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First-Line Aldoxorubicin as opposed to Doxorubicin inside Metastatic or Locally Innovative Unresectable Soft-Tissue Sarcoma: A Stage 2b Randomized Medical study.
This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Krüppel-like factor 5 plays an oncogenic role and has diverse functions in cancer cells. However, correlation between Krüppel-like factor 5 and clinical outcome has not been demonstrated in patients with colorectal cancer and colorectal liver metastasis. Herein, we analyzed 65 patients with colorectal cancer who developed colorectal liver metastasis. Clinical effects were assessed through immunohistochemical analysis of primary colorectal cancer lesions and metastatic liver lesions. dBET6 ic50 High expression of Krüppel-like factor 5 in these tissues correlated with the presence of vascular invasion, elevated serum carbohydrate antigen 19-9 levels, large diameters of metastatic liver tumors, and poor prognosis following surgery. Multivariate analyses revealed that high expression of Krüppel-like factor 5 was an independent prognostic factor. Increased expression of Krüppel-like factor 5 in both colorectal cancer primaries and colorectal liver metastasis was significantly associated with shorter overall survival time and time to surgical failure. Krüppel-like factor 5 expression positively correlated with Ki-67 and c-Myc expression in colorectal cancer tissues. In vitro experiments with colon cancer cell lines demonstrated that siRNA knockdown of Krüppel-like factor 5 inhibited cell proliferation. Western blot analyses revealed that knockdown of Krüppel-like factor 5 expression reduced cyclin D1 and c-Myc expression. It also impaired the stem-cell like properties of cancer cells in tumorsphere formation assays. Furthermore, anoikis assay indicated that Krüppel-like factor 5 contributed to anoikis resistance. High Krüppel-like factor 5 expression is associated with poor prognosis in patients with colorectal cancer and liver metastasis by promoting cell proliferation and cancer stem cell-like properties. This article is protected by copyright. All rights reserved.OBJECTIVE To estimate the prevalence of Chagas disease in pregnant women and the vertical transmission of the disease. METHODS Observational studies were identified from eight electronic databases and details on study design, population, and prevalence of Chagas disease were extracted. The data were pooled using a random-effects model and choropleth maps were created based on geopolitical regions and countries. RESULTS The search identified 7,788 articles, of which 50 were eligible. We observed a 9% prevalence of Chagas disease among pregnant women in the Americas (95% confidence interval [CI] 8-10, I2 = 99.96%). High disease prevalence was identified in pregnant women in South American countries (12%, 95% CI 11-13), while lower values were identified in pregnant women in North America (2%, 95% CI 1-3). Countries with medium Human Development Index (HDI) had a higher prevalence of Chagas disease in pregnant women (15%, 95% CI 13-16, I2 = 99.98%) than countries with high HDI (3%, 95% CI 2-3). The rate of vertical transmission in the continent was 2% (95% CI 1- 2). The statistical analysis showed that this heterogeneity was explained by the study design, region of the Americas, and mean income of the country. CONCLUSION South and Central American countries have a high prevalence and vertical transmission of Chagas disease. Therefore, systematic screens for this disease during the prenatal period are necessary in addition to the diagnosis and treatment of children at risk for Trypanosoma cruzi infection. This article is protected by copyright. All rights reserved.Androgenetic alopecia (AGA) is a multi-factorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Shortly after birth, mammals are colonized by a multitude of microbes derived from the mother and the environment. Studies in model organisms have demonstrated that the structure and composition of the gut microbiome of offspring steadily mature with increasing diversity during nursing and weaning (Sommer & Bäckhed, 2013). This period of microbiome assembly is critical for young mammals because the gut microbes they acquire will help train their immune system (Lathrop et al., 2011) with potential long-lasting effects on their health (Cox et al., 2014). In an article in this issue of Molecular Ecology, Stoffel et al. (2020) investigated the gut microbiota of northern elephant seals (Mirounga angustirostris) during a key developmental window. A month after giving birth, elephant seal mothers stop nursing their pups and return to the sea. As a consequence, their pups go from a diet of milk rich in fat to abruptly enter a post-weaning fasting period which lasts for about two months while they remain with the colony. This particular life-history trait therefore offered the authors a unique and exciting opportunity to evaluate intrinsic factors contributing to gut microbiota development in a wild marine mammal. This article is protected by copyright. All rights reserved.BACKGROUND AND OBJECTIVES Metabolic syndrome (MetS) is an independent risk factor for cardiovascular disease (CVD), in which platelet hyperactivation plays a pivotal role. The purpose of this study was to evaluate platelet function in MetS patients using Platelet Function Analyzer-100 (PFA-100) and to explore the risk factors for platelet hyperactivity in MetS. SUBJECTS AND METHODS We investigated participants who were enrolled for health check-up in our department. Routine physical examinations and fasting blood sample tests were performed when participants visited the hospital. MetS was defined as ≥3 of the risk factors according to the Harmonized criteria central obesity, hypertension (HP), hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C) and hyperglycemia. Participants were divided into a MetS group (≥3), normal control (NC) group (0) and non-MetS group (1-2) according to the numbers of the five risk factors. Platelet function was tested by PFA-100, which measures the time taken for blood to occlude an aperture (closure time [CT]).
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