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Delaware novo transcriptome construction, polymorphic SSR marker pens improvement and also human population genetics analyses pertaining to the southern area of ingrown toenail corrosion (Puccinia polysora).
ObjectiveTo investigate the therapeutic effect of hyperbaric oxygen on sudden sensorineural hearing loss（SSNHL）. MethodOne hundred and seven patients with SSNHL were selected, and were randomly divided into 3 groups according to admission order. Therapeutic schedule in group A （38 cases） consisted of hyperbaric oxygen treatment once a day for 10 consecutive days, then 1 day off treatment, and on treatment for another 10 consecutive days （20 treatments in total）. Twenty-seven patients in group B were treated with hyperbaric oxygen twice per day for a total of 10 days. Forty-two patients in group C didn't receive hyperbaric oxygen therapy. Meanwhile, all patients were given conventional treatment for 14 days in accordance with the recommendations of the otolaryngology, head and neck branch of the Chinese medical association for the diagnosis and treatment of sudden sensorineural hearing loss. Patients in group A underwent pure tone audiometry after the end of treatment, and patients in group B and C were reexamined 20 days after the start of treatment, and the treatment efficacy of the three groups was compared. ResultThe overall effective rate of group A was 78.9%, and the improvement of hearing threshold was（27.2±17.5） dB HL. In group B, the overall effective rate was 81.5%, and the improvement of threshold value was（26.9±16.7） dB HL. The overall effective rate of group C was 61.9%, and the improvement of threshold value o was（17.6±18.5） dB HL. The effective rate of group C was significantly higher than that of group A or B, while there was no significant difference in efficacy between group A and group B. ConclusionThe efficacy of hyperbaric oxygen combined with drug therapy for SSNHL is better than that of drug therapy alone. find more Programs of different hyperbaric oxygen combined with drug therapy can be selected on an individual basis.ObjectiveThe aim of this study is to explore the clinical characteristics, surgical management and treatment results of type Ⅰto type Ⅳ external auditory canal cholesteatoma（EACC）. MethodOne hundred and forty-nine patients（150 ears） with EACC underwent different surgical approach according to the classification of EACC and the lesion range ① 44 ears external auditory canal lesion resection with or without reconstruction of external auditory canal ② 23 ears external auditory canal lesion resection with reconstruction of external auditory canal and the tympanoplasty（TypesⅠto Ⅲ）; ③ 32 ears external auditory canal lesion resection with reconstruction of external auditory canal and modified mastoidectomy and reconstruction of the posterior wall of external auditory canal; ④ 28 ears external auditory canal lesion resection with reconstruction of external auditory canal and tympanoplasty（Types Ⅰ to Ⅲ） and modified mastoidectomy and reconstruction of the posterior wall of external auditory canal; ⑤12 ears canal wall down mastoidectomy （CWD） with plasty of the cavity of auricular concha; ⑥ 11 ears epitympanum dectomy and reconstruction with tympanoplasty. ResultIn the 150 ears, there were 38 ears classified as Type Ⅰ, 52 as Type Ⅱ, 58 as Type Ⅲ and 2 as Type Ⅳ based on the Shin classification. All patients were followed up for more than half a year. The postoperative outcomes were satisfactory with low rate of cholesteatoma recurrence and the hearing was improved to varying degrees. ConclusionBase on the variety of lesions, the surgical treatment method of choice depends on the extent of the lesion. Effective postoperative follow-up can reduce recurrence and avoid the second operation.ObjectiveTo translate the English version of vestibular rehabilitation benefit questionnaire （VRBQ） into Chinese, and to test its reliability and validity. MethodThe VRBQ was forward and backward-translated according to the Brislin model. Cultural adaption was done by expert discussion and pilot study. The scale was applied to 158 patients to test its reliability and validity. ResultThe Cronbach's α coefficient was 0.90, and the test-retest reliability was 0.98, the total scale responsiveness is 2.066. Chinese version of VRBQ consisted of 22 items. Four factors were extracted by factor analysis, which could explain 73.341% of the total variance. ConclusionThe Chinese version of VRBQ is reliable and valid, therefore can be used to evaluate the quality of life and rehabilitation efficacy of patients with vestibular dysfunction in Chinese cultural background.ObjectiveTo investigate the feasibility of semi-free transverse cervical artery flaps for repairing the defect of head and neck tumors after operation. MethodClinical records of 15 patients were retrospectively reviewed. Ten cases were diagnosed as oral cancer, 4 cases as hypopharyngeal carcinoma and 1 case as orbito-facial mucinous adenocarcinoma. The defects of tongue, floor of mouth, gingiva or orbitomaxillofacial region after tumor resection were repaired by semi-free transverse cervical artery flap with transverse cervical artery anastomosed to facial artery or superior thyroid artery and with external jugular vein reflux. All patients received postoperative adjunvant chemoradiotherapy except for the patient with mucinous adenocarcinoma. The patients were followed up for 1-3 years. ResultAll the flaps survived after surgery. Except for one case of tongue base carcinoma recurrence, there was no definite recurrence or metastasis in the other 14 cases during the follow-up time. ConclusionSemi-free transverse cervical artery flaps show favorable