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This paper describes a methodology that extracts key morphological features from histological breast cancer images in order to automatically assess Tumour Cellularity (TC) in Neo-Adjuvant treatment (NAT) patients. The response to NAT gives information on therapy efficacy and it is measured by the residual cancer burden index, which is composed of two metrics TC and the assessment of lymph nodes. The data consist of whole slide images (WSIs) of breast tissue stained with Hematoxylin and Eosin (H&E) released in the 2019 SPIE Breast Challenge. The methodology proposed is based on traditional computer vision methods (K-means, watershed segmentation, Otsu's binarisation, and morphological operations), implementing colour separation, segmentation, and feature extraction. Correlation between morphological features and the residual TC after a NAT treatment was examined. Linear regression and statistical methods were used and twenty-two key morphological parameters from the nuclei, epithelial region, and the full image were extracted. Subsequently, an automated TC assessment that was based on Machine Learning (ML) algorithms was implemented and trained with only selected key parameters. The methodology was validated with the score assigned by two pathologists through the intra-class correlation coefficient (ICC). The selection of key morphological parameters improved the results reported over other ML methodologies and it was very close to deep learning methodologies. MEK inhibitor These results are encouraging, as a traditionally-trained ML algorithm can be useful when limited training data are available preventing the use of deep learning approaches.We present and compare the designs of three types of neutron microscopes for high-resolution neutron imaging. Like optical microscopes, and unlike standard neutron imaging instruments, these microscopes have both condenser and image-forming objective optics. The optics are glancing-incidence axisymmetric mirrors and therefore suitable for polychromatic neutron beams. The mirrors are designed to provide a magnification of 10 to achieve a spatial resolution of better than 10 μm. The resolution of the microscopes is determined by the mirrors rather than by the L/Dratio as in conventional pinhole imaging, leading to possible dramatic improvements in the signal rate. We predict the increase in the signal rate by at least two orders of magnitude for very high-resolution imaging, which is always flux limited. Furthermore, in contrast to pinhole imaging, in the microscope, the samples are placed far from the detector to allow for a bulky sample environment without sacrificing spatial resolution.In this work, we present an ensemble of descriptors for the classification of virus images acquired using transmission electron microscopy. We trained multiple support vector machines on different sets of features extracted from the data. We used both handcrafted algorithms and a pretrained deep neural network as feature extractors. The proposed fusion strongly boosts the performance obtained by each stand-alone approach, obtaining state of the art performance.Vulnerable Road User (VRU) detection is a major application of object detection with the aim of helping reduce accidents in advanced driver-assistance systems and enabling the development of autonomous vehicles. Due to intrinsic complexity present in computer vision and to limitations in processing capacity and bandwidth, this task has not been completely solved nowadays. For these reasons, the well established YOLOv3 net and the new YOLOv4 one are assessed by training them on a huge, recent on-road image dataset (BDD100K), both for VRU and full on-road classes, with a great improvement in terms of detection quality when compared to their MS-COCO-trained generic correspondent models from the authors but with negligible costs in forward pass time. Additionally, some models were retrained when replacing the original Leaky ReLU convolutional activation functions from original YOLO implementation with two cutting-edge activation functions the self-regularized non-monotonic function (MISH) and its self-gated counterpart (SWISH), with significant improvements with respect to the original activation function detection performance. Additionally, some trials were carried out including recent data augmentation techniques (mosaic and cutmix) and some grid size configurations, with cumulative improvements over the previous results, comprising different performance-throughput trade-offs.This article considers the task of handwritten text recognition using attention-based encoder-decoder networks trained in the Kazakh and Russian languages. We have developed a novel deep neural network model based on a fully gated CNN, supported by multiple bidirectional gated recurrent unit (BGRU) and attention mechanisms to manipulate sophisticated features that achieve 0.045 Character Error Rate (CER), 0.192 Word Error Rate (WER), and 0.253 Sequence Error Rate (SER) for the first test dataset and 0.064 CER, 0.24 WER and 0.361 SER for the second test dataset. Our proposed model is the first work to handle handwriting recognition models in Kazakh and Russian languages. Our results confirm the importance of our proposed Attention-Gated-CNN-BGRU approach for training handwriting text recognition and indicate that it can lead to statistically significant improvements (p-value less then 0.05) in the sensitivity (recall) over the tests dataset. The proposed method's performance was evaluated using handwritten text databases of three languages English, Russian, and Kazakh. It demonstrates better results on the Handwritten Kazakh and Russian (HKR) dataset than the other well-known models.The empirical wavelet transform is an adaptive multi-resolution analysis tool based on the idea of building filters on a data-driven partition of the Fourier domain. However, existing 2D extensions are constrained by the shape of the detected partitioning. In this paper, we provide theoretical results that permits us to build 2D empirical wavelet filters based on an arbitrary partitioning