Notes

LncRNA-PVT1 signifies an unhealthy diagnosis and also encourages angiogenesis by means of causing the particular HNF1B/EMT axis in glioma.
The features and prognosis of adenosquamous carcinoma (ASC) in oral and maxillofacial region have not thoroughly investigated, the purpose of this study is to describe clinicopathologic characteristics, treatment, and prognostic factors of this disease.

The data of 276 patients diagnosed with ASC in oral and maxillofacial region between 1975 and 2016 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic factors influencing overall survival (OS) and disease-specific survival (DSS) were identified by the Kaplan-Meier analysis and Cox regression analysis. The nomograms for OS and DSS were constructed to predict the prognosis of these patients.

Of 276 included patients, 62.7% were male and 37.3% were female, with an average age at diagnosis of 63.5 years. The most common primary site is oral cavity (170/276), followed by salivary gland (106/276). The 3-, and 5-year OS of patients with ASC in oral and maxillofacial region were 49.0% and 38.9%, while the 3-, and 5-year DSS were 67.7%, and 60.4%, respectively. Patients who underwent surgery had longer OS (mOS 58 m vs. 8 m) and DSS (mDSS 193 m vs. 18 m) than those who did not. Age, AJCC-T/N/M category as well as surgery were independently associated with OS. Advanced T stage, distant metastases, and surgery were independent factors for DSS. The prognostic nomograms for OS and DSS were constructed, and the C-indexes were 0.71 (95% CI 0.66-0.76) and 0.76 (95% CI 0.67-0.85), respectively.

Surgery was the favorable prognostic factor for both OS and DSS among patients with ASC in oral and maxillofacial region.
Surgery was the favorable prognostic factor for both OS and DSS among patients with ASC in oral and maxillofacial region.
This study investigated and analyzed the pain degree after dental implantation and its influencing factors, and provided a scientific basis for reducing post-surgical pain in patients.

A total of 137 patients who underwent dental implantation between June 2018 to December 2019 were selected as the research subjects. Their pain intensity immediately after surgery, 24 h after surgery, and 72 h after surgery were evaluated respectively by a numerical rating scale (NRS), and the factors that affected the postoperative pain were analyzed by univariate and multivariate logistic regression analysis.

The pain intensity of patients at 24 h after dental implantation was more serious than immediately after operation and 72 h after operation (
). The results of univariate and multivariate logistic regression analysis showed that the duration of surgery and whether analgesic drug was taken postoperatively were used in the regression model (
), which are independent risk factors for the occurrence of pain 24 h after surgery.

The pain degree of most patients after oral implantation is mild, and the most obvious pain reaction is 24 h after operation. The use of postoperative analgesics can effectively relieve the pain of patients, and the long duration of surgery is one of the key factors leading to postoperative pain.
The pain degree of most patients after oral implantation is mild, and the most obvious pain reaction is 24 h after operation. The use of postoperative analgesics can effectively relieve the pain of patients, and the long duration of surgery is one of the key factors leading to postoperative pain.
To investigate the effect of dexmedetomidine combined with epidural anesthesia on cognitive dysfunction (POCD) in elderly patients after orthopedic surgery.

A total of 187 elderly patients who needed orthopedic surgery in our hospital from January 2019 to December 2020 were randomly divided into an experimental group (n=95) and a control group (n=92). The patients in the experimental group were administered 1 μg/kg dexmedetomidine hydrochloride injections, and the patients in the control group were administered 0.9% sodium chloride injections, which were infused using a micropump for about 10 minutes. The two groups' cognitive function, VAS scores, and vital signs were compared.

There were significant differences in the two groups' mean arterial pressures and heart rates at intubation time (T3), operation start time (T4), and extubation time (T6) (P < 0.05). The VAS scores in the experimental group were significantly different from the VAS scores in the control group at 24 hours after the operations, 48 hours after the operations, 72 hours after the operations, and 7 days after the operations (P < 0.05). There were no significant differences in the anesthesia times, the average bleeding volumes, or the average operative durations (P > 0.05). Selleckchem Androgen Receptor Antagonist 48 hours after the operations, the MMSE score in the experimental group was (27.15±1.17), which was significantly different than the MMSE score in the control group (23.11±0.83), and the difference was statistically significant (P < 0.05).

Epidural anesthesia combined with dexmedetomidine has little circulatory interference in elderly patients; moreover, it can reduce the incidence of postoperative cognitive dysfunction in elderly patients.
Epidural anesthesia combined with dexmedetomidine has little circulatory interference in elderly patients; moreover, it can reduce the incidence of postoperative cognitive dysfunction in elderly patients.
To explore the effects of empathy nursing on the quality of life and treatment compliance of elderly patients with cerebral infarction (CI).