healing outcome. The surgical technique is relatively simple, time-saving and cost-effective, therefore are promising in repairing the defect after operation of head and neck tumors.ObjectiveTo investigate the efficacy, complications and recurrence rate of thyroglossal duct cyst resection with hyoid preservation in children. MethodFifty-four children with thyroglossal duct cyst underwent cervical color Doppler ultrasound, CT and/or MRI before operation to make a definite diagnosis.Hyoid-preserving thyroglossal cyst resection was performed in all children.In 51 cases, the cyst wall was close to the hyoid bone, and the thin layer of the hyoid bone surface was removed, while the other 3 cases had no definite association with hyoid bone, only cysts and branches were resected.In the cases where the cyst was close to the hyoid bone, fistula tissue was found in the suprahyoid muscle group in 4 cases, which were carefully separated and excised. ResultAll patients had no complications after operation, and the incision healed in the first stage. Postoperative pathology 51 cases were thyroglossal duct cysts and 3 cases were epidermoid cysts.Follow-up for 1 years to 3 years showed that only 1 case had recurrence（2.0%,1/51）. ConclusionPostoperative recurrence of thyroid hyoid cysts does not depend on whether the hyoid bone is removed, but on the residue of its branches.The significance of hyoid bone preservation is to narrow the scope of operation, reduce trauma and complications, and avoid the impact of hyoid bone loss on vocal and swallowing function.ObjectiveTo observe the efficacy of OM85-BV in the treatment of recurrent upper respiratory tract infection with adenoid hypertrophy and to explore its possible mechanism. MethodFour hundred and forty-eight children with recurrent upper respiratory tract infection and adenoid hypertrophy were collected. Three hundred and twenty-six patients in the control group were treated with conventional drugs, and one hundred and twenty-two patients in the observation group were treated with OM85-BV+conventional drugs, and the treatment lasted 12 weeks. The sleep obstructive symptoms of adenoid hypertrophy were scored according to OSA-18 before and after the treatment respectively（0, 6, 12 weeks）. The symptoms scores and effective rate of treatment between the study and the control group were compared. The patients in the control group and the observation group who were unresponsive to drug treatment received surgery after 12 weeks of drug treatment. The levels of serum IL-2, IL-4, IL-6, IL-10, TNF, IFN-γ and IgE, the ram CD3, CD4, CD8 and CD4/CD8 between the observation group and the control group. In the observation group, the adenoid HBD-2 was significantly higher but IL-4, IFN-γ were significantly lower than that in the control group, and IL-6 had no significant difference compared with the control group. ConclusionOM85-BV can significantly improve the sleep apnea symptoms but can not rise the level of immune lymphocytes in children with adenoid hypertrophy and recurrent upper respiratory tract infection.OM85-BV can improve the Th1 immune response, enhancing the ability of human body to fight against pathogens and induce the release of HBD-2, increasing the resistance to microorganisms, reducing the bacteria aggregation, weakening the local inflammatory response in adenoids.ObjectiveThis study aimed to evaluate the sleep disorders of infants with Pierre Robin sequence by PSG, and to understand the sleep breathing characteristics of them. MethodSeventeen patients with Pierre Robin sequence underwent polysomnography lasting over 7 hours. Sleep apnea and oxygen index was recorded and analyzed. Result14（82.35%） patients with Pierre Robin sequence presented with apnea, hypopnea and hypoxemia with varying degree. The apnea-hypopnea index（12.39±9.86） and lowest arterial oxygen saturation（84.12±8.12） %were not significantly different between sexes. However, age showed a negative impact with apnea-hypopnea index, which was worse in younger infants. ConclusionMost patients with the Pierre Robin sequence have sleep apnea and hypoxemia, and appropriate management should be implemented in an early age. Polysomnography can provide objective analysis of the treatment.ObjectiveTo explore the role of rigid bronchoscope combined with high frequency ventilation in the diagnosis and treatment of infantile acute fibrinous laryngotracheobronchitis. MethodThe clinical data of 7 children with acute fibrinous laryngotracheobronchitis were analyzed retrospectively. Laryngology and bronchoscopy were conducted by hard tube bronchoscopy combined with high frequency ventilation in all cases. During the operation, a large quantity of membranous scabs was removed from subglottic area, trachea and bronchus. ResultSix cases were treated by emergency operation and cured. One patient was treated with mechanical ventilation for 48 hours because of respiratory failure. Then the operation was performed to remove the endogenous foreign body since no improvement was observed after prolonged ventilation. This patient died of multiple organ failure. The histopathological examination of these 7 cases of endogenous foreign bodies showed fibrinous exudation and necrosis, accompanied by a large quantity of inflammatory cells infiltration. ConclusionRemoval of the plastic endogenous foreign bodies which block the respiratory tract by rigid bronchoscope and high frequency ventilation under general anesthesia facilitates the diagnosis and treatment of acute fibrinous laryngotracheobronchitis in pediatric patients. Prompt surgical intervention could relieve the obstruction of respiratory tract, which is crucial to reduce mortality.
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