Notes

Atropo-Enantioselective Oxidation-Enabled Iridium(Three)-Catalyzed C-H Arylations using Aryl Boronic Esters.
ve similar levels of motivation and intention to quit smoking as those without SMI. However, they are disadvantaged by the reduced support received from their family physicians and lower cessation medication usage. Efforts to promote the implementation of smoking cessation treatment guidelines will help promote smoking abstinence among PWSMI.The study considered two major facets of interpersonal coordination, namely, behavior matching (posture mirroring) and interactional synchrony, and investigated whether interpersonal coordination enhanced empathic accuracy. Interactional synchrony was further classified into simultaneous movement and interaction rhythms. Participants engaged in an eight-minute conversation with a same-gender unacquainted partner and an empathic accuracy task. Each participant viewed the interaction video and reported their thoughts and feelings at pre-determined points of time. Afterward, they rewatched the video and inferred the thoughts and feelings of their partners. The study employed OpenPose, 2D pose estimation software of human body, to quantify posture and bodily movement, which were used to determine coordination. The results indicated that behavior matching was positively associated with empathic accuracy, whereas rhythmic convergence in synchrony was negatively associated with accuracy in female dyads. The additional analysis explored the temporal relationship between coordination and accuracy, which indicated a cause-effect tendency during interactions.
This retrospective patient survey aimed to assess the prevalence of temporomandibular disorders (TMD) before and after curative oncological treatment and to identify possible risk factors.

Patients with squamous cell carcinoma in the tonsil or base of the tongue were included (
 = 217). Medical records were collected to assess TMD prevalence before oncological treatment and at 6- and 12-month follow-up. Fisher's test and Pitman's test were used.

Significantly reduced mouth opening was observed after oncological treatment at 6- and 12-month follow-up (
 < .001). Symptoms from the temporomandibular joint and jaw muscles plus pain upon palpation (
 = .0083,
 < .001, respectively) and self-reported pain upon chewing (<0.001) and opening the mouth (<0.001) increased 12 months following radiotherapy. Pain and degree of mouth opening prior to treatment, self-reported depression, overall health status, brachytherapy and jaw exercise during radiotherapy were factors affecting the increase of TMD symptoms.