Elderly patients (n=136) with CI hospitalized in our care were enrolled in this prospective study. The patients were randomly divided into an observation group and a control group by a random number table, with 68 patients in each group. Patients in the control group were given routine nursing, while patients in the observation group were given empathy nursing. The anxiety, depression, quality of life, treatment compliance, sleep quality and nursing satisfaction of the core family members of the two groups were compared.

The observation group had lower Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores, with significantly higher scores of physical function, general health, social function, emotional role, and mental health than the control group (all P<0.001). The treatment compliance rate (P<0.01) and nursing satisfaction of the core family members (P<0.05) of the observation group were significantly higher, and the Pittsburgh Sleep Quality Index scores were lower (P<0.001) than those of the control group.

The application of empathy nursing in elderly patients with CI relieves depression and anxiety, improves quality of life, treatment compliance, sleep quality of patients, and improves nursing satisfaction of the core family members. As such, it is worth clinical promotion and application.
The application of empathy nursing in elderly patients with CI relieves depression and anxiety, improves quality of life, treatment compliance, sleep quality of patients, and improves nursing satisfaction of the core family members. As such, it is worth clinical promotion and application.
To assess the clinical effect and safety of double anti-platelet therapy combined with different doses of statins for acute cerebral infarction complicated with microhemorrhage.

A total of 312 patients who had acute cerebral infarction complicated with microhemorrhage in our hospital were randomly allocated into two groups the experimental group (n=164) and group for control (n=148). Those in the group for experiment received dual antiplatelet rosuvastatin tablets (20 mg QN), while the control group received dual antiplatelet rosuvastatin tablets (10 mg QN). After 30 days of treatment, blood biochemistry and brain magnetic resonance imaging were performed to record the serum lipid levels, liver transaminase, inflammatory and oxidative stress indicators and other biochemical indicators as well as the number of cerebral microhemorrhage foci.

Serum lipids in both groups after intervention were decreased compared to those without intervention (P < 0.05). Furthermore, after receiving the intervention, the HCY and inflammatory indicators (such as hs-CRP) of the two groups were improved compared to before intervention (P < 0.05). The safety index (Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Creatine kinase (CK), creatinine (Cr)) had no statistically significant difference than those without intervention in the two groups (P > 0.05).

Rosuvastatin can effectively regulate blood lipids and Hcy levels in patients with acute cerebral infarction and microbleeds, and it can reduce blood lipids and inflammation; furthermore, high dose rosuvastatin has better improvement effects and higher safety in a shorter period time.
Rosuvastatin can effectively regulate blood lipids and Hcy levels in patients with acute cerebral infarction and microbleeds, and it can reduce blood lipids and inflammation; furthermore, high dose rosuvastatin has better improvement effects and higher safety in a shorter period time.
To investigate the application of traditional Chinese medicine (TCM) syndrome differentiation in identification of body constitution of hypertensive and diabetic patients.

A total of 110 hypertensive patients with diabetes treated in our hospital were enrolled in this study, and were divided into a study group (SG, n=60) and a control group (CG, n=50) according to different intervention methods. Patients in the CG received conventional western medical intervention for hypertension and diabetes, while patients in the SG received body constitution-identified TCM syndrome differentiation intervention additionally. The changes of blood pressure and plasma glucose during the intervention were compared between the two groups, the clinical effect and quality of life of the two groups were evaluated, and multivariate stepwise Logistic regression analysis on influencing factor of TCM body constitution was conducted.

Compared with that before intervention, the proportion of gentleness constitution in the SG showes constitution are the risk factors for hypertension with diabetes.
Body constitution-identified TCM syndrome differentiation treatment for hypertensive patients with diabetes is effective, which can significantly improve the plasma glucose and blood pressure indices of patients. Dampness-heat constitution, blood-stasis constitution, Yin-deficiency constitution and phlegm-dampness constitution are the risk factors for hypertension with diabetes.
This study was designed to investigate the sensitivity and specificity of the three-dimensional (3D) pelvic floor ultrasound and the conventional ultrasound in pelvic floor assessment after delivery.

A total of 108 patients with pelvic floor dysfunction treated in our hospital were selected as the study group, and another 108 healthy subjects were included as the control group. Both groups were diagnosed by conventional ultrasound and 3D pelvic floor ultrasound, and confirmed with pathological findings. The diagnostic results of the conventional ultrasound and 3D pelvic floor ultrasound were compared, and the diagnostic conditions of various indicators in the two groups were compared.

The numbers of true positive cases and true negative cases diagnosed by the conventional ultrasound were 84 and 90, respectively, while the numbers of true positive cases and true negative cases diagnosed by the 3D pelvic floor ultrasound were 8 and 102, respectively (
<0.05). The accuracy, specificity, and sensitivity of the conventional ultrasound were 80.
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