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Compared with the back propagation neural network and support vector machine, which are commonly used in NO x modeling, the ensemble DBN model has better prediction performance and generalization ability.The geometrical characteristic and the degree of CO2 activation of the CO2-coordinated Ni(0) complexes were investigated computationally by quantum chemical means for bidentate and tridentate ligands of PP, PPMeP, and PNP, and sometimes with co-complexing Fe(II) to differently coordinate CO2. We show that the coordination geometry of the central metal is determined by the ligand geometry. The charge and the energy decomposition analyses show that the charge transfer energy through orbital mixing has a strong correlation with CO2 net charge, while the binding energy cannot due to the lack of the coordination number and the deformation energy of the ligand. Among the examined ligands, PNP with negatively charged secondary amine makes Ni(0) an electron-rich atom, which results in an ∼20% higher CO2 activation than those of PP and PPMeP. In particular, Fe(II)-PNP in the CO2-bridged diatomic complex enhances CO2 activation by another ∼20%, partly through the inductive effect of Fe(II), which pulls electron density from Ni-PNP across the CO2-bridge and partly by the backward donation from Fe(II)-PNP. Therefore, the present study encourages us to design a strongly electron-donating ligand and a CO2-bridged diatomic complex to develop more efficient homogeneous catalyst.Background Arthritis is a cartilage degenerative disease that is mainly induced by the degradation of the cartilage extracellular matrix (ECM), which is found to be regulated by the expression level of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMT-5), an enzyme degrading Aggrecans in the ECM. Feprazone is a classic nonsteroidal anti-inflammatory drug with promising efficacy in arthritis. The present study aims to investigate the protective effect of Feprazone on the degraded Aggrecan in the human chondrocytes induced with tumor necrosis factor-α (TNF-α) and to clarify the underlying mechanism. Methods To investigate the effect of Feprazone, the CHON-001 chondrocytes were stimulated with TNF-α (10 ng/mL) in the presence or absence of Feprazone (3, 6 μM) for 24 h. Mitochondrial membrane potential was evaluated using the Rhodamine 123 assay. The gene expressions of interleukin-1β (IL-1β), interleukin-8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and ADAMTS-5 in the treated chondrocyFeprazone might ameliorate TNF-α-induced loss of Aggrecan via the inhibition of the SOX-4/ADAMTS-5 signaling pathway.Three H-Oil gas oils, heavy atmospheric gas oil (HAGO), light vacuum gas oil (LVGO), heavy vacuum gas oil (HVGO), and two their blends with hydrotreated straight run vacuum gas oils (HTSRVGOs) were cracked on two high unit cell size (UCS) lower porosity commercial catalysts and two low UCS higher porosity commercial catalysts. https://www.selleckchem.com/products/elacestrant.html The cracking experiments were performed in an advanced cracking evaluation fluid catalytic cracking (FCC) laboratory unit at 527 °C, 30 s catalyst time on stream, and catalyst-to-oil (CTO) variation between 3.5 and 7.5 wt/wt The two high UCS lower porosity catalysts were more active and more coke selective. However, the difference between conversion of the more active high UCS lower porosity and low UCS higher porosity catalysts at 7.5 wt/wt CTO decreased in the order 10% (HAGO) > 9% (LVGO) > 6% (HVGO) > 4% (80% HTSRVGO/20% H-Oil VGO). Therefore, the catalyst performance is feedstock-dependent. The four studied catalysts along with a blend of one of them with 2% ZSM-5 were examined in a commercially revamped UOP FCC VSS unit. The lower UCS higher porosity catalysts exhibited operation at a higher CTO ratio achieving a similar conversion level with more active higher UCS lower porosity catalysts. However, the higher UCS lower porosity catalysts made 0.67% Δ coke that was higher than the maximum acceptable limit of 0.64% for this particular commercial FCC unit (FCCU), which required excluding the HVGO from the FCC feed blend. The catalyst system containing ZSM-5 increased the LPG yield but did not have an impact on gasoline octane. It was found that the predominant factor that controls refinery profitability related to the FCCU performance is the FCC slurry oil (bottoms) yield.Designing the mesopore-dominated activated carbon electrodes has witnessed a significant breakthrough in enhancing the electrolyte breakdown voltage and energy density of supercapacitors. Herein, we designed N-doped mesoporous-dominated hierarchical activated carbon (N-dfAC) from the dragon fruit peel, an abundant biomass precursor, under the synergetic effect of KOH as the activating agent and melamine as the dopant. The electrode with the optimum N-doping content (3.4 at. %) exhibits the highest specific capacitance of 427 F g-1 at 5 mA cm-2 and cyclic stability of 123% capacitance retention until 50000 charge-discharge cycles at 500 mA cm-2 in aqueous 6 M KOH electrolytes. We designed a 4 V symmetric coin cell supercapacitor cell, which exhibits a remarkable specific energy and specific power of 112 W h kg-1 and 3214 W kg-1, respectively, in organic electrolytes. The cell also exhibits a significantly higher cycle life (109% capacitance retention) after 5000 GCD cycles at the working voltage of ≥3.5 V than commercial YP-50 AC (∼60% capacitance retention). The larger Debye length of the diffuse ion layer permitted by the mesopores can explain the higher voltage window, and the polar N-doped species in the dfAC enhance capacitance and ion transport. The results endow a new path to design high-capacity and high-working voltage EDLCs from eco-friendly and sustainable biomass materials by properly tuning their pore structures.Hanging cell culture inserts are most widely used in vitro cell culture devices, which provide a freestanding multichamber setup for various co-culture and triculture systems. Apart from being costly, the commercial inserts do not provide enough choices regarding polymer types and pore sizes. Most importantly, commercially available inserts are two-dimensional multiporous membrane-based devices. Herein, we report a one-step fabrication process of the multifunctional nanofiber-based permeable hanging cell culture insert using electrospinning. These fabricated nanofibrous membranes' attached inserts have advantages such as low cost, ready availability, easy fabrication, tunable porosity, autoclavability, and biomaterial-based nanofibrous membranes. The inserts without nanofibrous membrane can also be reused by autoclaving them and electrospun nanofibrous membrane on it according to the application. We have also confirmed its suitability for extensive use in the field of in vitro cell culture by analyzing its adherence and toxicity results on breast cancer cell line (MCF-7).
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