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Exploration of the Action involving Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing.
Digital optical phase conjugation (DOPC) is a newly developed technique in wavefront shaping to control light propagation through complex media. Currently, DOPC has been demonstrated for the reconstruction of two- and three-dimensional targets and enabled important applications in many areas. Nevertheless, the reconstruction results are only phase conjugated to the original input targets. Herein, we demonstrate that DOPC could be further developed for creating structured light beams through a multimode fiber (MMF). By applying annular filtering in the virtual Fourier domain of the acquired speckle field, we realize the creation of the quasi-Bessel and donut beams through the MMF. In principle, arbitrary amplitude and/or phase circular symmetry filtering could be performed in the Fourier domain, thus generating the corresponding point spread functions. We expect that the reported technique can be useful for super-resolution endoscopic imaging and optical manipulation through MMFs.High-resolution, single-shot on-axis digital holography is proposed. Generally, an on-axis configuration samples carrier fringes with higher spatial resolution compared to an off-axis configuration. However, the reconstructed image is obtained with unnecessary images of a conjugate image and a zero-order beam. The proposed method uses a phase-modulated illumination beam and image processing to eliminate these unnecessary images. Since time-division and parallel phase-shifting methods are not required, the proposed method has higher temporal and spatial resolutions. During image processing, the conjugate image is removed by filtering on the Fresnel domain while keeping most of the information of the object image intact. The usefulness of the proposed method is confirmed by a numerical simulation and an optical experiment.A new luminance calculation method that accounts for mesopic vision and fog penetration ability is presented. This method aims to select a suitable light source for street lighting and is obtained using the mesopic luminance calculation and transmittance calculation methods at each individual wavelength. Additionally, the new method was evaluated using six LED light sources between 3500 and 6000 K. Overall, the calculation results indicate that suitable LEDs' CCT decreases with an increase of luminance for low transmittance rates. However, for high transmittance rates, high CCT LED lamps are the most suitable for street lighting. The recommended CCT of LED light sources for street lighting under different visibility and luminance conditions is presented.In this paper, a 1550 nm five-channel all-fiber homodyne laser Doppler vibrometer with high sensitivity and good signal probing probability is presented. Under the anechoic tank, standing on an airborne platform above the water surface 3 m away, the calibration experiments of the designed system are conducted. The minimum detectable sound pressure level is up to 101.73 dB re 1 µPa at 10 kHz under the hydrostatic water surface condition, and the time distribution of the final outputs are consistent with that of the underwater sound transducer. For the hydrodynamic detection capability, with the help of a 1064 nm high-pulse-energy laser whose pulse energy is 6J, pulse duration is about 8 ns, and repetition rate is 1 Hz, the system performance is tested in Qiandao Lake. And the signal probing probability of the whole sensing system is up to 59.77%.This paper presents an integrated principal component analysis (IPCA) technique for denoising phase-sensitive optical time domain reflectometry (Φ-OTDR) sensing data for vibration detection. As one of the key distributed optical fiber sensing technologies, it has attracted great attention, mainly due to its high sensitivity, fast response time, dynamic range, and vibration detection abilities. selleck To enhance vibration detection along the sensing fiber, an appropriate denoising method must be carefully selected. Hence, the PCA that can effectively reduce noise on signals while preserving significant details of the denoised signal is identified. It was then applied on the said signal after digital down-conversion where the noise was greatly reduced. Then angle and phase unwrapping was performed and the vibration was clearly detected with a significant enhancement of the signal-to-noise ratio. As proof of concept, the theoretical analysis and an experimental demonstration of a vibration sensing range of 800 m are presented.With regard to surface-enhanced Raman spectroscopy (SERS), the preparation of substrates with high homogeneity and low cost remains a challenge. In this paper, cheap commercial DVD-R plates were adopted as supports, whose 3D periodic structure was transferred onto the surface of flexible polydimethylsiloxane (PDMS) easily. Then, silver nanoparticles were grown both on DVD and PDMS substrates by the in situ reduction method, and the SERS performances of these two substrates were investigated. The results confirmed that the PDMS-based substrate exhibited better enhancement performance and higher uniformity (RSD=4.16%). In addition, due to the flexibility and transparency of PDMS, it is not restricted by the surface shape of the object when applied in in situ detection. This low-cost, simple method will be widely used in the in situ detection of surfaces of objects of any shape.Interferometric laser ranging is an enabling technology for high-precision satellite-to-satellite tracking within the context of Earth observation, gravitational wave detection, or formation flying. In orbit, the measurement system is affected by environmental influences, particularly satellite attitude jitter and temperature fluctuations, imposing an instrument design with a high level of thermal stability and insensitivity to rotations around the spacecraft center of mass. The new design concept presented here combines different approaches for dynamic heterodyne laser ranging and features the inherent beam-tracking capabilities of a retroreflector in a mono-axial configuration. It allows for a continuously adjustable distance between the optical bench and the location of its fiducial point, facilitating future inter-satellite tracking with nanometer accuracy, e.g., the next-generation gravity mission.
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