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1%). Anti-cancer drugs were involved in 73.0% pDDIs with doxorubicin as the most commonly involved (40.0%) anti-cancer followed by cyclophosphamide (27.6%) and cisplatin (13.5%). Potential cardiac adverse events made the bulk (33.8%) of predicted events. Receiving >2 anti-cancer (OR = 5.19, p-value = 0.001) and >6 ancillary drugs (OR = 4.16, p-value = 0.033) emerged as the risk factors of pDDIs.
The prevalence of pDDIs was within the range reported in published literature. Solid medication review, availability of DDI detecting tools and clinical pharmacist, and paying special attention to the high-risk patients may reduce the frequency of pDDIs at the study site.
The prevalence of pDDIs was within the range reported in published literature. Solid medication review, availability of DDI detecting tools and clinical pharmacist, and paying special attention to the high-risk patients may reduce the frequency of pDDIs at the study site.
Our aim was to clarify the impact of the nature of the capillary wall, defined by the contribution of large (LP), small (SP), and ultrasmall (UP) pores, on plasma refilling in a hemodialysis session.
This study included data from 78 patients. The relative blood volume change (ΔBV%) was monitored using a Crit-Line monitor. A bioimpedance device was used to measure extracellular and intracellular fluid volumes, and the excess fluid mass (M
) was calculated. We simulated blood volume change (sΔBV%) based on a three-pore model. Hydraulic permeability of the capillary wall (LpS) and fractional contribution of LP to LpS (α
) were determined by fitting sΔBV to ΔBV. The total refilling volume (TV
) was calculated from the total ultrafiltration volume and total blood volume change. Values were standardized to a body surface area of 1.73 m
and are denoted by the subscript BSA.
LpS and α
were 3.09 (2.32, 4.68) mL/mmHg/min and 0.069 (0.023, 0.109), respectively. The standardized regression coefficient (β) of the ultrafiltration rate (UFR
) and initial excess fluid mass (M
,
) by multiple linear regression analysis of TV
without (Model 1) and with (Model 2) α
were as follows UFR
, 0.714/<0.001 (β/p); M
,
, 0.247/<0.001 (Model 1); UFR
, 0.799/<0.001; M
,
, 0.066/0.237; and α
, -0.327/<0.001 (Model 2).
The impact of volume overload (M
,
) on plasma refilling became insignificant with the addition of α
in the model, suggesting that the nature of the capillary wall described by inter-endothelial gaps (LP) may have a greater impact on plasma refilling than volume overload.
The impact of volume overload (MExF,BSA,0) on plasma refilling became insignificant with the addition of αLP in the model, suggesting that the nature of the capillary wall described by inter-endothelial gaps (LP) may have a greater impact on plasma refilling than volume overload.
Human trafficking is an enormous global threat. Primary care clinicians are part of a safety net of professionals who may be able to identify and assist trafficking in persons (TIPs). The purpose of this systematic review was to explore clinicians' knowledge, attitudes, and behaviors in identifying and assisting TIPS in health care settings.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guided this review. Searches were conducted using PubMed, Medline Plus, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases that yielded 130 articles, of which 10 quantitative articles met eligibility criteria. Eligibility determination, data extraction, synthesis, and evaluation were independently conducted by the authors.
Findings revealed deficits in clinician's knowledge, attitudes, and behaviors on identifying TIPs in clinical settings. In addition, cultural influences affect TIP's decision-making.
To support the wide-ranging needs of TIPs, education programs that include clinician trainings on the skills required to identify and assist TIPs across cultures is warranted.