All TMD symptoms escalated significantly one year after radiotherapy except self-reported sounds from the temporomandibular joint. Reduction in the degree of mouth opening and pain in the jaw muscles and the temporomandibular joint when opening the mouth and upon chewing were commonly reported symptoms following radiotherapy. Several potential risk factors were identified.
All TMD symptoms escalated significantly one year after radiotherapy except self-reported sounds from the temporomandibular joint. Reduction in the degree of mouth opening and pain in the jaw muscles and the temporomandibular joint when opening the mouth and upon chewing were commonly reported symptoms following radiotherapy. Several potential risk factors were identified.Evidence indicates that the transcranial direct current stimulation (tDCS) has the potential to transiently modulate cognitive function, including age-related changes in brain performance. Only a small number of studies have explored the interaction between the stimulation sites on the scalp, task performance, and brain network connectivity within the frame of physiological aging. We aimed to evaluate the spread of brain activation in both young and older adults in response to anodal tDCS applied to two different scalp stimulation sites Prefrontal cortex (PFC) and posterior parietal cortex (PPC). EEG data were recorded during tDCS stimulation and evaluated using the Small World (SW) index as a graph theory metric. Before and after tDCS, participants performed a behavioral task; a performance accuracy index was computed and correlated with the SW index. Results showed that the SW index increased during tDCS of the PPC compared to the PFC at higher EEG frequencies only in young participants. tDCS at the PPC site did not exert significant effects on the performance, while tDCS at the PFC site appeared to influence task reaction times in the same direction in both young and older participants. In conclusion, studies using tDCS to modulate functional connectivity and influence behavior can help identify suitable protocols for the aging brain.In this paper, we introduce VPNet, a novel model-driven neural network architecture based on variable projection (VP). Applying VP operators to neural networks results in learnable features, interpretable parameters, and compact network structures. This paper discusses the motivation and mathematical background of VPNet and presents experiments. The VPNet approach was evaluated in the context of signal processing, where we classified a synthetic dataset and real electrocardiogram (ECG) signals. Compared to fully connected and one-dimensional convolutional networks, VPNet offers fast learning ability and good accuracy at a low computational cost of both training and inference. Based on these advantages and the promising results obtained, we anticipate a profound impact on the broader field of signal processing, in particular on classification, regression and clustering problems.Social marketing campaigns promoting moderate to vigorous physical activity (MVPA) may be more successful when associated with strong brands. Little is known regarding how brand constructs such as brand resonance may be related to MVPA and its antecedents (e.g., having a physical activity identity). A better knowledge of these constructs and their relationships can reveal how to strengthen brands to make them more useful for interventions. Y-27632 ic50 The purpose of this study was to test a model linking ParticipACTION (a Canadian social marketing organization) brand constructs (brand affective attitude, identification, resonance), MVPA antecedents (behavioral affective attitude, identity), and MVPA. This study used a cross-sectional online survey design with a representative Canadian adult sample of 1,475 people (M age = 49.36; 49.1% female). Path analysis was conducted to test the model. Overall, the model fit the data well, demonstrating positive associations between brand affective attitude and identification, identification and resonance, resonance and both behavioral affective attitude and identity, behavioral affective attitude and both identity and MVPA, and identity and MVPA. The results suggest that building brand resonance is important for linking branding to MVPA variables. Brand management activities designed to target brand affective attitude may be crucial to helping people feel strong resonance with a brand in a way that supports behavior change.This paper designs and builds a small constructed wetland test site to study the internal hydraulic characteristics of different types of constructed wetlands, conducts NaCl pulse tracing experiments, and fits the residence time distribution (RTD) with the CSTRs+PFD model (Continuous Stirred-Tank Reactor model in parallel with Plug Flow with Dispersion model). The results showed that, among the six types of constructed wetlands, hydraulic parameters of horizontal subsurface flow constructed wetlands with baffles had the best performance, with a tracer recovery rate (F(t)) reaching 43.67% and hydraulic efficiency (λ) reaching 0.81. The addition of baffles slowed flow velocity, increased mean hydraulic retention time (Tm) and peak residence time (Tp), and reduced the short circuits phenomenon. The velocity of internal water flow increased during the horizontal and vertical deflections, which could well avoid the stagnation phenomenon caused by complicated flow state, thereby improving the hydraulic efficiency (λ). The CSTRs+PFD model can better fit the RTD of 6 different types of constructed wetlands. The peak value of the fitted curve, the time to reach the peak and the slope of the curve are all very similar to the measured RTD.1. AbstractAtopic dermatitis (AD) is characterized by progressive skin inflammation. In addition, sulforaphane is an isothiocyanate organosulfur compound from cruciferous vegetables. Sulforaphane was reported to ameliorate inflammatory responses. Therefore, this study was conducted to evaluate protective effects of sulforaphane in AD through affecting the balance between pro-inflammatory and anti-inflammatory cytokines and to evaluate its effect on AD-induced activation of apoptotic pathway. The method of repeated rubbing of 2,4-dinitrochlorobenzene (DNCB) on shaved dorsal skin and ears of mice was used for induction of AD. After development of AD, part of mice was injected with 1 mg/kg sulforaphane, subcutaneously three times weekly. Samples of skin was isolated for assessment of gene and protein expression of 8-hydroxy2'-deoxyguanosine, IgE, NFκB, TNF-α, IL-1β, IL-4, IL-10, Nrf2 and caspase-3. In addition, skin sections from different groups were stained with anti-caspase-3 antibodies. Mice in AD group were characterized by increased gene and protein expression of 8-hydroxy2'-deoxyguanosine, IgE, NFκB, TNF-α, IL-1β and caspase-3 associated with reduced expression of Nrf2, IL-4 and IL-10. Treatment of AD mice with sulforaphane significantly reduced the number of scratches, dermatitis score and ear thickness. In addition, sulforaphane significantly attenuated the gene and protein expressions produced by AD. Therefore, sulforaphane alleviated AD induced in mice through inhibition of oxidative stress, oxidative DNA damage, inflammation and apoptosis.Gap junctions are intercellular membrane channels consisting of connexin proteins, which contribute to direct cytoplasmic exchange of small molecules, substrates and metabolites between adjacent cells. These channels play important roles in neuronal differentiation, maintenance, survival and function. Gap junctions regulate differentiation of neurons from embryonic, neural and induced pluripotent stem cells. In addition, they control transdifferentiation of neurons from mesenchymal stem cells. The expression and levels of several connexins correlate with cell cycle changes and different stages of neurogenesis. Connexins such as Cx36, Cx45, and Cx26, play a crucial role in neuronal function. Several connexin knockout mice display lethal or severely impaired phenotypes. Aberrations in connexin expression is frequently associated with various neurodegenerative disorders. Gap junctions also act as promising therapeutic targets for neuronal regenerative medicine, because of their role in neural stem cell integration, injury and remyelination.
We identified common and unique barriers and facilitators of evidence-based suicide prevention practices across primary care practices with integrated behavioral health services and specialty mental health settings to identify generalizable strategies for enhancing future implementation efforts.

Twenty-six clinicians and practice leaders from behavioral health (
 = 2 programs) and primary care (
 = 4 clinics) settings participated. Participation included a semi-structured qualitative interview on barriers and facilitators to implementing evidence-based suicide prevention practices. Within that interview, clinicians participated in a chart-stimulated recall exercise to gather additional information about decision making regarding suicide screening. Interview guides and qualitative coding were informed by leading frameworks in implementation science and behavioral science, and an integrated approach to interpreting qualitative results was used.

There were a number of similar themes associated with implementation of suicide prevention practices across settings and clinician types, such as the benefits of inter-professional collaboration and uncertainties about managing suicidality once risk was disclosed.
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