Notes

Affiliation involving HLA-DR2-Related Haplotype (HLA-DRB5*01-DRB1*1501-DQB1*0602) in People along with Multiple Sclerosis inside Khuzestan Province.
While evidence exists of an association between maternal antenatal anxiety and offspring's behavioral outcomes, the role played by maternal care in explaining this link has been poorly investigated.

The current study aimed to investigate the mediating/moderating role of maternal sensitivity in the association between maternal antenatal trait anxiety and toddlers' behavioral problems and temperament, taking also into account potential confounders. Analyses were also replicated for maternal antenatal state anxiety and depression.

Ninety women filled in the State-Trait Anxiety Questionnaire and the Edinburgh Postnatal Depression Scale to assess anxiety/depressive symptoms during the third trimester of pregnancy (34-36weeks of gestation) and 14months post-partum. They also filled in the Child Behavior Checklist and the Infant Behavior Questionnaire to evaluate their 14-month-olds' behavioral problems and negative affectivity, respectively. Maternal sensitivity was assessed through the Emotional Availability Scales.

Maternal antenatal trait anxiety was associated with internalizing, but not externalizing, problems. Selleckchem β-Nicotinamide Interestingly, maternal sensitivity moderated the association between antenatal trait anxiety and externalizing problems. Conversely, antenatal maternal depression was significantly associated with toddlers' negative affectivity.

Our findings contribute to shed light on the association between maternal antenatal anxiety and child behaviors, as well as on the role played by parenting in moderating this link, with promising implications for targeted interventions.
Our findings contribute to shed light on the association between maternal antenatal anxiety and child behaviors, as well as on the role played by parenting in moderating this link, with promising implications for targeted interventions.The conformational preferences of several α-1,6-linear and α-1,3-branched isomalto-oligosaccharides were investigated by NMR and MD-simulations. Right-handed helical structure contributed to the solution geometry in isomaltotriose and isomaltotetraose with one nearly complete helix turn and stabilizing intramolecular hydrogen bonds in the latter by MD-simulation. Decreased helix contribution was observed in α-1,3-glucopyranosyl- and α-1,3-isomaltosyl-branched saccharide chains. Especially the latter modification was predicted to cause a more compact structure consistent with literature rheology measurements as well as with published dextranase-resistant α-1,3-branched oligosaccharides. The findings presented here are significant because they shed further light on the conformational preference of isomalto-oligosaccharides and provide possible help for the design of dextran-based drug delivery systems or for the targeted degradation of capsular polysaccharides by dextranases in multi-drug resistant bacteria.Glucans are the most abundant natural polysaccharides across the living kingdom with tremendous biological activities. Now a days, α-D-glucans are gaining importance as a prebiotics, nutraceuticals, immunostimulants, antiproliferative agents and biodegradable polymers in pharmaceutical and cosmetic sectors. A wide variety of bioresources including bacteria, fungi, lichens, algae, plants and animals produce α-D-glucans either as an exopolysaccharide (EPS) or a cell wall component or an energy storage polymer. The α-D-glucans exhibit great structural and functional diversity as the type of linkage and percentage of branching dictate the functional properties of glucans. Among the different linkages, bioactivities are greatly confined to the α-D-(1 → 3) linkages whereas starch and other polymers consisting of α-D-(1 → 4) (1 → 6) linkages are specific for food and pharmaceutical applications. However, the bioactivities of the α-D-(1 → 3) glucans in native form is limited mainly due to their hydrophobic nature. Hence several derivatization techniques have been developed to improve the bioavailability as well as bioactive features such as antiviral, antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antitumor properties. Though, several reports have presented about α-D-glucans, still there is an ambiguity in terms of their structure among different natural sources and moreover no comprehensive information was available on their derivatization techniques and application potential. Therefore, the present review summarizes distinct description on diverse sources, type of linkages, derivatization techniques as well as the application potential of the native and modified α-D-glucans.Mills' syndrome is an extremely rare, slowly progressive, unilateral ascending or descending clinical syndrome of upper motor neuron-predominant hemiparesis. In this article, we describe a case of a middle-aged woman (initial presentation and three years follow-up) who presented with progressive ascending hemiparesis with clinically isolated upper motor neuron signs and normal sensory examination. The patient received monthly intravenous immunoglobulin (IVIG) for three years with no progression of her weakness. To our best knowledge, the response of Mills' syndrome to such an IVIG program has not been reported in the literature so far. We aim to document the clinical response to IVIG in such rare syndrome.We report the case of a 14-year-old girl who was diagnosed with N-methyl-d-aspartate (NMDA)-receptor encephalitis, with severe features and autonomic instability, requiring intensive care unit admission. She had poor clinical response to the first-line therapies, she was then started on Rituximab and 6 cycles of Cytoxan infusion. She responded to Bortezomib therapy within 2 weeks of initiation, and with long-term sustenance of improvement in the long-term, also demonstrated by an improvement in NMDA titers . As far as we know, this is the first report of use of Bortezomib therapy in a child with refractory NMDA-receptor encephalitis.
This study evaluated the differences in the appearance of COVID-19 pneumonia on chest computed tomography (CT) images of outpatient and cases that developed during hospitalisation.

