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Covid-19: The new reason behind dyspnoea because of decreased bronchi and peripheral muscle mass overall performance.
Activities with the greatest influence on time-average internal dose were showering (-71% for BBzP), cooking (+27% for DEHP), and sleeping (-26% for DEHP). Overall, the results support the hypotheses that (1) transient indoor activities can give rise to intraindividual variability in estimated internal doses of SVOCs, and (2) interindividual variability in such exposure can result from differences in activity patterns and physical human attributes, according to a compound's physical-chemical properties.The Adirondack Mountain region of New York, a historical hotspot for atmospheric sulfur and nitrogen deposition, features abundant lakes that are experiencing browning associated with recovery from acidification. Yet, much remains unknown about the photoreactivity of Adirondack lake waters. We quantified the apparent quantum yields (Φapp,RI) of photochemically produced reactive intermediates (RIs), such as excited triplet states of dissolved organic matter (3DOM*), singlet oxygen (1O2), and hydroxyl radicals (•OH), for surface waters collected from 16 representative Adirondack lakes. Φapp,3DOM* and Φapp,1O2 for native Adirondack lake waters fell within ranges reported for whole waters and DOM isolates from various sources, while Φapp,•OH were substantially lower than those measured for other aquatic samples. Orthogonal partial least squares and multiple linear regression analyses identified the spectral slope coefficient from 290 to 400 nm (S290-400) as the most effective predictor of Φapp,RI among measured water chemistry parameters and bulk DOM properties. Φapp,RI also exhibited divergent responses to controlled pH adjustment and aluminum or iron addition simulating hypothetical scenarios relevant to past and future water chemistry conditions of Adirondack lakes. This study highlights the need for continued research on changes in photoreactivity of acid-impacted aquatic ecosystems in response to browning and subsequent impacts on photochemical processes.Endocrine-disrupting chemicals (EDCs) can interact with nuclear receptors, including estrogen receptor α (ERα) and androgen receptor (AR), to affect the normal endocrine system function, causing severe symptoms. Limited studies queried the EDC mechanisms, focusing on limited chemicals or a set of structurally similar compounds. It remained uncertain how hundreds of diverse EDCs could bind to ERα and AR and cause distinct functional consequences. Here, we employed a series of computational methodologies to investigate the structural features of EDCs that bind to and activate ERα and AR based on more than 4000 compounds. We used molecular docking and molecular dynamics simulations to elucidate the functional consequences and validated structure-function correlations experimentally using a time-resolved fluorescence resonance energy-transfer assay. We found that EDCs share three levels of key fragments. Primary (20 for ERα and 18 for AR) and secondary fragments (38 for ERα and 29 for AR) are responsible for the binding to receptors, and tertiary fragments determine the activity type (agonist, antagonist, or mixed). Selleck BAY-1816032 In summary, our study provides a general mechanism for the EDC function. Discovering the three levels of key fragments may drive fast screening and evaluation of potential EDCs from large sets of commercially used synthetic compounds.Models that characterize life cycle greenhouse gases from electricity generation are limited in their capability to estimate emissions changes at scales that capture the grid-scale benefits of technologies and policies that enhance renewable systems integration. National assumptions about generation mixes are often applied at annual time steps, neglecting spatiotemporal resolutions that provide insights on impacts from time-variable emissions. Our grid-scale model incorporates details of transmission and generation planning that allows a geographically and temporally textured and more realistic assessment of the life cycle greenhouse gas emissions outcomes, using a case study of the Western Interconnection of North America. Results from a co-optimized model of generation, transmission, and operations-the Johns Hopkins Stochastic Multistage Integrated Network Expansion Model-provide a detailed characterization of twenty-one scenarios with different configurations of storage additions, new renewable capacity, and carbon prices. Life cycle results suggest that optimization models that focus on generation alone may underestimate emissions by 18-29% because only emissions from power generation are quantified (i.e., supply chain emissions are omitted) but also that carbon pricing is the predominant driver of reducing emissions in the scenarios we examine. Life cycle assessment of electricity generation should move beyond individual technologies toward capturing the influence of policies at the system level to better understand technology-policy dynamics for the grid.Trifluralin is a widely used dinitroaniline herbicide, which can persist in the environment and has substantial ecotoxicity, especially to aquatic organisms. Trifluralin is very insoluble in water (0.22 mg/L at 20 °C) and highly volatile (vapor pressure of 6.7 mPa at 20 °C); these physicochemical properties determine a large part of its environmental fate, which includes rapid loss from soils if surface-applied, strong binding to soil organic matter, and negligible leaching into water. The trifluralin structure contains a tertiary amino group, two nitro-groups and a trifluoromethyl- group. Despite the strongly xenobiotic character of some of these substituents, biodegradation of trifluralin does occur, and pure cultures of bacteria and fungi capable of partially degrading the molecule either by dealkylation or nitro-group reduction have been identified. There are many unanswered questions about the environmental fate and metabolism of this herbicide; the genes and enzymes responsible for biodegradation are largely unknown, the relative roles of abiotic processes vs growth-linked biodegradation vs cometabolism are unresolved, and the impact of different environmental factors on the rates and extents of biodegradation are not clear. Here, we summarize the relevant literature on the persistence and environmental fate of trifluralin with a focus on biodegradation pathways and mechanisms, and we identify the current major knowledge gaps for future research.
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