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Considering ethnic diversity, SOX8 could not be ruled out as a candidate gene for male infertility. The role of SOX8-mediated Sertoli cell function and BTB integrity played in the pathogenesis of male infertility needs to be further explored in other populations. © 2020 Blackwell Verlag GmbH.We examined the associations between the need for personal control, different types of ingroup commitment, and group-related outcomes (1) defensive responses to ingroup criticism, (2) ingroup disloyalty, and (3) outgroup attitudes. We assumed that collective narcissism (i.e., a belief in ingroup's greatness which is contingent on external validation and stems from frustrated individual needs) should be concerned with defending the ingroup image and derogating outgroups, but not necessarily with being loyal to the ingroup. Secure ingroup identification (i.e., a confidently held ingroup evaluation, which stems from satisfied needs), in contrast, should predict greater ingroup loyalty and positive outgroup attitudes. We expected these effects to be especially strong once we account for the overlap between collective narcissism and group-level self-investment - a key component of ingroup identification. GluR antagonist In a nationally representative sample of Polish adults (n = 1,007), collective narcissism (net of group-level self-investment) mediated between low personal control and ingroup image defense, lower group loyalty, and less positive outgroup attitudes. Secure ingroup identification (group-level self-investment net of collective narcissism) mediated between high personal control and ingroup loyalty and positive outgroup attitudes. It was not associated with ingroup image defense. Implications for understanding the role of identification in inter- and intra-group relations are discussed. © 2020 The British Psychological Society.Hypertension is a common disease worldwide. Alcohol consumption is one of the risk factors for hypertension, however, it is unclear how alcohol consumption elevates blood pressure. Blood pressure could be affected by interactions between genetic variations and alcohol consumption. Thus, we performed a genome-wide interaction study (GWIS) to assess the effect of gene-alcohol consumption interaction on blood pressure among adults aged ≥40 years from the Ansan and Ansung cohort study (n = 6,176), a part of the Korean Genome Epidemiology Study (KoGES). As a result, rs1297184, single-nucleotide polymorphism (SNP) in locus LGR5 was significant (PGWIS = 8.78 × 10-9 ) in GWIS analysis on diastolic blood pressure, but not on systolic blood pressure. However, there was a heteroscedasticity of alcohol consumption. In the GWIS analysis, applying the inverse-variance weighting to correct the systematic inflation slightly attenuated the strength of interaction (PGWIS_IVW = 7.14 × 10-8 ). This interaction was replicated in the Health Examinees cohort (p = .026), a large-scale community-based cohort (n = 18,708). In conclusion, we identified a possible novel interaction between an SNP (rs1297184) and alcohol consumption on blood pressure. © 2020 Wiley Periodicals, Inc.Discoid lupus erythematosus (DLE) of the eyelid is a difficult clinical diagnosis due to its rarity and ability to masquerade as other conditions including blepharoconjunctivitis, allergic contact dermatitis, psoriasis or lichen planus.1 The delay in diagnosis can cause permanent eyelid damage. Less well known is its ability to masquerade histologically as other squamoproliferative conditions, particularly squamous cell carcinoma2,3 . © 2020 British Association of Dermatologists.Mass spectrometry has been the "gold standard" for drugs of abuse (DoA) analysis for many decades because of the selectivity and sensitivity it affords. Recent progress in all aspects of mass spectrometry has seen significant developments in the field of DoA analysis. Mass spectrometry is particularly well suited to address the rapidly proliferating number of very high potency, novel psychoactive substances that are causing an alarming number of fatalities worldwide. This review surveys advancements in the areas of sample preparation, gas and liquid chromatography-mass spectrometry, as well as the rapidly emerging field of ambient ionization mass spectrometry. We have predominantly targeted literature progress over the past ten years and present our outlook for the future. © 2020 Periodicals, Inc. Mass Spec Rev.OBJECTIVES This study aimed to explore whether population characteristics were associated with the use of dental services, individual's personal oral health practices, dental caries and oral health-related impacts using the revised Andersen's behavioural model as the theoretical framework. METHODS This cross-sectional study included participants from a Norwegian general population (N = 1840; 20-79 years) included in the Tromstannen-Oral Health in Northern Norway (TOHNN) study. The variables included in the model were social structure (income, education, urbanization), sense of coherence (SOC), enabling resources (difficulties accessing the dentist, declined treatment, dental anxiety), treatment need, use of dental services, toothbrushing frequency, sugary soda drink consumption, decayed teeth and oral health-related impacts (OHIP-14). Structural equation modelling was used to test the direct and indirect effects within Andersen's behavioural model of access and health outcomes. RESULTS Andersen's behavioural oeconomic inequalities in relation to oral health in the Norwegian population, it is also important to consider how people perceive their own resources (eg financial, psychological, social) as well as their access to dental care in order to support regular dental attendance and potentially, in turn, enhance oral health. © 2020 The Authors. Community Dentistry and Oral Epidemiology published by John Wiley & Sons Ltd.BACKGROUND AND AIM Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) account for a large and growing proportion of liver disease burden globally. The burden of NAFLD/NASH manifests in increasing levels of advanced liver disease and primary liver cancer in Australia. A Markov model was used to forecast NAFLD burden in Australia through 2030. METHODS A model was used to estimate fibrosis progression, primary liver cancer, and liver deaths among the Australian NAFLD population, with changes in incident NAFLD cases based on long-term trends for changes in the prevalence of obesity. Published estimates and surveillance data were applied to build and validate the model projections, including surveillance data for the incidence of liver cancer. RESULTS Prevalent NAFLD cases were projected to increase 25% from the current burden (5 551 000 [4 748 000-6 306 000] cases in 2019) to 7 024 000 [5 838 000-7 886 000] cases in 2030. The projected increase in the number of NASH cases (40%) was greater than that of NAFLD cases.
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