Notes

Carcinomatous-like mastitis on account of axillary lymphadenopathy within a the event of nasopharyngeal carcinoma: An instance statement.
Sandy beaches are highly dynamic systems which provide natural protection from the impact of waves to coastal communities. With coastal erosion hazards predicted to increase globally, data to inform decision making on erosion mitigation and adaptation strategies is becoming critical. However, multi-temporal topographic data over wide geographical areas is expensive and time consuming and often requires highly trained professionals. In this study we demonstrate a novel approach combining citizen science with low-cost unmanned aerial vehicles that reliably produces survey-grade morphological data able to model sediment dynamics from event to annual scales. The high-energy wave-dominated coast of south-eastern Australia, in Victoria, is used as a field laboratory to test the reliability of our protocol and develop a set of indices to study multi-scale erosional dynamics. We found that citizen scientists provide unbiased data as accurate as professional researchers. We then observed that open-ocean beaches mobilise three times as much sediment as embayed beaches and distinguished between slowed and accelerated erosional modes. The data was also able to assess the efficiency of sand nourishment for shore protection. Our citizen science protocol provides high quality monitoring capabilities, which although subject to important legislative preconditions, it is applicable in other parts of the world and transferable to other landscape systems where the understanding of sediment dynamics is critical for management of natural or anthropogenic processes.Post-translational modification of proteins, such as tyrosine phosphorylation, plays a major role in driving the oncogenic activity of oncogenes. WAVE3 (WASF3), an adaptor and actin cytoskeleton remodeling protein, contributes to cell migration, cancer cell invasion, and metastasis. WAVE3 plays a vital role in the progression and metastasis of triple negative breast cancer (TNBC), in part through the regulation of cancer stem cells (CSCs). Several studies have shown that WAVE3 tyrosine phosphorylation is required for its oncogenic activity. Moreover, our recent study showed that the proline rich domain (PRD) of WAVE3 is required for maintenance of the CSC niche in breast cancer by regulating the nuclear translocation of the CSC-specific nuclear transcription factor YB1. Here, we show that the PRD domain of WAVE3 and its phosphorylation are essential for driving the oncogenic activity of WAVE3. We show that phosphorylation of WAVE3 PRD is essential for migration and invasion of breast cancer cells in vitro, as well as tumor growth and metastasis in vivo. Mechanistically, we show that phosphorylation of the WAVE3 PRD is essential for interaction between WAVE3 and YB1. Loss of PRD phosphorylation inhibits such interaction and the YB1-mediated activation of expression of CSC markers, as well as the WAVE3 mediated activation of EMT. Together, our study identifies a novel role of WAVE3 and its PRD domain in the regulation of the invasion metastasis cascade in BC that is independent of the known function of WAVE3 as an actin cytoskeleton remodeling protein through the WAVE regulatory complex (WRC).Direct measurement of critical cooling rates has been challenging and only determined for a minute fraction of the reported metallic glass forming alloys. Here, we report a method that directly measures critical cooling rate of thin film metallic glass forming alloys in a combinatorial fashion. Based on a universal heating architecture using indirect laser heating and a microstructure analysis this method offers itself as a rapid screening technique to quantify glass forming ability. We use this method to identify glass forming alloys and study the composition effect on the critical cooling rate in the Al-Ni-Ge system where we identified Al51Ge35Ni14 as the best glass forming composition with a critical cooling rate of 104 K/s.We herein described a rapid, sensitive, and selective colorimetric sensing platform for biothiols in human serum, which relies on the dual functions of biothiols as anti-etching and aggregating agent for silver nanoprisms (AgNPRs). In principle, the target biothiols that bind to the surface of AgNPRs through Ag-S covalent interactions protect the AgNPRs from being etched by chloride ion (Cl-) in human serum, thus exhibiting the blue/purple color that is indicative of AgNPRs. learn more On the other hand, the color of AgNPRs turned to yellow in the absence of biothiols or the presence of non-sulfur-containing amino acids, indicating the formation of small silver nanoparticles (AgNPs). Importantly, we found that individual biothiols (Hcy, Cys, and GSH) exert not only the anti-etching effect, but also the aggregating effect on AgNPRs, which can be modulated by simply tuning the pH conditions, and this consequently allows for the discriminative detection of each biothiol. Based on this simple and cost-effective strategy, we successfully determined the Hcy, Cys, and GSH in human serum with high sensitivity and selectivity within 10 min, demonstrating the diagnostic capability and potential in practical applications.Applying organic matters into the soil would help to improve soil quality and sustain crop production. In addition, the small molecular organic matters could be active in influencing soil nutrient cycling and crop development. Thus, this study has firstly induced a new technology of quick artificial decomposition to produce fertilizers containing small molecular organic compounds from crop residues and other biological wastes. The fertilizers were produced via the quick artificial decomposition from biological wastes. The small organic species in the fertilizers were identified by the LC-MS. Field experiments of kiwifruit were conducted to test the effects of fertilizers. In total, 341 species of small organic matters have been determined in the produced fertilizers. The results showed that the organic fertilizers could significantly increase the yields of kiwifruit by 15.2% in contrast with mineral fertilizer treatments. Whereas, the organic fertilizers could enhance the contents of nutritive components in kiwifruits.
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