To support the wide-ranging needs of TIPs, education programs that include clinician trainings on the skills required to identify and assist TIPs across cultures is warranted.Police are considered "gatekeepers" of the criminal-legal system because their decisions significantly impact case outcomes. Using rape culture as our theoretical framework, we examine rape culture-specific factors that influence police arrest decisions in sexual assault cases reported to Los Angeles police. Importantly, extant research using this approach has overwhelmingly focused on indicators of "genuine victims," and few studies have assessed rape culture-specific indicators of suspect culpability in sexual assault case processing. The present study addresses this gap. Findings indicate that arrest decisions are motivated by rape culture-specific indicators of suspect culpability and "real rape." Theoretical and practical implications are discussed.Advances in smartphone technology have revolutionized health care providing innovative approaches to improve health and well-being. Emerging mobile health (mHealth) apps are becoming increasingly available and offer opportunities to support self-management needs in people with stroke; however, experiences with mHealth among this population are not well understood. The objective of this study is to conduct a cross-sectional survey on smartphone and mHealth app use for adults with stroke. A pilot survey of 50 adults with stroke was conducted. In all, 51% of respondents reported using their smartphone more frequently than before their stroke, and 91% reported having some degree of difficulty with its use. Respondents reported on specific challenges with app use and discussed desired content and features. Occupational therapists should familiarize themselves with valid, accessible, usable, and acceptable apps for people with stroke and consider implementing mHealth apps in self-management intervention plans to improve health, rehabilitation, and community integration outcomes in this population.Silicon dioxide nanoparticles (SiO2-NPs) are among the most widely used nanoparticles because of their chemical-physical properties. Since most brain maturation occurs in the neonatal period in humans and many mammals, it is important to understand how NPs may affect this process. see more This study tested the hypothesis that SiO2-NPs from treated dams could affect the hippocampus of neonatal rats during lactation. Twenty-four pregnant rats, after delivery, were divided into three groups of control, SiO2-NPs (25 mg/kg) and SiO2-NPs (100 mg/kg). The rats were treated from 2nd to 21st days post-delivery by gavage and the effects of these NPs were evaluated in the offspring's hippocampi to reveal the effects of maternal exposure to SiO2-NPs during lactation on the offspring's hippocampi. The offspring in the SiO2-NPs groups had higher malondialdehyde concentration and lower antioxidant activity in the hippocampi than the non-treated control group. The mean number of doublecortin positive (DCX+) cells and synaptophysin expression in the hippocampi of the SiO2-NPs groups were significantly lower than the control group, whereas the mean number of dark neurons was significantly higher. Also, animals in the SiO2-NPs groups had a weak cognitive performance in adulthood. In conclusion, maternal exposure to SiO2-NPs via breastfeeding could affect offspring's hippocampal neurogenesis and synaptogenesis, leading to impaired cognitive performance.Most faculty and staff at postsecondary institutions are mandatory reporters who must disclose sexual assault to a Title IX Coordinator. However, scholarship examining their role is sparse. We address this gap by investigating perceptions and experiences of employees (n = 166) at two institutions. Findings indicate that most employees are aware of their reporting duties, likely to comply, have received training, and support mandated reporting. Additionally, we find significant sociodemographic differences in perceptions of mandatory reporting. Those who have had a direct experience reporting have mixed reactions to the process. We discuss research and policy implications.To improve the performance of the PID controller for a steel strip deviation control system (SSDCS), an enhanced artificial bee colony algorithm (EABC) is proposed to optimize PID controller gains (EABC-PID). The proposed EABC changes the candidate solution equation to balance its explorative and exploitative capabilities. The experiment presents a detailed comparison of EABC-PID and four bio-inspired algorithms based PID controllers considering four types of objective functions. Simulation results show that EABC-PID proves to be superior for SSDCS compared to four bio-inspired algorithms based PID controller in terms of convergence, dynamic adjustment, and robustness.During public health pandemics such as COVID-19, cooperative behaviors among scientists, journal editors, policy makers and research ethics committees, are essential to promote scientific integrity and societal trust in translational research and resultant public health decisions. This cooperation is possible by expanding the current way of working to include stakeholders beyond the research team via community events and special communication channels sponsored by research ethics committees. Research ethics committees with wider communication channels, increased transparency, and enhanced knowledge exchange have the potential to improve research design, performance, dissemination, and ultimately public benefit.Although occupational therapy (OT) practitioners are well suited to address spirituality within client care, evidence suggests many practitioners feel discomfort or lack of knowledge of this subject. Few studies have delved into OTs' experiences and encapsulated if and how spirituality has been experienced in practice. This study aimed to gain a deeper and more updated insight into this phenomenon. Utilizing a phenomenological approach with interviews, this study explored OT practitioners' (n = 15) experiences with spirituality in client care. (a) Losing spirit the inadequacy of only addressing mind and body, (b) spirituality as a vehicle for reaffirming purpose in both client and therapist, and (c) addressing spirituality through functional and measurable treatments. Although the concept of mind, body, and spirit is not new, occupational therapists often do not consistently address these components simultaneously, leading to missed opportunities in client practice.
In 2020, 18.4% of Hispanics experienced mental illness, yet only about a third received treatment compared with nearly half of non-Hispanic Whites. In Montana, where only 11% of the mental health needs are currently met, service utilization is low. The purpose of this study was to determine the perceptions of the Hispanic immigrant population in a rural state on mental health and professional service utilization.
Using a descriptive phenomenological approach, we conducted semi-structured telephone interviews in Spanish. Audio recordings were transcribed, translated to English, and analyzed for themes.
We recruited a sample of 14 participants from Mexico, Ecuador, Colombia, and Venezuela ranging in age from 33 to 59. We identified five themes definitions of mental health, maintaining mental health,
socialization, stigma, and acculturation stress.
Novel findings point to the need for Spanish-language services focused on reducing stigma around mental illness and incorporating the importance of social connections.
Read More: https://www.selleckchem.com/products/NPI-2358.html
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