of the frequency domain. We also propose an algorithm to detect such partitioning from an image spectrum by combining a scale-space representation to estimate the position of dominant harmonic modes and a watershed transform to find the boundaries of the different supports making the expected partition. This whole process allows us to define the empirical watershed wavelet transform. We illustrate the effectiveness and the advantages of such adaptive transform, first visually on toy images, and next on both unsupervised texture segmentation and image deconvolution applications.The widespread deployment of facial recognition-based biometric systems has made facial presentation attack detection (face anti-spoofing) an increasingly critical issue. This survey thoroughly investigates facial Presentation Attack Detection (PAD) methods that only require RGB cameras of generic consumer devices over the past two decades. We present an attack scenario-oriented typology of the existing facial PAD methods, and we provide a review of over 50 of the most influenced facial PAD methods over the past two decades till today and their related issues. We adopt a comprehensive presentation of the reviewed facial PAD methods following the proposed typology and in chronological order. By doing so, we depict the main challenges, evolutions and current trends in the field of facial PAD and provide insights on its future research. From an experimental point of view, this survey paper provides a summarized overview of the available public databases and an extensive comparison of the results reported in PAD-reviewed papers.X-ray plenoptic cameras acquire multi-view X-ray transmission images in a single exposure (light-field). Their development is challenging designs have appeared only recently, and they are still affected by important limitations. Concurrently, the lack of available real X-ray light-field data hinders dedicated algorithmic development. Here, we present a physical emulation setup for rapidly exploring the parameter space of both existing and conceptual camera designs. This will assist and accelerate the design of X-ray plenoptic imaging solutions, and provide a tool for generating unlimited real X-ray plenoptic data. We also demonstrate that X-ray light-fields allow for reconstructing sharp spatial structures in three-dimensions (3D) from single-shot data.We developed a high-throughput mapping workflow, which centers on deep learning (DL) convolutional neural network (CNN) algorithms on high-performance distributed computing resources, to automatically characterize ice-wedge polygons (IWPs) from sub-meter resolution commercial satellite imagery. We applied a region-based CNN object instance segmentation algorithm, namely the Mask R-CNN, to automatically detect and classify IWPs in North Slope of Alaska. The central goal of our study was to systematically expound the DLCNN model interoperability across varying tundra types (sedge, tussock sedge, and non-tussock sedge) and image scene complexities to refine the understanding of opportunities and challenges for regional-scale mapping applications. We corroborated quantitative error statistics along with detailed visual inspections to gauge the IWP detection accuracies. We found promising model performances (detection accuracies 89% to 96% and classification accuracies 94% to 97%) for all candidate image scenes with varying tundra types. The mapping workflow discerned the IWPs by exhibiting low absolute mean relative error (AMRE) values (0.17-0.23). Results further suggest the importance of increasing the variability of training samples when practicing transfer-learning strategy to map IWPs across heterogeneous tundra cover types. Overall, our findings demonstrate the robust performances of IWPs mapping workflow in multiple tundra landscapes.Bragg edge tomography was carried out on novel, ultra-thick, directional ice templated graphite electrodes for Li-ion battery cells to visualise the distribution of graphite and stable lithiation phases, namely LiC12 and LiC6. The four-dimensional Bragg edge, wavelength-resolved neutron tomography technique allowed the investigation of the crystallographic lithiation states and comparison with the electrode state of charge. The tomographic imaging technique provided insight into the crystallographic changes during de-/lithiation over the electrode thickness by mapping the attenuation curves and Bragg edge parameters with a spatial resolution of approximately 300 µm. This feasibility study was performed on the IMAT beamline at the ISIS pulsed neutron spallation source, UK, and was the first time the 4D Bragg edge tomography method was applied to Li-ion battery electrodes. The utility of the technique was further enhanced by correlation with corresponding X-ray tomography data obtained at the Diamond Light Source, UK.Circular cone-beam (CCB) Computed Tomography (CT) has become an integral part of industrial quality control, materials science and medical imaging. The need to acquire and process each scan in a short time naturally leads to trade-offs between speed and reconstruction quality, creating a need for fast reconstruction algorithms capable of creating accurate reconstructions from limited data. In this paper, we introduce the Neural Network Feldkamp-Davis-Kress (NN-FDK) algorithm. This algorithm adds a machine learning component to the FDK algorithm to improve its reconstruction accuracy while maintaining its computational efficiency. Moreover, the NN-FDK algorithm is designed such that it has low training data requirements and is fast to train. This ensures that the proposed algorithm can be used to improve image quality in high-throughput CT scanning settings, where FDK is currently used to keep pace with the acquisition speed using readily available computational resources. We compare the NN-FDK algorithm to two standard CT reconstruction algorithms and to two popular deep neural networks trained to remove reconstruction artifacts from the 2D slices of an FDK reconstruction.
Website: https://www.selleckchem.com/MEK.html
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