have good agreement with the correlation coefficient data. The kinetic study concluded that RhB dye adsorption follows with the pseudo-second-order kinetic model. Further, adsorption mechanism of RGO-Ni is proposed which involves three steps. The synthesized adsorbent is compared with the other adsorbents in the literature and indicates that RGO-Ni nanocomposite used in this study shown better results for a particular adsorption capacity than polymeric, natural and synthetic bioadsorbents. The regeneration and reusability experiments suggest RGO-Ni nanocomposite can be used for many numbers of times for purification/adsorption.The study investigates the necessity for deregulation of the downstream petroleum sector to tackles shortfalls and to enhance quantities of petroleum commodities in Nigeria. The objective is to boost proficiency in the industry via governance, statutory transformations and vigorous business competition by learning from other advanced countries' skills to transform and fortify the downstream oil industry laws. The study embraces a conceptual legal approach utilising existing literature to aid a doctrinal legal study technique. The research also utilizes primary and secondary founts of legislations, such as, constitutional and case laws. The finding of the research is the absolute authority of the government in the industry and incongruous valuing of oil commodities which made the industry unappealing to financiers to found private refineries that will ensure adequate supply of petroleum and reasonable profits on their investments owing to excessive regulation of the industry by the government. The study designed a model to halt continuous increment in the fuel price and to ensure efficient downstream petroleum industry.
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