Chest CT images of 66 patients (median age, 76years; range, 29-94years) who underwent the severe acute respiratory syndrome coronavirus-2 reverse-transcription polymerase chain reaction (RT-PCR) test were included in this retrospective study. The chest CT appearance was categorised as "typical," "indeterminate," "atypical," or "negative" in accordance with the recommendations of the Radiological Society of North America for COVID-19 pneumonia and compared among the following four subgroups PCR-positive outpatient (n=14); PCR-positive hospitalised (n=7); PCR-negative outpatient (n=9); and PCR-negative hospitalised (n=36).

The frequency of "typical" findings in the PCR-positive outpatient cases (13/14, 92.9%) was significantly higher than that of those in the PCR-positive hospitalised cases (2/7, 28.6%, P=0.022). There was no sd time course of the infection, are required for the management of such cases.Recent reports have suggested COVID-19 relapse or reinfection may lead to readmission, which may cause a diagnostic challenge between recently infected patients and reinfections. Compounding this problem is the post-viral lung sequela that may be expected after COVID-19 pneumonia, similar to both SARS and MERS. Although chest imaging may play a role in the diagnosis of primary SARS-CoV-2 infection, reinfection or relapse of COVID-19 will have similar imaging findings. A "new-baseline" imaging can be obtained from COVID-19 patients at the time of hospital discharge or clinical recovery. This new reference can not only determine if readmissions are from relapse or reinfection of COVID-19, resolving COVID-19 or potentially a different viral infection (influenza), but also for long term sequela of COVID-19 lung infection. Strategic use of imaging before discharge may be helpful in the subset of the population at the highest risk of a secondary viral infection such as influenza. Determining the residual abnormalities in post-discharge imaging can guide us in the long-term management of patients for many years to come.
Being victimized by peers has been shown to be associated with a range of adolescent problems, including mobile phone addiction (MPA). Although being victimized is assumed to lead to problem behavior, the reverse could also occur. In this longitudinal study we tested the reciprocal effects of victimization and MPA, taking into account the role of adolescent depression in these effects.

The sample included 1987 adolescents from middle schools in Guangdong and Shandong Provinces, China (56.10% male; M
at Wave 1=12.32). Three waves of questionnaire data were collected at half-year intervals during the transition from 7th to 8th grade. Cross-lagged models were adopted for data analysis.

Peer victimization at W1/W2 predicted MPA at W2/W3, and the inverse relation was also significant MPA at W1/W2 positively predicted peer victimization at W2/W3. Furthermore, the bidirectional association between peer victimization and MPA was mediated by adolescent depression.

This is the first longitudinal study on the relation between MPA and associated problems. Victimization by peers and MPA appear to have mutual influences over time that are explained in part by adolescent depression. The results have potential applied value for promoting adolescent adjustment.
This is the first longitudinal study on the relation between MPA and associated problems. Victimization by peers and MPA appear to have mutual influences over time that are explained in part by adolescent depression. The results have potential applied value for promoting adolescent adjustment.Biocover systems are a cost-effective technology utilised to mitigate methane (CH4) and trace gas emissions from landfills. A full-scale biofilter system was constructed at Glatved landfill, Denmark, consisting of three biofilters with a total area of 3950 m2. Landfill gas collected mainly from shredder waste cells was mixed with ambient air and fed actively into the biofilter, resulting in an average load of 60-75 g m-2 d-1 for CH4 and 0.15-0.21 g m-2 d-1 for trace gases (e.g., aromatics, chlorofluorocarbons (CFCs), aliphatic hydrocarbons). The initial CH4 surface screening showed uneven gas distribution into the system, and elevated surface concentrations were observed close to the gas inlet. Both positive and negative CH4 fluxes, ranging from -0.36 to 4.25 g m-2 d-1, were measured across the surface of the biofilter. Total trace gas emissions were between -0.005 and 0.042 g m-2 d-1, and the emission flux of individual compounds were generally small (10-8 to 10-3 g m-2 d-1). Vertical gas concentration profiles showed that the oxidation of CH4 and easily degradable trace compounds such as aromatics and aliphatic hydrocarbons happened in the aerobic zones, while CFCs were degraded in the anaerobic zone inside the compost layer. In addition, oxidation/degradation of CH4 and trace gases also occurred in the gas distribution layer, which contributed significantly to the overall mitigation efficiency of the biofilter system. Overall, the biofilter system showed mitigation efficiencies of nearly 100% for both CH4 and trace gases, and it might have the potential to work under higher loads.
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