Notes

Construction of the mini-RNA-guided endonuclease CRISPR-Cas12j3.
Results Eighty patients were randomized in the trial. The mean 3-year rates of progression were -1.03 (2.14) dB in the citicoline group and -1.92 (2.23) dB in the placebo group (P=0.07) for 24-2 MD and -0.41 (3.45) dB in the citicoline group and -2.22 (3.63) dB in the placebo group (P=0.02) for 10-2 MD. On average, patients receiving citicoline eyedrops lost 1.86 μm of RNFL in 3 years, versus 2.99 μm in the placebo group (P=0.02). Conclusions Additional treatment with citicoline eyedrops to IOP-lowering treatment might reduce disease progression in patients with progressing glaucoma despite IOP ≤18 mm Hg.Patient satisfaction after modern day cataract surgery requires excellent surgical technique but increasingly demands superior refractive outcomes as well. In many cases, there exists an expectation from patients, as well as surgeons, to achieve emmetropia after cataract surgery. This is particularly true in patients electing premium intraocular lens (IOL) technology to correct astigmatism and presbyopia in order to minimize spectacle dependence. Despite continued advances in preoperative and intraoperative diagnostics, refractive planning, and surgical technology, residual refractive error remains a primary source of dissatisfaction after cataract surgery. The need to enhance refractive outcomes and treat residual astigmatic or spherical refractive errors postoperatively becomes paramount to meeting the expectations of patients in their surgical outcome. This article reviews the potential preoperative and intraoperative pitfalls that can be the source of refractive error, the various options to enhance refractive outcomes, and potential future technologies to limit residual refractive error after cataract surgery.A case of pellucid marginal degeneration (PMD) with cataract where a customized high-power toric intraocular lens (IOL) was implanted is reported. The patient had preoperative corneal astigmatism of 13.96 diopter (D) and a customized toric IOL of 19 D was implanted; postoperative visual acuity was 6/9 on Snellen chart. The visual quality and aberrometric outcome was assessed with a ray-tracing aberrometer. The toric IOL not only gave a better uncorrected visual acuity but also better quality of vision in this patient with corneal astigmatism due to PMD.Amodified hydrodissection technique to prevent intraoperative iris prolapse is presented. The phacoemulsification tip is inserted into the main ocular incision while hydrodissection is performed through a side-port incision. Placement of the phacoemulsification tip in this location prevents iris prolapse. This technique can be used routinely and might be especially applicable in cases with a high risk for iris prolapse, such as in intraoperative floppy iris syndrome.The capsular tension ring (CTR) is a useful aid in cataract surgery involving zonular impairment. In standard implantation with tweezers or injectors there is limited control of the leading eyelet, and this can cause excessive stress on the zonular fibers and lead to damage of the capsular bag. Several techniques have been investigated with the aim of reducing these risks. Herein, a simple new modification of the suture-guided CTR technique is described. Adding a loop to the suture can facilitate manipulation during implantation and during the removal of cortex residues at the end of cataract extraction.PURPOS e To clinically evaluate visual performance of the AcrySof IQ PanOptix TFNT00 and AT LISA tri 839MP intraocular lenses (IOLs) in binocular visual acuity (VA) and to characterize low contrast visual performance at 6 months post-implantation. Setting Multicenter, 15 sites. Design Prospective, parallel-group, randomized, double-masked, postmarketing clinical study. Methods Binocular uncorrected distance (UDVA, 4 m), intermediate (UIVA, 60 cm), near (UNVA, 40 cm) VAs, and binocular defocus curves, were evaluated under photopic lighting conditions. Photopic and mesopic contrast sensitivity with and without glare was assessed. Results The study included182 subjects (62% female; mean age, 66±9.4 years) who were implanted bilaterally with the TFNT00 IOL (n=93) or 839MP IOL (n=89), and binocular VA was evaluated 4 to 6 months (120-180 days) post-implantation. The TFNT00 group showed superior visual outcomes compared with the 839MP group in binocular UIVA (P=0.001), UNVA (P=0.003) and noninferior outcomes in UDVA (95% CI, -0.023 to 0.041; upper limit less then 0.1 logMAR [logarithm of the minimum angle of resolution] [margin of noninferiority]). Mean defocus curve from 0.00 to -3.00 diopter ranged from 0.1 to 0.0 logMAR for both lenses; better mean VA values (logMAR) were observed in the TFNT00 group between -1.50 to -2.50 D compared with 839MP. Contrast sensitivity values were similar between the 2 groups in all conditions. Conclusion The results of this study showed improved visual performance at near and intermediate distances with the TFNT00 IOL compared with the 839MP IOL.Pneumoconiosis is an incurable disease. An online educational booklet for South Asian construction workers has been developed to provide them with knowledge of the disease and its preventive measures. As eye tracking has long been applied to assess users' preferences with regard to the content of commercial products, this approach would likely offer a promising opportunity for an objective assessment of the usability of the developed booklet. This was a mixed-methods study that combined eye tracking and interviews to explore the usability of the educational booklet among South Asian construction workers. Twelve construction workers were invited to read the booklet individually on a laptop computer. this website An eye-tracking device was placed under the computer screen to collect eye tracking data of the participants to measure their attention to the contents of the booklet. Afterward, the participants were invited to attend a semistructured interview to explore their acceptance of and satisfaction with the booklet. Results showed that participants gazed more often and for a longer duration at the working environment that increases pneumoconiosis risk and the preventive measures for pneumoconiosis, and they paid more attention to the pictures. The workers reported that the booklet was useful and informative, and they were satisfied with its design and layout.
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